SUBJ: Big news for May Day: New York Times tells how to live to 200
SUBtitle: Melatonin stops sarcopenia
SHORT NOTES: Roadmap to live to 200 in the New York Times ; Melatonin plays a role in the prevention and treatment of sarcopenia; GRG suggestions to reduce arthritis pain; Caffeine has tremendous health benefits; GRG advice to control weight-daily weighing; Wearing a mask cuts asthma and allergies; Pros and cons of topical rapamycin to rejuvenate your skin.
LONG NOTES
Roadmap to live to 200 in the New York Times
The role of melatonin in sarcopenia: Advances and application prospects; Melatonin plays a role in the prevention and treatment of sarcopenia through various mechanisms. It is currently known that it can protect the mitochondria of skeletal muscle cells, maintain the number of muscle fibres, partially reverse the pathological changes of ageing muscle tissue, and increase muscle strength in patients with sarcopenia.
I asked GRG what to take for arthritis pain. Here are responses: # 1 on my list is Bioastin 12 mg per day; Regular conscious exercise is very helpful-I do karate; I would suggest you to test GDF11. My parents, aunt and enlarged family all benefited from severe arthritis. Here below a confirmation GDF11 is helping with arthritis.
From WebMD: Caffeine seems to help prevent gallstones and inflammation, among other medical problems. Some studies show that regular caffeine might help keep away certain neurological diseases, like Parkinson’s, Alzheimer’s, Huntington’s, multiple sclerosis, and epilepsy.
Semaglutide seems like the biggest innovation in weight loss in the past few decades: Daily weighing is also very helpful in weight control.
Masks cut asthma and allergies. A study by Israel’s Sheba Medical Center has concluded that the wearing of facemasks protected many citizens not only from Covid-19 but also from asthma and allergies.
Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial; Rapamycin caused a detrimental effect in overall skin structure, including a a thinner and more disorganized epidermis.”
BUT Topical rapamycin reduced the expression of the p16INK4A protein consistent with a reduction in cellular senescence. This change was accompanied by relative improvement in clinical appearance of the skin and histological markers of aging and by an increase in collagen VII, which is critical to the integrity of the basement membrane. These results indicate that rapamycin treatment is a potential anti-aging therapy with efficacy in humans.
