SUBJ: How to reduce inflammation
SUBtitle: Exercise as important as drugs to keep cancer at bay
Ill customs and bad advice are seldom forgotten. Benjamin Franklin Poor Richard’s Almanac
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SHORT NOTES:
1..Here is the result of my hours of effort for how to reduce inflammation.
2..Exercise as important as drugs in keeping cancer at bay.
3..Ultra-processed foods may rewire your brain to make you overeat.
4..From a reader: not only the vitamin C level in Japan helps. They are also thinner!
5..There is an unmet need for a robust theoretical framework in ageing research.
6..The longevity biotechnology sector is attracting high-profile investors.
7..Your body is constantly generating new cells, even neurons during old age.
8..I believed willpower was all that was needed. Now I know wantpower, canpower, done power.
9..The age-dependent increase in CD38 levels has been linked to NAD+ decline and mitochondrial dysfunction.
10..Vaccination with part of CD38 prevented a decline in total walking distance, maximal walking speed, grip strength, and hanging endurance in mice.
11..Orchestrated Objective Reduction suggests that quantum processes within microtubules—structures inside brain neurons—may be the seat of consciousness.
12..Therapeutic plasma exchange is considered the gold standard in evidence to reduce physical aging effects.
LONG NOTES:
A reader requested a review of how to reduce inflammation, one of the major causes of age-associated diseases including Alzheimer’s. Here is the result of hours of effort.
Exercise as important as drugs in keeping cancer at bay, suggests major new study. A new international study has found that a three-year exercise programme improved survival rates in colon cancer patients, as well as keeping the disease at bay.
Ultra-processed foods may rewire your brain to make you overeat. A study of 30,000 people found that a high consumption of ultra-processed foods is associated with structural changes in brain regions regulating eating behaviour, such as the hypothalamus, amygdala and right nucleus accumbens. This may lead to a cycle of overeating.
From a reader: Perhaps it is not only the vitamin C level in Japan that results in them having fewer strokes. The obesity rate in USA is 45.58% and the obesity rate in Japan is 5.8%. (maybe “Compared with the first quartile, the third and fourth quartiles of WHR [waist to hip ratio] had an increased risk of stroke adjusted for other risk factors and BMI. Those with WHR equal to or greater than the median had an overall OR of 3.0 for ischemic stroke even after adjustment for other risk factors and BMI.” So stay physically fit as well as getting plenty of vitamin C.
An overview of contemporary theories of ageing – There is a pressing and unmet need for a robust theoretical framework in ageing research. Elucidating the cellular and molecular mechanisms of ageing would be crucial for developing effective interventions that slow the ageing process and prevent its associated diseases.
Senolytics are under scrutiny in the quest to slow aging. As the world’s population continues to age, the ability to slow human aging pharmacologically would bring enormous health and medical benefits. It would also offer extraordinary financial rewards to any enterprise that was capable of delivering longevity in a pill. Because the major causes of mortality worldwide are age-related diseases (such as cancer, cardiovascular disease, type 2 diabetes and neurodegenerative disorders), delaying the onset of aging and age-related diseases is a dream as old as time. The longevity biotechnology sector has been expanding rapidly in recent years and attracting high-profile investors. One of the major anti-aging strategies involves targeting senescent cells. In the 1960s, Hayflick and Moorhead discovered that human cells in culture have a limited proliferative potential before becoming senescent owing to telomere shortening. In addition, cellular senescence can be triggered by oncogenes or various forms of stress..
Your body is constantly generating new cells. In your digestive tract, the colon’s lining turns over every five to seven days. Your red blood cells replace themselves every few weeks, skin cells about once a month. But certain organs are a big exception. Most of your neurons have the same lifespan as you do. In at least two parts of the brain, a subset of neuroscientists believe that neurons may continue to form throughout life–the hippocampus and the ventral striatum. In the hippocampus, a critical brain region for learning and memory, new cells emerge in some people into late adulthood, according to a study published July 3 in the journal Science.
I used to believe that willpower was all that was needed, and now I know there is more to it. First comes wantpower, a genuine desire for the outcome. Next, canpower is the belief that you can make it happen. Only then does willpower kick in. That is when donepower shows up. I am now following this order to change the results.
Many anti-aging strategies, such as supplementation, require regular, daily intake. A vaccine, on the other hand, is a therapeutic approach that, once administered, can have lasting effects. Anti-aging vaccination approaches have already been undertaken previously, and they were designed to target, among others, senescent T cells and the cells that line blood vessels (vascular endothelial cells). These researchers chose a different target: the widely researched CD38 protein expressed in several types of immune cells and tissues, which has multifunctional enzymatic activities related to NAD metabolism. The age-dependent increase in CD38 levels has been linked to NAD+ decline and mitochondrial dysfunction [4]. Previous research on targeting CD38 with small molecules for therapeutic purposes showed benefits improving glucose intolerance, physical dysfunction, and neuroinflammation [5, 6], while CD38 antibody research showed benefits against age-related syndromes, such as fibrosis, NAD+ deficiency, and cardiotoxicity [7-9], making it a promising target for a vaccine.
First, the researchers needed to find which part of CD38 would induce the strongest response from the immune system, thus making it the best candidate for a vaccine. While the researchers encourage future studies to test different sequences, they limited themselves to three amino acid sequences with which to create three peptide vaccines. After a few weeks, they tested how the immune systems of mice responded to the vaccines and chose the one that spurred the strongest response.
Physically stronger and cognitively younger
The researchers immunized a group of 12-month-old mice with the chosen vaccine. At 15-18 months old, the researchers analyzed the mice’s healthspan, then immunized them again at 18 months and 3 weeks of age and euthanized them at 20 months to collect tissues for further assessment. The mice showed a strong immune response to the vaccination, translating into physical and cognitive health improvements in aged mice. The researchers observed that vaccination prevented a decline in total walking distance, maximal walking speed, grip strength, and hanging endurance in both male and female animals.
Mainstream neuroscience has long operated on the assumption that consciousness is an “emergent property” of complex brain activity. But this view has never been able to answer the hard problem of consciousness: How does matter produce subjective experience? How does electrochemical activity lead to love, music, memory, or awe?
Some researchers are challenging that very premise. Sir Roger Penrose, a physicist, and Dr. Stuart Hameroff, an anesthesiologist, proposed a theory called Orch-OR (Orchestrated Objective Reduction), which suggests that quantum processes within microtubules—structures inside brain neurons—may be the seat of consciousness. Quantum processes don’t obey classical physics. They can be nonlocal, indeterminate, and even timeless. This raises a profound possibility: consciousness may not be generated by the brain, but may exist independently, with the brain acting more like a radio than a generator.
Therapeutic plasma exchange is the procedure I am performing in my offices in La Jolla, California. The Buck Institute is considered the gold standard in evidence based human and animal clinical studies and scientific publications. Please feel free to share this with anyone you feel might be interested.
