SUBJ: “The first person to live to 150 is alive today” – Me (Roc)
SUBtitle: Different people require 4 to 12 hrs sleep
With the old Almanac and the old Year, Leave thy old Vices, tho’ ever so dear. Benjamin Franklin Poor Richard’s Almanac – providing future intro quotes
Links for new readers: 1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span 3) Recent important nutrition news. 4) A financial contribution to this newsletter is less expensive and better for your health than a multivitamin. Please use this new Link to subscribe to newsletter for $52/year. It will remind you annually to resubscribe. Sorry I am not set up as a non-profit. Donation link to a fund raiser for Nutrition Investigator travel to present research at professional meetings. To be removed from the nutrition list distribution, please email ordman@beloit.edu SUBJ: remove from list
SHORT NOTES:
1..”The first person to live to 150 is alive today” – Me (Roc)
2..Requirement for sleep for people is actually a bell curve, from 4 to 12 hours.
3..Exercise improved survival for colon cancer survivors after chemotherapy.
4..Do you know a marketing agent to help me get more newsletter readers?
5..Risk Factors for Dementia: Diabetes, alcohol and exposure to air pollution.
6..α-ketoglutaric acid supplements delay cellular senescence in most cases.
7..Over a quarter of people on a diet do not lose weight but gain other health benefits.
8..US longevity academy working to advance aging research and improve lives.
9..Tech to treat mental illness.
10.. Lembas contains a bioactive peptide that regulates appetite and metabolism.
11..SELARSDI treats adult and pediatric psoriatic arthritis and plaque psoriasis, as well as Crohn’s disease, and ulcerative colitis.
12..Between 3.2 and 20% of older men produce lower levels of testosterone.
13..Two children whose IQs were insufficiently high to be considered intelligent won Nobel Prizes in Physics.
14..75% of people agree scientific methods are best to evaluate truth.
15..Do longevity drugs work? Best advice: eat wisely, drink moderately, exercise.
16..Vitamins A and D were significantly lower in COVID-19 patients.
17..Anxiety was significantly associated with periodontitis in university students.
18..Weight gain in early adulthood gives a higher risk of obstructive sleep apnea.
19..Sleep disturbance in Parkinson’s is a common non-motor complication.
LONG NOTES:
“The first person to live to 150 is alive today” – Dr. David Sinclair (I think it is me, Nutrition Investigator Roc) I wanted to share this interview with Dr. David Sinclair, a devoted longevity researcher. In this interview, he also said that: “In 10 years we take a pill for 4 weeks and we get younger.”
Science 26 June pg 1383 – Exercise improved survival for colon cancer survivors after chemotherapy, compared to those who only had health nutrition education.
Sleep: The 8 hour myth. I, Roc, actually studied this back in 1980. Requirement for sleep for people is actually a bell curve, from 4 to 12 hours, average 8. I need 9, the Chair of Biology only needed 4. Unfair!
Marketing agent? I have been advised that to get more subscribers to my newsletter, I should find a marketing agent to assist in getting the word out. Are you perchance knowledgeable about helping me get the word out about my newsletter? Please RSVP if you or someone you know could help me.
AARP: 3 Big Risk Factors for Dementia to Avoid: Diabetes, alcohol consumption (measured by frequency) and exposure to air pollution are the most harmful modifiable risk factors for dementia out of 15 that were studied in a recent report published in the journal Nature Communications.
α-ketoglutaric acid (AKG) diminishes in cells with aging. Administering AKG to stem cells delays cellular senescence in most cases. Exactly why this occurs has been biochemically explained. A small molecule increases AKG and has physical benefits in mice. Cell Reports.
Better health even if no weight lost. A study by researchers at Israel’s Ben-Gurion University has found that although over a quarter of people on a diet do not lose weight, they gain other health benefits. These include higher “good” cholesterol, lower leptin levels, and reduced visceral and liver fat. So be positive!
Israeli joins US longevity academy. The US Academy for Health and Lifespan Research (AHLR) has inducted Prof. Haim Cohen of Israel’s Bar-Ilan University. “It’s inspiring to be part of such a remarkable group of scientists, all working to advance aging research and improve lives around the world,” said Prof. Cohen.
Tech to treat mental illness. Israelis have developed many digital platforms to aid mental health. They include Kai.ai, physiological approaches from Calmigo (see here), passive sensing technologies by Behavidence, and the digitally scaled trauma response of NATAL (see here), Israel’s Trauma and Resiliency Centre.
Lembas (named after elves bread in the movie Lord of the Rings) has developed the GLP-1 Edge dietary supplement. It contains a bioactive peptide that triggers the body’s secretion of GLP-1 and other gut hormones that regulate appetite and metabolism.
The US FDA has approved SELARSDI that Israel’s Teva has developed with Europe’s Alvotech. SELARSDI is a biosimilar (see here previously) to the costly branded Stelara. It treats adult and pediatric psoriatic arthritis and plaque psoriasis, as well as Crohn’s disease, and ulcerative colitis.
The Economist June 21, pg 70-Is the menopause real? Between 3.2 and 20% of older men produce lower levels of testosterone. To testerone replacement therapy has pros and cons. Gain muscle, lose fat, recover from exercise, but go bald, become infertile.
New Yorker June 23, pg 59-When Terman developed the IQ test, two children whose IQs were insufficiently high to be considered intelligent went on to win Nobel Prizes in Physics.
The Economist June 28, pg 70: 75% of people agree scientific methods are best to evaluate truth. Pg 70-Do longevity drugs work? Studies suggest rapamycin is as effective as long term fasting. Fasting inhibits mTOR pathway that causes inflammation. Inhibiting mTOR promotes autophagy, where cells clear out accumulated crud, which is life-enhancing. Best longevity advice: eat wisely, drink moderately,d exercise. Regularly, sleep well, and don’t smoke.
Vitamins A and D were significantly lower in COVID-19 patients, and lower vitamins A and D were independently linked with a high risk of C
Anxiety was significantly associated with periodontitis in university students, highlighting the importance of addressing anxiety as part of periodontal disease prevention and management strategies in this population.
Weight gain in early adulthood was associated with a higher risk of obstructive sleep apnea (OSA) and subsequent mortality, regardless of weight status in later life. Therefore, maintaining a normal body weight in early adulthood should be actively promoted to prevent OSA and improve prognosis.
Sleep disturbance in Parkinson’s disease (PD) is recognized to be one of the most common non-motor complications. It occurs before disease onset as a prodromal symptom, during and then throughout the disease course. Causes are multifactorial and can be multiple in the same patient. Specific sleep disorders that are known to occur in those with Parkinson’s disease include REM sleep behavior disorder, sleep disordered breathing including obstructive sleep apnea, restless legs and periodic limb movements, nightmare disorder, insomnia alongside direct side-effects of the medication used for therapy.
