Diosmin is a chemical in some plants. It’s found mainly in citrus fruits. Diosmin is most often used for hemorrhoids and leg sores caused by poor blood flow. It’s also used for other conditions, but there’s no strong evidence to support these uses.

From GRG Kingsley Morse- Nature Scientific Reports’ July 2021 issue says diosmin was AI’s top prediction for extending the life span of worms.

Numerous studies suggest that diosmin helps treat internal and external hemorrhoids. In a review of 24 studies in over 2,300 people, plant flavonoids like diosmin decreased hemorrhoid-related itchiness, bleeding, discharge, and other hemorrhoid symptoms (10Trusted Source).

Random forest classification for predicting lifespan-extending chemical compounds.  Ageing is a major risk factor for many conditions including cancer, cardiovascular and neurodegenerative diseases. Pharmaceutical interventions that slow down ageing and delay the onset of age-related diseases are a growing research area.   The aim of this study was to build a machine learning model based on the data of the DrugAge database to predict whether a chemical compound will extend the lifespan of Caenorhabditis elegans.  The chemical compounds of the screening database with a predictive probability of ≥ 0.80 for increasing the lifespan of Caenorhabditis elegans were broadly separated into (1) flavonoids, (2) fatty acids and conjugates, and (3) organooxygen compounds.

Here is the table of results.  While Diosmin scored 96% probability to extend lifespan, lactose scored 89% and sucrose 83%.  But they point out that lactose, with a lifespan increase probability of 0.89, is a disaccharide found in milk and other dairy product. In the human intestine, lactose is hydrolysed to glucose and galactose by the enzyme lactase. Out of the compounds in the DrugAge database, lactose had the highest structural similarity with trehalose. Trehalose has been found to increase the mean lifespan of C. elegans by over 30%, without showing any side effects59.