Tocotrienols
vitamins related to vitamin E, tocopherol

After reading about tocotrienols, I have decided to take a small amount regularly.  I will be taking 50mg of mixed tocotrienols twice a week, primarily for their benefit to nerve cells!  How much gamma-tocopherol and tocotrienols should one take? Although tocopherols are predominantly found in corn, soybean, and olive oils, tocotrienols are particularly rich in palm, rice bran, and barley oils. Tocotrienols possess powerful antioxidant, anticancer, and cholesterol-lowering properties. Recently, researchers have observed that alpha-tocotrienol is multi-fold more potent than alpha-tocopherol in protecting HT4 and primary neuronal cells against toxicity induced by glutamate as well as by a number of other toxins. At nanomolar concentration, tocotrienol, but not tocopherol, completely protected neurons by an antioxidant-independent mechanism.   sources of tocotrienols include grape fruit seed oil, oats, hazelnuts, maize, olive oil, buckthorn berry, rye, flax seed oil, poppy seed oil and sunflower oil.

GRG comments on tocotrienols

I only take vit E as part of a senior vit complex and Tocomin SupraBio tocotrienols is too much is harmful (Areds used to use too much but I believe they’ve lowered the amount).

Basic article on tocotrienols

Tocomin – Mickey – Among other things, I have experienced increased hair count and some darkening of graying/whitening hair with the use of Tocomin SupraBio tocotrienols (antioxidants), with more hair count being seen after daily consumption for about five months and some darkening of hair seen after about 18 months.

Carotech’s Tocomin SupraBio, ensures increase in absorption of each individual tocotrienols (alpha, gamma and delta-tocotrienol) by up to 300%. Hence, customers are able to lower the therapeutic dosage, resulting in lower cost and most importantly, be guaranteed of increased and consistent absorption for optimum protection.

The absolute oral bioavailability for d-alpha-, d-gamma- and d-delta-tocotrienol (from a tocotrienol oil extract) is as follow:-

d-alpha-tocotrienol – 27.7%

d-gamma-tocotrienol – 9.1%

d-delta-tocotrienol – 8.5%

As such:– For 50 mg of d-delta-tocotrienol (from Annatto tocotriennol, Delta-Gold) per capsule, the absolute oral bioavailability (blood level) is only 50mg x 8.5% or equivalent to approximately 4.25mg only .

– In comparison, for 50 mg of d-mixed tocotrienol from Tocomin SupraBio per capsule, the absolute oral bioavailability (blood level) is as below:-

d-alpha-tocotrienol – 14.6mg x 27.7% x 2.5 = 10.1 mg

d-gamma-tocotrienol – 26.6mg x 9.1% x 2.5 = 6.1 mg

d-delta-tocotrienol – 7.0mg x 8.5% x 2.5 = 1.5 mg

Total d-mixed tocotrienol ~50.0mg 17.7 mg

A 4X increase in blood plasma level compared to annatto-delta-gold tocotrienol.

We have previously shown that alpha-tocotrienol (alpha-T3), a vitamin E analogue and HMG CoA reductase (HMGR) inhibitor, markedly inhibited monocyte-endothelial cell adhesion, a process that was reversed with the addition of mevalonate intermediates involved in protein prenylation. Since delta-T3 and gamma-T3 possess greater HMGR inhibition than alpha-T3, we postulated that these analogues might have a greater effect on protein prenylation, and thus on monocyte adhesion and endothelial adhesion molecule expression in comparison to alpha-T3. Hence, we pursued to investigate the effect of various analogues of tocotrienol (alpha, gamma, delta) on monocytic cell adhesion and expression of adhesion molecules using a human umbilical vein endothelial cell-line, EA.hy926, as the model system. Relative to alpha-T3, delta-T3 displayed a more profound inhibitory effect on monocytic cell adherence using a 15 micromol/L concentration within 24 h (delta: 42 +/- 5%; alpha: 26 +/- 8% vs. control). This inhibitory action was reversed by co-incubation with farnesol and geranylgeraniol, suggesting a role for prenylated proteins in the regulation of monocyte adhesion. To further evaluate the effect of tocotrienols on the vascular endothelium, we measured the surface expression of adhesion molecules. Compared to alpha-T3, delta-T3 markedly inhibited the expression of VCAM-1 (delta: 57 +/- 6%; alpha: 37 +/- 10% vs. control) and E-selection (delta: 36 +/- 3%; alpha: 18 +/- 6% vs. control) in TNF-alpha activated endothelial cells. The above result suggests that delta-T3 is a potent and effective agent for the reduction of cellular adhesion molecule expression and monocytic cell adherence.

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Carotech’s Tocomin SupraBio, ensures increase in absorption of each individual tocotrienols (alpha, gamma and delta-tocotrienol) by up to 300%. Hence, customers are able to lower the therapeutic dosage, resulting in lower cost and most importantly, be guaranteed of increased and consistent absorption for optimum protection

As you can see – the low absolute oral bioavailability of d-delta-tocotrienol – give a negligible amount in the plasma as compare to Tocomin SuporaBio.

In additional, researchers that use Tocomin SupraBio human clinical trials found the tocotrienols level in the blood plasma to be significant.

Reversing Arteriosclerosis with Tocotrienols: An interview with Marvin Bierenbaum, M.D. and Tom Watkins, Ph.D. by Richard A. Passwater, Ph.D.

A nutritional cure for heart disease? Well, here’s exciting evidence that arteriosclerosis (the thickening, loss of elasticity and calcification of arterial walls; a common form of which is atherosclerosis) can be reversed with a mixture of tocotrienols and tocopherol). Tocotrienols and tocopherols are vitamin E vitamers, that is, they are both sub-families of the vitamin E family. Tocopherols are the more familiar forms of vitamin E, but tocotrienols may have additional functions and health benefits. In a three-year, double-blind clinical study, tocotrienols, which are derived from rice and palm oils, have been shown to regress arteriosclerosis. In the group that received tocotrienols, 92 percent of the patients stabilized or improved, whereas in the control group, 48 percent of the patients deteriorated and none improved. In vivo evidence of gamma-tocotrienol as a chemosensitizer
in the treatment of hormone-refractory prostate cancer.
http://www.ncbi.nlm….pubmed/20375535

Gamma-tocotrienol suppresses prostate cancer cell proliferation
and invasion through multiple-signalling pathways.
http://www.nature.co…l/6604763al

Gamma-tocotrienol as an effective agent in targeting
prostate cancer stem cell-like population.
http://www.ncbi.nlm….ubmed/20617516/

Gamma-tocotrienol induced apoptosis is associated with unfolded protein
response in human breast cancer cells.
http://www.ncbi.nlm….pubmed/21429729
” Study suggests that tocotrienol has a common cancer-killing mechanism for different cancer types. “
http://www.bionity.com/en/news/116005Researchers have found that two natural compounds, when combined, successfully remove aging cells from the body without harmful side effects.

Tocotrienols + Quercetin lef 2016

Tocotrienols, the less well-known members of the vitamin E family, are emerging as the ideal senolytic nutrient. Studies show that tocotrienols have dual and complementary actions:·        In cancer cells, tocotrienols can stimulate cellular senescence, shutting down their malignant potential.      In healthy tissue, tocotrienols can slow aging changes, promote normal cell division and specialization, and prevent cells from reaching their damaging final aging state.10-14

Studies have shown the benefits of combining tocotrienols with quercetin, a flavonol found in many fruits and vegetables. Quercetin also has dual and complementary actions with regards to aging cells. Like tocotrienols, quercetin can induce senescence and promote cell death in numerous types of cancer cells.6,15 And, like tocotrienols, quercetin has the opposite effect in healthy cells, delaying senescence in younger cells and rejuvenating older cells to rid them of their abnormal, age-promoting function.1,6