SUBJ: Topical product containing OS-01may reduce wrinkles.
SUBtitle: AARP hyperbolic: supplements they warned about are mostly safe
Etre indifferent, c’est mourir. Esperer, c’est deja jouir. –fortune cookie
Links for new readers: 1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span 3) Recent important nutrition news. 4) A financial contribution to this newsletter is less expensive and better for your health than a multivitamin. Please use this new Link to subscribe to newsletter for $52/year. It will remind you annually to resubscribe. Sorry I am not set up as a non-profit. Donation link to a fund raiser for Nutrition Investigator travel to present research at professional meetings.
SHORT NOTES:
1..Topical product containing OS-01may reduce wrinkles.
2..AARP report last week was hyperbolic and I apologize for frightening users of these supplements. Ashwagandha, Black cohosh, Garcinia cambogi, Green tea extract, Red yeast rice, Turmeric/curcumin.
3..Another kind of microbe has displayed worrying levels of resistance: fungi.
4..How to form good habits, and break bad ones: trick your brain.
5..When it comes to habit-formation, good old-fashioned willpower is the way forward.
6..The Diabeatles – Greatest Hits (The Beatles / Wilford Brimley Parody).
7..Advanced Bowen Therapy – Resetting Full Body Pain and Tension in 5 Minutes.
8..Kidney cancer solution using cryoablation (freezing). 88.7% non-reoccurrence rate.
9..Blood test for early detection of Parkinson’s.
10..The radiation treatment used to treat skin cancer, prostate cancer, pancreatic cancer, liver cancer, and lung cancer.
11..If you’re sick, see a computer. AI more accurate than physicians.
12..Exercise Boosts Brain Function Across All Ages.
13..Even the richest Americans face shorter lifespans than their European counterparts.
14..Microplastics in air enter plant leaves, pass to animals & humans.
15..Drinking from plastic bottles linked to high blood pressure and heart problems.
16..Reduce Cardiac Arrest: Don’t be fat; don’t smoke; don’t eat processed meat…
17..Media outlets emphasized that champagne and white wine prevent heart attacks.
18..Predictive Models for Inflammatory Bowel Disease Diagnosis.
19..Sleep Deprivation Impairs Interpersonal Trust.
20..Sleep Apnea contributes to gait disorders.
21..Napping effectively enhances the aerobic and anaerobic athletic performance.
22..How Awakenings During Sleep Influence Dream Recall.
23..Drug Target and Potential Therapeutic Direction for Sleep Apnea Syndrome.
LONG NOTES:
This may reduce wrinkles. A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the skin’s barrier function and multiple aging biomarkers [1]. As people age, senescent cells build up in various tissues, such as the skin. These old, damaged cells release persistent inflammatory signals, which harm tissue integrity and function. These inflammatory signals are collectively called the senescence-associated secretory phenotype (SASP).
After the AARP report about six hazardous nutraceuticals, I was asked to explore them. Below are notes and links to longer investigations I made. Basically the AARP report was hyperbolic and I apologize for frightening users of those supplements.
Ashwagandha –Good for stress and anxiety. Taking 250–500 milligrams (mg) per day for at least one month may be beneficial.
Black cohosh –commonly used for menopausal symptoms. Dosage – 40 mg black cohosh root/rhizome (extracted with isopropyl alcohol) per daily dose of two tablets
Garcinia cambogi –Very impressive! used in the treatment of obesity. treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day). Some people who take garcinia cambogia supplements report negative effects like nausea, headache, and other stomach and intestinal symptoms and in the upper respiratory trac
Green tea extract –Green tea is fabulous for healthspan. Drinking up to 6 cups daily increases health span. A 250 mg capsule of green tea extract is often considered equivalent to one cup of green tea. Liver injury from green tea is rare.
Red yeast rice –The extract of red yeast rice (RYR) is the most effective cholesterol-lowering nutraceutical on the market. In particular, its effectiveness is directly related to the amount of monacolin K within the extract (up to 10 mg/day). safe and effective.
Turmeric/curcumin –Turmeric and its purified extract curcumin are also used medically for their purported antiinflammatory and antioxidant effects to treat a wide variety of conditions and for general health and wellness including reducing risk for cancer. One reason given for the safety and lack of hepatotoxicity of curcumin was that it is poorly absorbed by the oral route
The Economist Apr 26, pg 69-Breaking the mold! FOR MANY people, the looming threat of antimicrobial resistance has become synonymous with bacteria that can withstand antibiotics. That conflation makes sense. Bacterial infections kill almost 8m people a year, and most are associated with resistant bacteria. But in recent years another kind of microbe has displayed worrying levels of resistance: fungi.
Dangerous fungal infections are rising across the world, especially among the growing number of people with weak immune systems. These infections—systemic, lethal infestations of the body’s deep tissues and organs—have little in common with the inconveniences of everyday fungal pathogens such as athlete’s foot and ringworm. They are now responsible for an estimated 7m life-threatening infections and more than 2.5m deaths a year. Like their bacterial counterparts, fungi are evolving resistance to the drugs that are meant to fight them. The good news is that more powerful classes of medicines are finally starting to emerge.
Although there are more than a dozen different types of antibiotics, there are currently only three main classes of antifungals: polyenes, azoles and echinocandins. Each attacks a different part of a fungus’s cell membrane or cell wall, protective structures that surround the fungal cell and without which it cannot survive. The last of these classes, the echinocandins, were introduced in the early 2000s and since then no new classes have been approved. Part of the reason is that fungi are much more closely related to animals than bacteria are: anything that kills a fungus may well kill the cells it has infected.
Pg 71- How to form good habits, and break bad ones: trick your brain. To break an unwanted habit, on the other hand, consider removing familiar stimuli. Moving house is known to help—though calling in the removal vans is a drastic approach to resolution-keeping. The nicotine inhaled by smoking tobacco—a type of habit so powerful that it has a special name, “addiction”—stimulates dopamine production directly. This is something natural selection could not have foreseen. Non-addictive habits like procrastination are harder to explain.
In the end, though, all this science continues to support the idea that, when it comes to habit-formation, good old-fashioned willpower is the way forward. As the old joke has it: “How many psychoanalysts does it take to change a light bulb? Only one, but the light bulb has to really want to change.”
The Diabeatles – Greatest Hits (The Beatles / Wilford Brimley Parody)
Get a Wimpy Alien or other And You Films T-Shirt today! https://teespring.com/stores/andyoufilms Want to help us out? Now you can by becoming a patron for only $1 at https://www.patreon.com/andyoufilms All donations go right back into making more parodies for you to enjoy! SUBSCRIBE TO SEE A NEW PARODY EVERY MONTH! Video inspired by “The …
If you or someone you know is a personal trainer, check out the Advanced Bowen Therapy Newsletter from Marina. She created a handy guide for therapists of all shapes and sizes, body workers and personal trainers called Resetting Full Body Pain and Tension in Five Minutes that will help clients, friends of family get pain and tension free so they can do what makes them happy. We thought you might like it. Click the link to grab the guide: www.myoresetx.com/offer
Good results of IceCure’s kidney cancer solution. (TY Atid-EDI) Israel’s IceCure (see here previously) is already saving many lives by destroying tumors using cryoablation (freezing). Its most recent ICESECRET study on 114 kidney cancer patients with small renal masses (SRM) showed an 88.7% non-reoccurrence rate.
Blood test for early detection of Parkinson’s. A team led by Hebrew University of Jerusalem researchers has developed the first ever blood test capable of detecting Parkinson’s disease, even before symptoms emerge. The test identifies transfer RNA fragments unique to the neurodegenerative disease.
Brain cancer treatment trial. The radiation treatment from Israel’s Alpha Tau (see here previously) has been used to treat skin cancer, prostate cancer, pancreatic cancer, liver cancer, and lung cancer. It now has had US FDA approval to initiate a trial for patients with recurrent glioblastoma (brain cancer).
If you’re sick, see a computer. A new study from Tel Aviv University found that diagnoses and treatment recommendations given by AI were more accurate than those of physicians. Of 461 online patient visits, AI was rated as good in 77% of cases but only 67% by doctors. Bad AI ratings were 2.8%; Bad doctors were at 4.6%.
Exercise Boosts Brain Function Across All Ages, Massive Study Confirms. Exercise significantly improved general cognition, and this was true across all age groups and exercise modalities.
Even the richest Americans face shorter lifespans than their European counterparts, study finds. At every wealth level in the U.S., mortality rates were higher than those in the parts of Europe the researchers studied. In some cases, the wealthiest Americans have survival rates on par with the poorest Europeans in western parts of Europe, such as Germany, France and the Netherlands.
Microplastics in air enter plant leaves, pass to animals & humans: Study. Plant leaves absorbed microplastics and nanoplastics directly from the air, with the particles subsequently entering the food chain through herbivores and crops consumed by humans, a new study found.
Drinking from plastic bottles directly linked to high blood pressure and heart problems. Plastic containers and packaging are everywhere, as many people rely on them for food storage, convenience, and hydration. [I recently switched to metal bottles for drinking water. No more disposable plastics.]
Modifiable Risk Factors and Attributable Burden of Cardiac Arrest: An Exposome-wide and Mendelian Randomization Analysis Don’t be fat; don’t smoke; don’t eat processed meat; and it’s good to eat more whole grains, fruits and vegetables. And if you eat dairy, you should aim for low-fat or skim. The consensus on those are solid. But I noticed a few strange things.
–Popular media outlets emphasized the finding that champagne and white wine were found to prevent heart attacks. Yes, but the correlation with red wine was at least as strong. As has been found in dozens of studies, “It’s the alcohol, stupid.” As long as you keep it in moderation. “Recently, emerging evidence has reported a U-shaped association of drinking alcohol with cardiovascular diseases.
Development and Validation of Predictive Models for Inflammatory Bowel Disease Diagnosis: A Machine Learning and Nomogram-Based Approach. Inflammatory bowel disease (IBD) is a chronic, incurable gastrointestinal disease without a gold standard for diagnosis. This study aimed to develop predictive models for diagnosing IBD, Crohn’s disease (CD), and Ulcerative colitis (UC) by combining two approaches: machine learning (ML) and traditional nomogram models. This study utilized three cohorts and developed risk prediction models for IBD, CD, and UC with good diagnostic capability, based on conventional laboratory data using ML and nomogram.
Sleep Deprivation Selectively Impairs Interpersonal Trust in Different Social Scenarios: Evidence from the Social Mindfulness Paradigm. Sleep deprivation (SD) is widely recognized for its negative impact on both cognitive abilities and social interactions. Nonetheless, the effect of sleep deprivation on interpersonal trust in social scenarios is poorly understood. These findings suggest that SD selectively impacts interpersonal trust, and this effect is not influenced by simple cognitive functions such as alertness.
Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea–Hypopnea Syndrome. Obstructive sleep apnea–hypopnea syndrome (OSAHS) affects over 936 million adults globally. Recently, it has been found to contribute to gait disorders, but there is limited information regarding how various indicators of OSAHS affect gait patterns. Subjects with elevated AHI exhibited increased step width and decreased stride length in comparison to those with lower AHI. The nm (no or mild)-hypoxemia group demonstrated faster stride frequency than the ms (moderate to severe)-hypoxemia group.
Impact of 30-minute and 90-minute Naps on Aerobic and Anaerobic Intermittent Performance in Collegiate Soccer Players. Napping effectively enhances the aerobic and anaerobic performance of collegiate soccer players following a normal night of sleep. Implementing strategic napping may be beneficial for athletes seeking to optimize their performance before training or competition. No notable differences between the N30 and N90 groups.
We are the Sensors of Consciousness! A Review and Analysis on How Awakenings During Sleep Influence Dream Recall. Since the 1930s, researchers have awakened people from different stages of sleep to record what they have experienced. While some aspects, including asking whether participants had dreams or thoughts before awakening, largely remain the same, others, such as the method of awakening, vary greatly. Both the awakening procedure and participant characteristics influence the amount of reported sleep experiences, which can impact study outcomes, such as the identification of neural correlates of consciousness.
TEX10: A Novel Drug Target and Potential Therapeutic Direction for Sleep Apnea Syndrome. Sleep apnea syndrome (SAS) is a prevalent sleep disorder strongly associated with obesity, metabolic dysregulation, and cardiovascular diseases. While its underlying pathophysiological mechanisms remain incompletely understood, genetic factors likely play a pivotal role in SAS pathogenesis. Our study identified multiple potential therapeutic targets causally linked to SAS, with TEX10 emerging as a key candidate gene.
