SUBJ: Treat video for the new year
SUBtitle: Lithium reverses Alzheimers
Thanks to Ralph: There are four stages in a man’s life. First you believe in Santa Claus; then you don’t believe in Santa Claus; then you play Santa Claus; and then you look like Santa Claus.
Lots of notes to start the New Year. Lots of good resolutions for a great year of health!
Links for new readers: 1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span
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All writings are to discuss with your physician. Full Disclaimer
SHORT NOTES:
1a..Triumph seems to prevent cancer
1b.. Treat video for the new year
2.. And another one!
3..Science Friday – Lithium reverses Alzheimers. See article
4..Higher dietary magnesium intake was associated with better sleep quality.
5..Sleep Compensation on Work-Free days Is Associated with Better Sleep Quality.
6..Inhibiting IL-11 extended lifespan 25% in mice.
7..The Ketogenic Diet: An Anti-Inflammatory Treatment for Schizophrenia.
8..Simultaneously target adiposity and inflammation.
9..Cellular Rejuvenation just Beyond Our Reach Today.
10..The use of profanity can help reduce the sensation of pain.
11..Restoring brain NAD+ homeostasis reverses advanced AD in mice.
12..Omega-3 fatty acids are a-effective strategy to reduce Alzheimer’s.
13..How your gene sequences are not your destiny. Thirteen minute video.
14..Every boost to the intellect, no matter how slight, can be a great blessing.
15..ADHD can be treated without medication.
16..Just 1% of those who partcipated in the attention-training computer-based training program developed PTSD.
17..RNA molecule to combat antibiotic resistance.
18..Custom gene editing shows promise for ultrarare diseases.
19..Two new drugs for gonorrhea showed their mettle in large clinical trials this year.
20..Crops can tolerate the scorching sunshine of a heat wave ideveloped in China.
21..Legacy PFAS in marine fish have declined.
22..A systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties.
23..Exploring the health benefits of olive oil.
LONG NOTES:
I developed Triumph to prevent the occurrence of bladder cancer which I had decades ago. I have also not had any other form of cancer develop. Taken two periods each month, it seems a worthwhile way to reduce the risk of cancer. Read more here.
Science Friday – Lithium reverses Alzheimers. See article
Association Between Dietary Magnesium Intake and Sleep Quality in Saudi University Students: A Cross-Sectional Study. Higher dietary magnesium intake was associated with better sleep quality, longer sleep duration, and reduced daytime dysfunction, highlighting the potential benefits of magnesium-rich diets for sleep health. Importantly, a significant sex disparity was observed in this university cohort, where females demonstrated poorer sleep quality than males. Therefore, dietary awareness programs that promote magnesium-rich food sources should be incorporated into student health initiatives to support improved sleep quality.
Sleep Compensation on Work-Free days Is Associated with Better Sleep Quality. These data suggest that work-related sleep loss should be avoided whenever possible or at least compensated for on work-free days in order to achieve not only sufficient sleep duration but also good sleep quality, which is pivotal for mental health and performance.
GRG just learned about this study, inhibiting IL-11 to extend lifespan. Mice were given antibodies against the inflammatory cytokine IL-11, and their lifespan was extended 25% (not the remaining lifespan but the full lifespan).
The Ketogenic Diet: An Anti-Inflammatory Treatment for Schizophrenia. The ketogenic diet (KD), a high-fat, very low-carbohydrate intervention has recently gained attention as a potential therapy for schizophrenia. Emerging clinical reports describe improvements in symptom burden, weight regulation, and sustained remission.
Comments on “Temporal Relationship Between Visceral Fat and Inflammation, and Their Joint Effect on Cardiometabolic Diseases: Evidence from the China Health and Retirement Longitudinal Study (CHARLS)”. We believe that our study provides a comprehensive insight for understanding the association and potential mechanisms between visceral fat accumulation, inflammation and cardiometabolic diseases. Approaches that simultaneously target adiposity and inflammation should yield greater benefits than targeting each individual risk factor.
From Kevin – Cellular Rejuvenation But Beyond Our Reach Today – a new study is pointing to a way to combat the aging of cells and the genesis of degenerative diseases. The research suggests that creating mini mitochondria factories helps to recharge damaged cells in a dish, providing proof-of-concept work that could potentially pave the way to new regenerative medicine therapies. the scientists were able to insert microscopic flower-shaped particles that served as carriers of molybdenum disulfide. When the particles are absorbed by stem cells in a petri dish, a molecular pathway was activated that boosted mitochondria production in cells. For further information check here.
The hypoalgesic effect of swearing has shown that the use of profanity can also help reduce the sensation of pain. This phenomenon is particularly strong in people who do not use such words on a regular basis.
Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain”. Severity of Alzheimer’s disease (AD) correlates with NAD+ homeostasis dysregulation
• Preserving brain NAD+ homeostasis prevents AD in mice
• Restoring brain NAD+ homeostasis reverses advanced AD in mice
Omega-3 Fatty Acids in Alzheimer’s Disease Prevention Among Elderly Women: Mechanisms of Action, Clinical Evidence, and the Critical Role of Early Intervention. Omega-3 fatty acids are a promising, non-invasive and cost-effective strategy to reduce the risk of Alzheimer’s in ageing women.
[GRG] how your gene sequences are not your destiny. Thirteen minute video.
Every boost to the intellect, no matter how slight, can be a great blessing. If dreams improve in quality as a consequence of fasting, that fact, being known, might cause people who otherwise wouldn’t fast to do so. Their health as well as their dreams could benefit.
ADHD can be treated without medication. (TY TPS) An Israeli-led international trial of ADHD children shows that a combination of cognitive training and brain stimulation modifies neural efficiency markers to a profile more typical of non-ADHD children. And some of the changes lasted weeks after treatment ended.
Reducing the risk of PTSD. A study by Tel Aviv University researchers, the IDF Medical Corps, and the US Department of Defense has found that out of more than 500 soldiers, just 1% of those who participated in the attention-training computer-based training program developed PTSD, compared to 5.3% in the control group.
RNA molecule to combat antibiotic resistance. (TY Nevet) Hebrew University of Jerusalem researchers have found a tiny RNA molecule called PreS that enables a bacteriophage (a bacteria-eating virus) to take control of a bacterial cell. The harmless phage uses it to grow but destroys the dangerous bacterium in the process.
Science 18 Dec pg 1222-Custom gene editing shows promise for ultrarare diseases. This year, a baby boy with a life-threatening metabolic condition became the world’s first patient to receive a personalized gene-editing. Soon after KJ’s birth, researchers raced to develop a base editor—a variation of the CRISPR gene-editing tool—that could fix a single spelling mistake in his faulty gene. After testing the bespoke base editor in cells and lab animals, the team won approval to treat KJ in February, when he was 6 months old, using an infusion of lipid nanoparticles to deliver genetic instructions for the base editor. By May, after two more doses, KJ could eat more protein, was gaining weight, and needed less medication to control his ammonia levels.
Science 18 Dec pg 1222 New weapons against a sexual scourge– Two new drugs for gonorrhea showed their mettle in large clinical trials this year, and both were approved this month by the U.S. Food and Drug Administration. The first new weapons against the sexually transmitted disease in decades, they come at a time when existing treatments are failing. Gonorrhea, which affects more than 80 million people annually, not only causes pain, genital discharge, and bleeding, but can also lead to serious complications, including pelvic inflammatory disease in women and infertility in both men and women. It increases patients’ risk of HIV infection and can cause blindness if newborn babies’ eyes become infected. Gonorrhea, which affects more than 80 million people annually, not only causes pain, genital discharge, and bleeding, but can also lead to serious complications, including pelvic inflammatory disease in women and infertility in both men and women. It increases patients’ risk of HIV infection and can cause blindness if newborn babies’ eyes become infected.
Science 18 Dec pg 1222 – Rice that beats the heat. rops can tolerate the scorching sunshine of a heat wave if they have enough water, but sweltering nights can spell particularly serious trouble. China bred a type of rice that is tolerant of heat. China invests in scientific research.
Science 18 Dec pg 1233 -Reevaluating PFAS exposure risks from marine fish
A modeling analysis suggests that legacy PFAS in marine fish have declined on a global scale. Known colloquially as “forever chemicals,” per- and polyfluoroalkyl substances (PFAS) are highly persistent chemicals that have been used extensively by industry and in consumer products (1). Epidemiological studies show that exposure to some PFAS can contribute to health problems such as cancers and metabolic changes in humans (2). Many PFAS used on land end up in the marine environment, where they can accumulate in aquatic food webs (3). However, the importance of marine seafood for human exposures remains unclear. On page 1305 of this issue, Qiu et al. (4) present a global modeling assessment of legacy PFAS exposure risks from marine fish consumption. The results suggest that human exposures to legacy PFAS from marine fish are generally low and have been reduced by the phasing out of legacy PFAS production.
Advancing functional foods: a systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties. Plant-derived exosome-like nanoparticles (PDENs), emerging as novel bioactive agents,
exhibit significant potential in food science and nutritional health. These nanoparticles, enriched with plant-specific biomolecules such as proteins, lipids, nucleic acids, and secondary metabolites, demonstrate unique cross-species regulatory capabilities, enabling interactions with mammalian cells and gut microbiota.
Exploring the health benefits of olive oil. Olive oil has long been a staple of Mediterranean cuisine, but its appeal extends far beyond flavor. It has many health benefits that are backed by decades of research. Studies link regular olive oil consumption to a wide range of benefits, from a lower risk of heart attack and stroke to improved erectile function.
