SEPSIS treated with vitamin C
Patents with sepsis predictably have very low serum vitamin C levels, which can only be corrected with intravenous vitamin C in a dose of more than 3gm per day. (2016 below)
(2016) Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study https://digitalcommons.odu.edu/cgi/viewcontent.cgi?article=1127&context=bioelectrics_pubs
FROM NIH: Clinical Studies of Vitamin C in Sepsis- Sepsis is associated with enormous stress to the organism [58]. In animals exposed to stress, an increased endogenous synthesis of ascorbate was found as a compensatory mechanism to maintain the homeostasis [44,59]. However, for critically ill patients, neither do we know an optimal vitamin C plasma concentration nor is it known whether supernormal plasma concentrations are more beneficial [60,61]. However, a number of studies demonstrated that parenteral administration of vitamin C is more effective to increase plasma levels and reduce multi-organ failure.
[44] Stress-induced change in tissue levels of ascorbic acid and histamine in rats. Nakano K, Suzuki S J Nutr. 1984 Sep; 114(9):1602-8. [PubMed] [Ref list]
[60] Review Evaluation of vitamin C for adjuvant sepsis therapy. Wilson JX Antioxid Redox Signal. 2013 Dec 10; 19(17):2129-40. [PubMed] [Ref list]
[61] Review Vitamin C supplementation in the critically ill patient. Berger MM, Oudemans-van Straaten HM Curr Opin Clin Nutr Metab Care. 2015 Mar; 18(2):193-201. [PubMed] [Ref list]
(2018) Vitamin C: The next step in sepsis management? Journal of Critical Care Volume 43, February 2018, Pages 230-234 “Vitamin C: The next step in sepsis management?” https://www.sciencedirect.com/science/article/abs/pii/S0883944117310596
(2015) Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock? Critical Care volume 19, Article number: 418 (2015) https://ccforum.biomedcentral.com/articles/10.1186/s13054-015-1131-2
