SUBJ: Turning down the outrage: People feel threatened
SUBtitle: Exercise reduces Alzheimer’s progression
Let food be thy medicine and medicine be thy health -Hippocrates
To love another person is to see the face of God-Jean Val Jean, Les Miserables
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SHORT NOTES
1..Turning down the outrage: a framework for bridging divides. people are so angry because They feel threatened.
2..Higher levels of physical activity were associated with lower levels of Alzheimer progression.
3..Parkinson disease pathology can originate in the kidney.
4..Air pollution is the second leading cause of death worldwide.
5..Cause of long COVID. inflammation from damaged Peroxisomes (organelles involves in oxidative reactions and metabolism).
6..#1 exercise for balance: stand with a hand on a chair, lift the opposite leg to the level of your hip.
7..Luteolin as a medicine with an anti-graying effect on hair in humans.
8..Certified supplements: Find which supplements you may be able to trust.
9..Huge Diet Study: More Butter, a higher mortality risk.
10..“Potential goldmine” for new antibiotics in combating resistant bacteria.
11..Reducing side-effects of skin problems from cancer therapy.
12..A method found to recycle methacrylate plastics to restore original monomer.
13..The results provide insights into Parkinson’s pathogenesis and identify a potential therapeutic target.
14..A new AI tool at a materials-developing company greatly increased success.
LONG NOTES
Science 28 Feb pg 933: Turning down the outrage: A moral psychologist offers a framework for bridging divides. Kurt Gray uses stories and science to help readers understand why people are so angry at each other about almost everything. The reason, in his view? They feel threatened. They are afraid of what the future holds for them and for those they love. They feel as though the things that might ease their daily struggles are being ignored or even mocked by “the other side.” Three myths: The first myth is that humans evolved as predators rather than prey. The second myth Gray seeks to dispute is that harmless wrongs exist. Here, he outlines much of his research program and makes his second major point: that all moral understanding is implicitly rooted in variable perceptions of harm. Gray calls “moral typecasting.” According to this framework, we and those on “our side” are innocent victims, pursued by attackers who want to destroy us and the things we value. However, neither of these things are usually true. a third and final myth: that factbased arguments can bridge moral divides. Facts might make us seem rational, he concedes, but it is our stories of vulnerability that help heal divisions, and sharing them can open the door to finding common ground.
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition: In this cross-sectional study of 1144 participants, including individuals with and without cognitive impairment, higher levels of PA were significantly associated with lower levels of plasma neurofilament light chain and phosphorylated tau-217 and better cognition. These associations were more pronounced in the cognitively impaired group and the group aged 65 years and older compared with the cognitively unimpaired and younger groups.
Parkinson disease pathology can originate in the kidney. In conclusion, our results suggest that the general CKD population may not exhibit a greater propensity for PD than their non-CKD counterparts. However, this might be contingent upon specific lifestyle and comorbid conditions. Thus, certain lifestyle alterations could be crucial in mitigating the potential manifestation of PD in patients diagnosed with CKD.
Science Mar 3: pg 1019: Is the air we breathe safe? Air pollution is the second leading cause of death worldwide.The air quality index does not accurately convey the toxins in urban fires like Los Angeles. Activated carbon filters are useful for indoor air circulation; pg 1039: Lung inflammation drives long COVID. Peroxisomes (organelles involves in oxidative reactions and metabolism) are damaged and result in impaired regeneration of lung tissue after COVID. Getting enough vitamin C (Mito-C twice a day) and vitamin D (dosing for COVID) are important to prevent long COVID. pg 1051: Fish have been engineered to remove harmful methylmercury from water and convert it to elemental mercury, which is much safer.
AARP: #1 exercise for balance: stand with a hand on a chair, lift the opposite leg to the level of your hip.
Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice. These results are encouraging for the practical application of luteolin as a medicine with an anti-graying effect on hair in humans.
Certified supplements: Given that so many supplements, about 50%, do not contain the ingredients stated on the label, I am starting a certified supplements page on my website so you can see which supplements you may be able to trust. See certified!
From RR, Oregon”Huge Diet Study: More Butter, More Problems— Survival benefit was tied to plant-based oils, including affordable alternatives to olive oil” MedPage Today, March 6, 2025 “Key Takeaways- A higher intake of butter was tied to a higher mortality risk in a large study; A higher intake of plant-based oil was linked with a lower mortality risk. Plant oils associated with survival benefit were olive, soybean, and canola oils.
“Potential goldmine” for new antibiotics. (TY Hazel) A discovery by Weizmann scientists has astounded the world of microbiology (and the BBC). Every cell in the human body makes bacteria-killing chemicals to recycle proteins. These natural antibiotics could transform future research into combating resistant bacteria.
Reducing side-effects of cancer therapy. (TY Atid-EDI) Israel’s Lutris is developing a topical B-Raf Inhibitor LUT014 – a proprietary, first-in-class, small molecule allowing administration of EGFR (Epidermal Growth Factor Receptor) Inhibitors to cancer patients without interruptions caused by skin problems.
Science 21 Feb pg 837-method found to recycle methacrylate plastics to restore original monomer for reuse; Science p. 892, One of the major causes of neurodegeneration in patients with Parkinson’s disease (PD) is the intracellular accumulation of α-synuclein in neurons. Wu et al. investigated the mechanisms mediating the uptake of α-synuclein in neurons using in vitro and in vivo models. The product of the recently identified PD-risk gene FAM171A2 was found to be the neuronal receptor for α-synuclein fibrils, mediating their internalization through endocytosis. In silico screening identified an approved drug, bemcentinib, that is able to inhibit α-synuclein internalization in vitro and in vivo by blocking its binding to FAM171A2. The results provide insights into PD pathogenesis and identify a potential therapeutic target.
AI benefits: Economist Mar 8 pg 74: A new AI tool at a materials-developing company results in a 44% increase in number of materials discovered, a 17% increase in product prototypes, and a 39% increase in patents filed.
