SUBJ: I have added a lot of new material
SUBtitle: I have written a pamphlet, “SAFE AND PROVEN, Steps to a Healthy Lifespan,”
Useful links for new readers: how to get newsletter, links to nutritionconsensus.org/products; whyweage; 46steps to slow aging; Key word search command
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SHORT NOTES: My website was hacked Oct 19, but I recovered access, and I have added a lot of new material.
I have written a pamphlet about 15 pages long, “SAFE AND PROVEN, Steps to a Healthy Lifespan,” next week free paid subscribers or purchased by sending $5 to ordman@beloit.edu through PayPal.
In a trial of 7,500 people who had a coronary incident, those who were put on a low fat diet had a 30 to 50% greater chance of a heart attack.
Effects of 4 “Anti-Aging” Food Supplements in Healthy Older Adults). Coenzyme Q10 100 mg bid, Selenium 100 mcg, Resveratrol 350 mg bid, Astragalus Membranaceus extract 100U.
A blood test) has proven its accuracy and reliability in predicting the best treatment for metastatic non-small cell lung cancer (NSCLC)
Detecting too much calcium in the arteries requires treatment
clinical trials for treatment of ulcerative colitis and Crohn’s Disease,
AARP: foot exercises to prevent falls
US approval for vision-correcting eye drops
A shortage of 37,800 to 124,000 physicians is to be expected by 2034
From Kevin: There’s far too much ugly in the world right now. It’s everywhere. Ugly only gets worse when we don’t listen and care for one another…
We need aging clocks to test remedies in humans without waiting decades
Technology that optimizes clinical trial design and analysis.
LONG NOTES:
My website was hacked Oct 19, but only other websites were set up, and now they have been taken down. I just recovered access, and I have added a lot of new material. 3 Essays How to have a baby boy, why we age, value of melatonin; updates to many nutrients like NAD, and much more.
I have written a pamphlet about 15 pages long, “SAFE AND PROVEN, Steps to a Healthy Lifespan,” which is a summary for a dear friend about how to live a long, healthy life. Next week I will be sending it out to paid subscribers to the newsletter. It can also be purchased by sending $5 to ordman@beloit.edu through PayPal.
In a trial of 7,500 people who had a coronary incident, those who were put on a low fat diet had a 30 to 50% greater chance of a heart attack or stroke than those who were placed on a Mediterranean diet.
Can We Slow Down Biological Age Progression? Study Protocol for the proBNPage Reduction (PBAR) Randomized, Double-Blind, Placebo-Controlled Trial (Effects of 4 “Anti-Aging” Food Supplements in Healthy Older Adults). Testing Coenzyme Q10 100 mg bid, Selenium 100 mcg, Resveratrol 350 mg bid + TA-65 (Astragalus Membranaceus extract) 100U.
A trial of the PROphet blood test from Israel’s OncoHost (see here previously) has proven its accuracy and reliability in predicting the best treatment for metastatic non-small cell lung cancer (NSCLC) patients. OncoHost has received orders from 29 US cancer centers since its 2023 launch.
Detecting too much calcium in the arteries. Israel’s Beilinson Hospital has completed a study of coronary artery calcium (CAC) levels using the HealthCCSng system from Israel’s Nanox.AI (see here previously) to review routine CT-scans. High CAC patients were referred to clinics for in-depth evaluation and treatment.
Israel’s Teva is partnering with France’s Sanofi (see also here) to develop and commercialize TEV 574, currently in Phase 2b clinical trials, for the anti-TL1A treatment of ulcerative colitis and Crohn’s Disease, two types of inflammatory bowel disease (IBD).
AARP: foot exercises to prevent falls– Unintentional falls are the leading cause of injury and injury deaths among adults age 65 and older, and more than 95 percent of hip fractures. 1. Ankle circles 2. Toe pulls -try lifting only your big toe off the ground, etc. 3. Calf raises -Stand near a wall for support. 4. Straight leg calf stretch 5. Bent leg calf stretch 6. Single leg balance 7. Towel curl- Using your toes and keeping your heel on the ground, curl the towel toward you until it is bunched up. 8. Ball roll 9. Down dog walk 10. Happy baby
US approval for vision-correcting eye drops. The US FDA has approved the QLOSI eye drops, from Israel’s Orasis (see here previously), The prescription eye drops improve farsightedness (presbyopia) for up to eight hours without impacting distance or night vision. The treatment can benefit almost two billion sufferers.
In a new study released by the Association of American Medical Colleges (AAMC), a shortage of 37,800 to 124,000 physicians is to be expected by 2034. “It’s estimated that more than 83 million people in the U.S. currently live in areas without sufficient access to a primary care physician.
From Kevin: The Ugly – There’s far too much ugly in the world right now. It’s not only the ongoing wars in Israel and Gaza and in Ukraine or, the trauma we are all experiencing up here in Maine. It’s everywhere. Ugly only gets worse when we don’t listen and care for one another…
From GRG discussion: we really need aging clocks if we are ever going to be able to test remedies in humans without waiting decades to evaluate the effects of each one.
And which clock you have faith in depends on what you think aging is. If you think that aging is a loss of information, then the Conboys’ entropy clock makes a lot of sense. If you think that aging is programmed through gene expression, than Horvath’s methylation clocks make sense.
And in general, we have to prioritize different directions for anti-aging medicine. If you think that the body suffers damage because of some physical necessity then you have to go in and repair each separate kind of damage. If you think the body knows how to repair the damage but biochemical signals are instructing the body to “stand down” and not repair, then you invest in approaches that modify the signaling environment.
Israel’s PhaseV develops causal machine learning (ML) technology that optimizes clinical trial design and analysis. Its goal is to prevent bio-techs wasting money on failed or badly designed trials of new treatments. It boosts clinical trial success rates while maximizing resource and time efficiency.
The research team found that when standard care was accompanied by personalized lifestyle coaching (focused on diet, exercise, brain training, and so on), patients had better cognitive outcomes than when they received standard care alone. These outcomes are also better than those typically seen in studies of Alzheimer’s drugs.
