Skip to main content

SUBJ: PLEASE EXERCISE!!!

SUBtitle: AREDSII, niacin, Mito-C, perhaps metformin

See past newsletters here . About the last 4 letters have had discoveries about how vital exercise is to healthspan. Results have inspired me to keep jogging twice a week even though my triathlon is finished.

SHORT NOTES: Irisin levels dramatically increase when we exercise – which is most likely why we see those who exercise as having significantly fewer problems with Alzheimer’s and other related dementias;  Exercise over 3 days or more, for a minimum of 10 minutes at a time, helps stop, delay, and sometimes improve serious illnesses like heart disease, high blood pressure, diabetes, stroke, Alzheimer’s disease, arthritis, and osteoporosis; you need to get vaccinated—even if you’ve already had COVID;  Last time I noted many adults are deficient in zinc-so take AREDS II which is loaded with zinc; Strengthen your immune system- sleep, low anxiety, 2 to 5K vitamin D, fruits and veggies, low fat except fish oil, walking outdoors, avoid grieving too much; exercise; sex!! More than 30% of the U.S. population has prediabetes; more than 84% of them do not know it; Poor air quality is linked to poor health; The gene-editing technique known as CRISPR achieved a new milestone in which doses were injected into a person and cured him;  Quitting smoking after a diagnosis of early-stage lung cancer may help people live longer; We need to supplement with niacin as we age: chronic, low grade inflammation contributes to the pathogenesis of age-related diseases. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation; The health services in Norway are second to none, at a fraction of the cost in the US; “The convergence of many seemingly unrelated elements has produced an explosion of brainlessness.”

LONG NOTES:

I was quite taken by a recent article in the Nature Metabolism on exercise and Alzheimer’s disease. In a nutshell, the article talks about how a hormone [that I had never heard of…] called “Irisin” could represent a protective capability for neuro-function perhaps through a decrease in neuroinflammation! In short, the hormone appears to dramatically improve memory in mice through a positive impact on the hippocampus where “memories” are managed. The long and short of the article; however, is that Irisin levels dramatically increase when we exercise – which is most likely why we see those who exercise as having significantly fewer problems with Alzheimer’s and other related dementias! So, get out there and do your thing.

AARP: How to stay strong as you age: You Need Exercise Now More Than Ever;  Exercise helps stop, delay, and sometimes improve serious illnesses like heart disease, high blood pressure, diabetes, stroke, Alzheimer’s disease, arthritis, and osteoporosis.; Cardio or aerobic exercise gets your heart rate up and makes you breathe harder, which builds your endurance and burns calories. Strength or weight training keeps your muscles ready for action. Flexibility exercises help you stay limber so you can have a full range of movement and avoid injury. Balance training becomes important after age 50, so you can prevent falls and stay active.; dancing!; golfing if you skip the car – an average round is more than 10,000 steps, or about 5 miles! Cycling, Racquet sports, Tai Chi, This quiet exercise is sometimes called “moving meditation.” How Much?If you’re in good health, you should get at least 150 minutes of moderate cardio activity a week. It’s better when you spread it out over 3 days or more, for a minimum of 10 minutes at a time

Do you need a #COVID19 vaccine if you’ve already had COVID? Dr. Vivek Murthy, the U.S. Surgeon General, explains that getting vaccinated—even if you’ve already had COVID—boosts immunity to help prevent reinfection and reduce spread. youtu.be/RjIZdqYqwWU #WeCanDoThis

Zinc in AREDS II. Last time I noted many adults are deficient in zinc, which is important for the immune system.  AREDS II is loaded with zinc so no worries if you are taking it.

AARP: Strengthen your immune system: sleep, low anxiety, 2 to 5K vitamin D, fruits and veggies, low fat except fish oil, walking outdoors, avoid grieving too much; exercise; sex

More than 30% of the U.S. population has prediabetes; more than 84% of them do not know it. Because prediabetes can lead to type 2 diabetes, heart disease and stroke, screening is key. As such, the U.S. Preventive Services Task Force (USPSTF) released new guidelines for earlier screenings for those at high risk. The USPSTF recommends screening for adults aged 35-70 who are overweight or obese. Certain groups may need to be screened even earlier. Many racial minorities have high risk. So do those with a family history of the disease.

Using data from NASA, a study looked at nitrogen dioxide pollution levels in U.S. cities shut down by the pandemic. Less car traffic reduced air pollution in most urban areas. Still, levels stayed as much as 50% greater in low-income Black and Latino neighborhoods than they were in nearby affluent areas — even prior to the pandemic. This is likely due to closer proximity to busy roads. Poor air quality is linked to poor health.

It’s a win for precision medicine! The gene-editing technique known as CRISPR achieved a new milestone. Patrick Doherty, 65, learned he has a rare inherited condition called transthyretin amyloidosis, which causes a buildup of protein in the organs and tissues. The disease killed his father and uncles. In a short time, Patrick went from climbing mountains to being unable to climb stairs. He was eager to fly from Ireland to London to get one of the first CRISPR procedures in which doses were injected directly into the blood. The process caused the protein levels to drop, and Patrick is now one of six patients whose condition improved. “I feel fantastic,” he says.

Quitting smoking after a diagnosis of early-stage lung cancer may help people live longer, a new study finds.

From AGE: Need to supplement with niacin as we age: There appears to be abidirectional interactions between host and microbes that may provide a means to maintain NAD homeostasis as we age.

During ageing, chronic, sterile, low-grade inflammation — called inflammaging — develops, which contributes to the pathogenesis of age-related diseases.

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

I am a Norwegian currently living in Florida – March 20, 2016

I would like to give you an example from the health system. My doctor’s office in Norway has 5 doctors, a nurse that runs the reception, and a nurse running the lab. As the health service is free, there are no insurance companies or billing departments.

My doctor’s office in Florida have two doctors, 5 nurses doing paperwork, plus an administration to take care of insurance claims. That is not including the lab. In addition there are people working at insurance companies handling the claims.

There must be millions of people in the US just doing unproductive paperwork caused by a dysfunctional health system. The health services in Norway are second to none, at a fraction of the cost in the US. In the US a normal health insurance cost about $1,000 per month per person. This figure would shock the rest of the world.

Try out this article from the August 29th issue of The Wall Street Journal (WSJ), titled: “You Are Living in the Golden Age of Stupidity” or, as the author – Lance Morrow – noted: “The convergence of many seemingly unrelated elements has produced an explosion of brainlessness.” Enjoy…