Brown’s study was followed by one by Meydani et al that compared 60, 200, and 800 mg daily. They demonstrated that the 200 mg dosage was superior in elevating the immune response in elderly participants, and it is especially important to note that there were no adverse effects seen in this study, as has been consistently true for vitamin E. “88 free-living, healthy subjects at least 65 years old… were randomly assigned placebo or 60, 200, or 800 mg/d of vitamin E for 235 days… Subjects consuming 200 mg/d of vitamin E had a 65% increase in [immune cells]… No adverse effects were observed with vitamin E supplementation.” Meydani, S.N., et al. “Vitamin E supplementation and in vivo immune response in health elderly subjects”, JAMA 277: 1380-86 (1997))
AREDS 2 has 180mg vitamin E
