As Much As I Want Life to be Fair, I Don’t Need It!
SUBJ: Get exercise! Over age 60, 95% have 1 chronic condition
SUBtitle: 79% have 2 chronic conditions
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SHORT NOTES:
1.. For Americans aged sixty years and above, 95 percent have at least one chronic disease, and 79 percent have at least two chronic conditions. Slowing down aging for one year would save $38 trillion in medical costs.
2..Study of elder adults showed more than 32% of incident dementia over 8 years could be attributed to hearing loss.
3..Medium mattress firmness offers best outcomes for those with a moderate BMI.
4..7 body parts to care for after age 50.
5..Aspirin stabilizes intervertebral disc degeneration.
6..Plasma exchange combined with immunoglobulin reduced biological age.
7..Plasma derived from younger donors has beneficial effects.
8..Review on the Neural Circuits for Sleep and Pain Control.
9..Depressive symptoms are associated with nightmares.
10..Exploring the Top 50 Drugs Associated with Restless Legs Syndrome.
11..BMI did not correlate with sleep apnea.
12..1 in 8 men will get Prostate cancer, the second-most common cancer behind breast cancer. [If you take Triumph, you likely reduce the risk for bladder and prostate cancer.]
13..Robert F. Kennedy, Jr. is an unqualified leader who is simply exerting power.
14..US dentists and pediatricians believe fluoride adds to the decline in cavities.
15.. “30,000 fewer U.S. drug overdose deaths in 2024,” a reduction of 27% from 2023.
16..Items that many eat on a regular basis contribute to a reduction in gut health.
LONG NOTES:
Science 29 May pg 921: Look beyond the longevity drips and supplements. There is a path to living longer and healthier that doesn’t require reversing the aging process. There are 120,000 people over 100 in the US today, and in 2060 there may be 600,000. (I will be one of them at 111!). Life expectancy (LE) and health-adjusted life expectancy (known as HALE) are quite different. Over time, the gap between LE and HALE is getting larger, with chronic illnesses on the rise in the United States. For Americans aged sixty years and above, 95 percent have at least one chronic disease, such as heart disease or diabetes, and 79 percent have at least two chronic conditions. That’s why the notion that slowing down aging for one year, a small increase in LE, would be worth $38 trillion.
As an individual who is reaching the “elder” stage of life, I’ve become much more cognizant of not only dietary intake (SEE above note on gut microbiota ), I have also become aware of the literature on “hearing loss” and its association with dementia. In a recent study reported in MedPage Today a reported dementia may be accelerated with hearing lost playing “a bigger role in dementia than previously thought.” A sampling of about 3,000 elder adults revealed that upwards of 32% of incident dementia over a period of 8 years could be attributed to audiometric hearing loss.
This study provides evidence that mattress firmness significantly influences sleep quality, with medium firmness offering optimal outcomes for individuals with a moderate BMI. The findings contribute to the development of scientifically informed mattress designs, including smart mattresses aimed at improving sleep quality.
AARP: 7 body parts to care for after age 50: eyes checked every 1-3 yrs; teeth and gums (dry mouth); feet (bunions); pelvic floor (Abdominal muscles, hip muscles and spinal muscles); hips and knees (If your joint is already giving you trouble, keep moving), ears (Just 2 percent of Americans ages 45 to 54 have serious hearing loss. But that changes over time, rising to half of people 75 and older), abdominal core (Think of sucking everything in and pulling your belly button toward your spine to fully engage the muscles).
Aspirin stabilizes the targeting of GPX4, thereby inhibiting ferroptosis and exerting therapeutic effects on intervertebral disc degeneration.
Study in Aging Cell shows that therapeutic plasma exchange combined with
intravenous immunoglobulin reduced biological age on average by 2.6
years, as measured by multi-omics biomarkers. A first-of-its-kind clinical trial clinical trial shows that therapeutic plasma exchange (TPE) combined with intravenous immunoglobin reduced biological age on average by 2.6 years, as measured by multi-omic biomarkers.
A placebo-controlled clinical trial, with results published in Aging Cell, has determined that plasma derived from younger donors has beneficial effects when combined with immunoglobulin, according to multiple epigenetic clocks and -omics. Effects of Fluid Intake on Sleep Duration and Quality Among Healthy Adults
What Links Sleep and Neuropathic Pain?: A Literature Review on the Neural Circuits for Sleep and Pain Control. Neuropathic pain (NP), arising from lesions or diseases of the sensory nervous system, significantly disrupts sleep, creating a feedback loop where pain and sleep disturbances exacerbate each other. This review seeks to disentangle these complex relationships by providing a detailed overview of the anatomical pathways involved in NP, extending from the peripheral to the central nervous system. Additionally, it examines the neurocircuits that govern sleep-wake cycles and their interaction with pain pathways. By illuminating these connections, this review aims to deepen our understanding of how sleep influences NP, ultimately guiding the development of more effective strategies for managing NP and its associated sleep disturbances to improve the quality of life for those affected.
Dreams and Nightmares in Early Pregnancy: A Comparative Study with a Control Group. Contrary to expectations, first-trimester pregnant women had fewer nightmares than non-pregnant women. However, the results are coherent with the finding that parasomnia-like events decrease during pregnancy. The rapid hormonal changes and specific sleep and emotional features of this stage of gestation may explain the lower presence of nightmares as compared to our control group. Moreover, we confirmed a crucial role of dream attitude in recalling nightmares, suggesting that some stable, trait-like features may contribute to nightmare experiences independently of pregnancy status. Our results also confirmed, according to the Continuity hypothesis, that depressive symptoms are associated with nightmares. Also, the presence of lucid dreaming in association with nightmares may be interpreted as an attempt to cope with unpleasant emotions.
Exploring the Top 50 Drugs Associated with Restless Legs Syndrome Based on the FDA Data from 2004 to 2024. A total of 16,410 reports were linked to RLS, with sodium oxybate being the most common (648 cases, 3.9%). Nervous system medications comprised 31.3% of cases. Of the 50 drugs, 27 showed valid risk signals; only 6 were consistent with FDA labels. Risk factors included age under 44, weight over 64 kg, female gender, and 24 specific drugs. TTO analysis revealed that most drugs exhibited early onset patterns.
The Association of Body Mass Index and Adiposity-Estimating Equations with Measures of Obstructive Sleep Apnea Severity: A Cross-Sectional Study. BMI demonstrated poor discriminative ability for moderate/severe and severe OSA.
Economist:The argument over prostate screening: Prostate cancer is the second-most common cancer behind breast cancer. 1 in 8 men will get it. PSA test is not very reliable. It is often double checked with a biopsy. But only 20% of cancers need aggressive treatment. Thus men over 70 should not get tested. [If you take Triumph, you likely reduce the risk for bladder and prostate cancer.]
Our newly minted DHHS Secretary – Robert F. Kennedy, Jr. – made a unilateral decision this past week to disallow COVID vaccinations for women who are pregnant and children. Not only was the US Centers for Disease Control not in the loop, but the combination of the Secretary plus the head of the Food and Drug Administration (FDA) simply reversed all of the recommendations on the topic unilaterally!! This is the implementation of the “de-sciencing of health care” by an unqualified leader who is simply exerting power without any rational data and/or process in place.
The vast majority of USA dentists and pediatricians believe that fluoride provided in small doses, akin to what you would find in the water of USA cities’ water supply, has contributed to the marked decline since 1945.
In a recent data release by the US Centers for Disease Control (CDC), there were “30,000 fewer U.S. drug overdose deaths in 2024,” or a marked reduction of 27% from 2023 when the nation experienced 110,000 deaths.”
There is a framework that’s been developed by dietetics experts referred to as the Dietary Index for Gut Microbiota (DIGM). Items that many of us eat on a regular basis, which contribute to a reduction in gut health, include the following:
Refined Grains – such as white bread and plain white rice, Processed Meats – sausage, bacon (Oy Vey!!!), deli meats, and any other meats that have high levels of nitrates, Red Meat – primarily from the high-fat red meats or highly processed meats due to the microbial shifts that are created in our intestinal systems, High-Fat Diets – where the percent of caloric intake exceeds 40% derived from fat.
