Arthritis Is Caused By Protein Misfolding Which is Reduced by Mito-C
Some evidence in scientific literature:
Jul 27, 2017 – According to the researchers, acidic conditions favor misfolding and harmful accumulation of various proteins in AA, Alzheimer’s disease, and many other deadly human disorders called protein misfolding diseases or amyloidoses. … “Our results suggest how this cell defense fails in AA amyloidosis.
Jan 5, 2014 – Bone Loss in Spondyloarthritis Linked to Protein’s Misfolding … with spondyloarthritis become damaged and deformed, causing back and hip pain, … It causes inflammation of the joints between the spinal bones, as well as the new hope for diseases of protein folding such as Alzheimer’s …
Jan 8, 2012 – More than 300 diseases have at their root proteins that misfold, aggregate and … (the entire set of proteins expressed by the organism) from protein damage. .
Cellular Responses to Misfolded Proteins and Protein by SA Houck – 2012 – Cited by 24 – Related articles
May 27, 2015 – The accumulation of different forms of misfolded protein can perturb protein homeostasis and cause extensive cell and tissue damage.
Nature Vol 426 No 6968 (Insight) pp883-909 18/25 December 2003
Although it has long been known that the amino-acid sequence in some way dictates the biologically active conformation of a protein, the experimental tools required to probe the intermediate states along the folding pathway have only begun to become available in the past decade or so. These tools are revealing a tightly regulated assembly line, where multiple factors guide nascent proteins to select the correct shape from an almost infinite array of possibilities.
Becoming apparent are the stringent quality-control systems that come into play if the folding process fails, ensuring that the misfolded products are targeted for degradation before they cause harm. Those that escape this cellular surveillance are prone to forming aggregates that can damage or kill cells through mechanisms that are just beginning to be understood.
A huge variety of previously unrelated diseases, such as prion diseases, diabetes and cancer, share the pathological feature of aggregated misfolded protein deposits. This suggests the exciting possibility that these ‘protein-misfolding diseases’ are linked by common principles, and may therefore present common targets for therapeutic intervention.
June 2019 – Here we summarize the possible effects of oxidative stress in the aged muscle and the benefits of physical activity and antioxidant therapy. in Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 4617801, 12 pages
