mTOR
The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival. mTOR inhibition extends life span in multiple organisms. In mice, when metformin treatment (Met) is added to the mTOR inhibitor rapamycin (Rap), median and maximal life span is extended to a greater degree than with Rap or Met alone [ref]. However, BCAAs (branched chain amino acids Leu, Iso, Val) are often taken in 5 g doses by athletes to restore sore muscles, and this activates mTOR and shortens lifespan. I used to take leucine after a workout, which helped heal strained muscles but was damaging to long term health.
