Chondroitin

From the following, it appears that using chondroitin and glucosamine for a month. If relief is not noticeable, they may be causing harm rather than benefit.

From NIH: What do we know about the effectiveness of glucosamine and chondroitin supplements? Research results suggest that chondroitin isn’t helpful for pain from osteoarthritis of the knee or hip.

2018 – Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. 

50% of people find that glucosamine and chondroitin supplements after a month of use provide some relief. 30 trials met our inclusion criteria. Given the effectiveness of these symptomatic slow-acting drugs, oral chondroitin is more effective than placebo on relieving pain and improving physical function. Glucosamine showed effect on stiffness outcome. Regarding on the limited number of combination therapy, further studies need to investigate the accurate effectiveness. This information accompanied with the tolerability and economic costs of included treatments would be conducive to making decisions for clinicians.

AARP Joint pain –  Twenty-six percent of poll respondents say they turn to supplements like glucosamine and chondroitin to help manage joint pain, but osteoarthritis guidelines don’t recommend them, due to scant scientific evidence. A 2016 study published in Arthritis & Rheumatology found these supplements, when given in combination, had the opposite effect.

Chondroitin/Glucosamine help for knee pain – Conducted for 16 weeks in 100 Japanese subjects (age, 51.8±0.8 years) with knee pain. Subjects were randomly assigned to one supplement containing 1) 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, and 5 µg of vitamin D per day (GCQID group, n=50). In subjects with knee pain, GCQID supplementation was effective for relieving knee pain and improving locomotor functions. BUT NOTE THE BENEFIT MAY BE FROM OTHER SUPPLEMENTS BESIDES CHONDROITIN.