Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts. Highlights
• Adherence to MEDLIFE index was associated with lower GDF-15 levels in older adults.
• Physical activity, rest, social habits and conviviality was the main contributor.
• Combining lifestyle factors may be an integral approach to reduce inflammaging.
• Modest improvements in circulating GDF-15 may have public health relevance.
