SUBJ: coffee with no cream or sugar to reduce inflammation
SUBtitle: older people prone to dementia than in the past
Love yourself first, and everything else falls in line. -Lucille Ball
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SHORT NOTES:
1..Enjoy your coffee with no cream or sugar to reduce inflammation.
2..Today’s older people seem to be less prone to dementia than in the past.
3..Centenarians have doubled roughly every ten years.
4..Dextrose prolotherapy on patients diagnosed with knee osteoarthritis works.
5..Osteoarthritis (OA) in the knee relieved by intra-articular injection of a virus.
6..GPR45 joins a complex brigade of neural GPCRs to control obesity.
7..Beneficial effects of taurine depend on a range of variables and individual context.
8..Telomir-1 Restores Youthful Gene Regulation in mice.
9..The CAR-T cancer treatment is saving thousands of lives today.
10..Current treatments from Israel’s Teva include Austedo (involuntary movements), Ajovy (migraine), and Uzedy (schizophrenia).
11..Inflammation intertwined and affected by aging.
12..Association between a later bedtime and cognitive decline among the highly educated.
13..Enhancing sleep and mental health to prevent and manage pain and frailty.
14..Quercetin-Based Strategies for Ocular Diseases in Older Adults.
15..The Good – The many “peaceful” protests that are occurring across the country.
16..The Bad – The “Great Big Beautiful” bill that decimates Medicaid.
17..The Ugly – The destruction of “science” as a core foundation for the USA.
LONG NOTES:
Economist 7 June pg 73: Enjoy your coffee with no cream or sugar! Drinking coffee reduces inflammation. It aarrests tumor growth by preventing blood vessel growth, and inhibits the formantiopn of carcinogens. Post-menopausal women who drink 3 or 4 cups a day were significantly less likely to get breast cancer than those who drank only two, and three or more cups daily reduced risk of liver cancer. It reduces the risk of psychiatric and neurological diseases like Alzhemiers, Parkinsons, and depression. People who drank 1 to 3 cups/d were 15% less likely to die over a decade than those who didn’t, unless they add cream or sugar.
While the overall prevalence of dementia might be rising due to population aging, a study has found that today’s older people seem to be less prone to dementia than in the past [1]. For instance, among respondents aged 81 to 85, dementia rates differed notably by birth cohort and region. In the United States, 25.1% of those born between 1890 and 1913 were diagnosed with dementia, compared to just 15.5% among those born from 1939 to 1943. “There has been a lot of improvement in education, particularly for women, if, for example, we compare to the baby boomer generation,” she said. “We’ve seen improvements in cardiovascular health, better control of blood pressure and cholesterol, all risk factors for dementia.”
Over the last few generations, the idea of celebrating a 100th birthday has moved from fairy-tale territory to neighborhood reality. Centenarians are now the fastest-growing age group. Their ranks have doubled roughly every ten years since 1950, and projections point to a fivefold jump between 2022 and 2050. in one Japanese study, people with the lowest inflammation were more likely to reach 100. Because AMORIS records stretched back 35 years, the Karolinska group could watch trends instead of single frames. They combed through twelve blood-based indicators tied to metabolism, liver and kidney function, nutrition, inflammation, and anemia. Small tweaks – longer walks, fewer sugary drinks, varied protein, mindful stress relief – nudge those numbers toward the safer middle.
The Journal of Nursing and Midwifery says in cases of knee osteoarthritis, “leg exercise reduces pain and improves function”. (3) According to scientific studies, exercise and recreational activities do not cause joint wear and tear. Khateri, Sorour, et al. “The effect of dextrose prolotherapy on patients diagnosed with knee osteoarthritis: A comprehensive systematic review and meta‐analysis of interventional studies.” Health Science Reports 7.6 (2024): e2145. Prolotherapy uses a sugar-based solution (dextrose) to create a mild irritant, triggering the body’s natural healing response. Drawing from the data analysis performed in this meta-analysis, it is apparent that dextrose prolotherapy exhibits promising effectiveness in reducing joint pain and stiffness, as well as improving functional performance in individuals suffering from KOA. Injecting a mild irritant (like dextrose) into the affected area stimulates inflammation, which in turn triggers the body’s natural healing process. This process can lead to the deposition of new collagen and the strengthening of tendons and ligaments. Some studies suggest that PRP may be more effective than prolotherapy for certain conditions, such as carpal tunnel syndrome and knee osteoarthritis. However, other studies have shown similar efficacy for both treatments.
Science 5 June pg 1036- Osteoarthritis (OA) in the knee joint is typically accompanied by elevations in inflammatory signaling in the intra-articular space. Protein and small-molecule therapies delivered to the intra-articular space are cleared rapidly from the joint, so new strategies to enrich therapeutics for long-term treatment are needed. De La Vega et al. have taken a step toward a safe gene therapy for patients with OA in a first-in-human, single-center, phase 1 clinical trial to test the safety of intra-articular delivery of an adeno-associated virus expressing interleukin 1 receptor antagonist (IL-1Ra), an endogenous inhibitor of the proinflammatory cytokine IL-1. In a dose-escalation trial in nine participants, the authors observed that a single intra-articular injection of the gene product led to an increase in IL-1Ra in the synovial fluid that remained elevated for up to a year. There were no serious adverse events related to the gene delivery. These data support the progression to larger-scale trials of this gene therapy to further explore the potential for its long-term therapeutic benefit for OA.
Sci. Transl. Med. (2025) 10.1126/scitranslmed.adu9804
pg 1026-GPR445: Xun et al. report obesity-associated alleles of G protein–coupled receptor 45 (GPR45) in mice. They found that GPR45 is localized to primary cilia in neurons within a key brain feeding control center, the paraventricular nucleus of the hypothalamus (1). GPR45 thus joins a complex brigade of neural GPCRs that regulate feeding and is poised to become part of the armamentarium of druggable receptors now actively helping patients control obesity; pg 1039-Some studies (including work published in 2023 by Singh et al.) have indicated that taurine concentrations decline with age, and supplementation has been suggested to improve both healthspan and lifespan. Fernandez et al. now report results in mice, nonhuman primates, and three distinct large human cohorts studied longitudinally (i.e., with repeated measurements of the same individuals) that yield a more complex picture. The authors found large interindividual variation in circulating taurine concentrations and an increase in taurine concentrations for most cohorts during adult life. There was also no clear association of taurine concentrations with measures of health status. Thus, the possible beneficial effects of taurine supplementation are likely to depend on a range of variables and individual context. —L. Bryan Ray
[study][zebrafish]: “Telomir Pharmaceuticals Announces Telomir-1 Resets
the Body’s Epigenetic Clock, Reverses DNA Methylation, and Restores
Youthful Gene Regulation in an Ultra-Rare Accelerated Aging Animal Model
of Werner Syndrome”
Making an Israeli invention even better. The Israeli-invented CAR-T cancer treatment is saving thousands of lives today. The patient’s own immune T-cells are extracted, increased and put back in the patient. Ben Gurion University researchers have extended T-cell longevity using different shaped surfaces for the growth medium.
Current treatments from Israel’s Teva include Austedo (involuntary movements), Ajovy (migraine), and Uzedy (schizophrenia). It expects soon to launch Olanzapine (schizophrenia), Duvakitug (IBD), Dari (asthma), Emrusolmin (Multiple System Atrophy), and has fast-tracked TEV-53408 (Celiac).
We’ve known that our immune system and the process of inflammation are tightly intertwined and are affected by aging. The terms immunosenescence and inflammaging have been coined to reflect that. In the past few weeks there have been a number of important publications that tell us much more about their pivotal role for influencing the major age-related diseases and our healthspan. In this edition of Ground Truths I will review 4 key papers and present a unified model that brings the findings together.
A recent analysis of over 20,000 middle-aged and older adults showed an association between a later chronotype (‘night owls’) and cognitive decline among highly educated people [1]
Association Between Pain and Frailty in Middle-Aged and Older Patients: The Mediating Roles of Sleep and Mood. Pain and frailty are significantly social concerns negatively affecting physical and mental health in middle-aged and older population. This study aimed to investigate the association between pain and frailty, with a particular focus on the mediating roles of sleep and mood. Our research provided evidence supporting the robust association between pain and frailty and offered new sights into potential strategies by enhancing sleep quality and mental health for preventing and managing both pain and frailty.
Targeting Senescence, Oxidative Stress, and Inflammation: Quercetin-Based Strategies for Ocular Diseases in Older Adults. Quercetin, a flavonol abundant in fruits and vegetables, has attracted significant attention for its senotherapeutic effects, which involve the selective elimination of senescent cells and the modulation of pro-inflammatory phenotypes that contribute to age-related dysfunctions. These actions, together with its antioxidant, anti-inflammatory, neuroprotective, and anti-angiogenic properties, make quercetin a promising strategy for ocular diseases associated with visual impairment in older adults such as age-related macular degeneration, cataract, diabetic retinopathy, and glaucoma. Combining quercetin with established treatments, such as anti-vascular endothelial growth factor (VEGF) agents and neuroprotective drugs, may enhance its therapeutic potential in managing and possibly reversing age-related ophthalmic disorders.
From Kevin: The Good – The many “peaceful” protests that are occurring across the country. There is NO NEED for violence!
The Bad – The “Great Big Beautiful” bill pending before Congress that taxes the poor by decimating Medicaid and, therefore, creating a form of “tax” on the poor while simultaneously giving a massive tax break to wealthy Americans.
The Ugly – The ongoing destruction of “science” as a core foundation for the work of the U.S. Department of Health and Human Services by Secretary Robert F. Kennedy, Jr.
