KIDNEY DISEASE
From Sheri: I had stage 3 kidney disease and happy to share what my acupuncturist gave me …doctors don’t even bring it up on my chart anymore. Woohoo!Sheri Novak..herbs: dong quai..and Adtragulus root. From California shelves
How to avoid Kidney stone disease (KSD) (alternatively nephrolithiasis or urolithiasis), a global health care problem. Low urine output and dehydration are the common risks of all stone types, whereas hypercalciuria, hyperoxaluria, and hypocitraturia are the major risks of calcium stones. Lots more details how to avoid stones.
Weekend sleep duration is linked to health issues, including mortality. The underlying mediators of long weekend sleep duration (lWD) and chronic kidney disease (CKD) could be the dysregulation of human behaviors, metabolism, or biological functions. Longer weekend sleep duration was linked to a decrease in eGFR levels, which may indicate that your kidneys aren’t working properly..
Insulin resistance leads not only to diabetes but also kidney failure.
Science 12/15 pg 1213-Breakthrough of the Year-Wegovy/semaglutide! Causes weight loss by weekly injection, and reduces the risk for heart disease, diabetes, stroke, and kidney disease.
New treatment for chronic kidney disease. Nephrospec. It uses an acoustic wave treatment called eHAT to treat chronic kidney disease (CKD) by promoting new blood vessel formation and restoring damaged tissue function.
WebMD-kidney health-limit meds like ibuprofen and naproxen, antibiotics, herbal supplements, salt, fat, sugar, alcohol, cigarettes, drink lots of water, exercise, get tested.
Sci 14 Apr pg 169- Taking supplemental NAD+ (and probably niacin) reduces damage to kidneys from infections, drugs, and toxins. It also promotes recovery of the kidneys.
Preventing kidney failure. Israel is the first country in the world to ban treatments with glyoxylic acid, a common ingredient in hair-straightening products. Scientists at Israel’s Shaare Zedek Medical Center showed that the chemical is absorbed by the skin, often causing pain, vomiting and acute kidney injury.
Israelis liberDI has received clearance from the US FDA for its Digital Dialysis Clinic. The 3kg device allows patients to perform a 90 min dialysis at home or at work, by themselves, monitored by their physician using the advanced telemedicine capabilities of the system.
Benefits of dietary fiber extend far beyond the intestines. Increased dietary fiber (DF) intake elicits a wide range of physiologic effects, not just locally in the gut, but systemically. These gut-associated changes can then alter the physiology and biochemistry of the body’s other main nutrient management and detoxification organs, the liver and kidneys. The molecular mechanisms by which DF alters the physiology of the gut, liver, and kidneys is likely through gut-localized events (i.e., bacterial nitrogen metabolism, microbe-microbe, and microbe–host cell interactions) coupled with specific factors that emanate from the gut in response to DF, which signal to or affect the physiology of the liver and kidneys.
JN 3/23 Serum 25(OH)D concentrations, time spent outdoors, and dietary vitamin D intake were all inversely associated with new-onset acute kidney injury, independent of genetic risks for kidney diseases.
Even doses of 10 g/day in adults have not been reported to cause harm in confirmed scientific studies. The Food and Nutrition Board (2000) of the Institute of Medicine raised the RDA for AA for men and women to 90 and 75 mg resp., with an Upper Limit (UL) for safety established at 2 g per day. The UL was based on osmotic diarrhea and gastrointestinal disturbances. The Panel on dietary antioxidants and related compounds stated that the in vivo data do not clearly show a relationship between excess ascorbic acid intake and kidney stone formation, pro-oxidant effects, or excess iron absorption (Naidu 2003).
Biogerontology. Volume 23, Issue 6 As the kidneys age, gradual changes in the structures and functions of mitochondria occur. Dietary restriction (DR) can play a protective role in ageing-associated renal decline. To conclude, impaired mitochondria, increased oxidative stress, and severe fibrosis were noticed in the aged kidneys, and DR improved these changes by increasing functional mitochondria and promoting autophagic clearance.
Caffeine intake lowers risk of kidney stones by about 30% – and 500mg of vitamin C twice a day lowers it about 22% more – The analysis included 217,883 participants; participants in the highest quintile of caffeine intake had a 26% lower risk of developing stones in the HPFS cohort, a 29% lower risk in the NHS I cohort, and a 31% lower risk in the NHS II cohort. Caffeine intake is independently associated with a lower risk of incident kidney stones.
The combination of Dasatinib (5 mg/kg) and Fisetin (100mg/kg) was effective to remove senescent cells as determined by skin biopsy. For three days in a Mayo Clinic clinical trial, the nine human participants received a combination dose of dasatinab and quercetin. Though the drugs cleared the body in a couple of days, effects on reducing senescent cells were evident for at least 11 days. The researchers say this shows the senolytic drug combination significantly decreases senescent cell burden in humans. Senescent cells are characteristic in end-stage kidney failure as well as diabetes-related kidney disease. By removing the cells from mice, researchers had previously found that senolytics alleviate insulin resistance, cell dysfunction, and other processes that cause disease progression and complications.
Low carb pros and cons – Taste buds are satisfied by rich sumptuous foods, which doesn’t prevent losing weight (for a while), but high protein favors forming kidney stones).
The effect of taking vitamin C supplementation on kidney stones. the study of Stampfer (4) has shown that those taking elevated doses of vitamin C in fact have a 22% lower incidence of kidney stones.
WedMD-conditions that harm kidneys-Anorexia Nervosa, High Blood Pressure, High Cholesterol,
nonsteroidal anti-inflammatory drugs (NSAIDs) — which include ibuprofen (Advil) and naproxen (Aleve) — can raise bleeding risks in the gastrointestinal tract, damage the kidneys and raise blood pressure.
AARP: In fact, “a mega amount” of calcium can cause harm, Chan says. Some studies suggest that taking a supplement with an excessive amount of calcium can be dangerous for middle-age and older adults, with negative effects on the kidney, heart and prostate.
Volume 11, Issue 4, July 2020 The prevalence of chronic kidney disease (CKD) is increasing and dietary interventions may be a strategy to reduce this burden. In the general population, higher potassium intake is considered protective for cardiovascular health. Due to the risk of hyperkalemia in CKD, limiting potassium intake is often recommended. However, given that poor cardiovascular function can cause kidney damage, following a low-potassium diet may be deleterious for patients with CKD.
drink more water
Supplementing with niacin (vitamin B3) has numerous major benefits. Adipose tissue reduces reduces prediabetes effects in fat, the brain improves reducing Alzheimer’s risk, the pancreas improves insulin regulation, the vasculature reduces blood pressure, the kidneys, skeletal muscle, heart, and the immune system improve.
A successful treatment for sepsis using iv vitamin C. The global burden of sepsis is estimated as 15 to 19 million cases annually with a mortality rate approaching 60% in low income countries. Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine may prove to be effective in preventing progressive organ dysfunction including acute kidney injury and reducing the mortality of patients with severe sepsis and septic shock.
Moderate consumption of coffee and tea (6 cups/day) does not harm kidneys. Low to moderate coffee consumption is not expected to be a concern for kidney health in the general population.
Phosphate intake (like soda pop) is killing you slowly – Numerous studies have consistently found significant, independent associations between increased serum phosphate concentrations and greater cardiovascular events and mortality. These relations have been shown in people with chronic kidney disease but also in the general population.
Benefits of dietary fiber extend far beyond the intestines. Increased dietary fiber (DF) intake elicits a wide range of physiologic effects, not just locally in the gut, but systemically. These gut-associated changes can then alter the physiology and biochemistry of the body’s other main nutrient management and detoxification organs, the liver and kidneys. The molecular mechanisms by which DF alters the physiology of the gut, liver, and kidneys is likely through gut-localized events (i.e., bacterial nitrogen metabolism, microbe-microbe, and microbe–host cell interactions) coupled with specific factors that emanate from the gut in response to DF, which signal to or affect the physiology of the liver and kidneys.
Longevity-linked ratios in burritos are then shown to predict surprisingly low rates of Alzheimer’s, cancer, heart disease, stroke and other age-associated illnesses within Hispanic-Americans aged 80 and above, and the partial reversal of advanced kidney disease when cats are fed a specially-formulated kidney-support diet.
Science 5 Feb 2016 Pg 679 – Potassium loss stresses out kidney cells, esp. in African-Americans, who are 5x more likely to develop advanced kidney disease.
Dr. Odden – For CV risk in elderly, the main challenge is to get exercise to prevent frailty and sacropenia (muscle wasting). From 1930 to 2010, lifespan has increased 2.5 yr every 10 yrs = 25%. At age 65, systolic blood pressure (BP) = 130 is ideal, and at age 86 systolic BP = 180 is good. From 65-74, healthy BP (not too high or low), low LDL, good insulin sensitivity are healthy. From 75-84, only BP is a risk factor. Age 85+, none of these matter anymore to survival rate. The new risk factors for healthy aging are inflammation (CRP level), kidney function, and cardiac stiffness (from too much calcium). These 3 represent lifetime risk accumulation. Note there is a harm of lowering BP beyond age 65.
Protein, calcium, vitamin D, and exercise build and maintain muscle mass, bone density, and kidney function – Achieving a “peak lean body mass” with particular emphasis on muscle and bone mass has become a priority. Current evidence points to the importance of consuming a sufficient amount of dietary protein, calcium, and vitamin D in combination with physical training to build up and maintain strong bones and muscles to reach high peak mass and strength in adulthood. the PROT-AGE study group recommends average daily intakes at least in the range of 1.0–1.2 g protein/kg body weight per day, and those who have acute or chronic diseases need even more dietary protein.
Vitamin C and antioxidants reduce arterial stiffness reducing risk of many pathologies – (so take 500mg vitamin C twice a day) Arterial stiffening is a hallmark of aging and is closely associated with many pathologic conditions, including atherosclerosis, dyslipidemia, diabetes, and chronic kidney diseases.
Science 343:580 African Americans have a three to five times greater risk of developing end-stage kidney disease and twice the risk of dying from heart disease than do individuals of European descent. In addition to socioeconomic factors, genetic factors probably contribute to these differences.
Much of our understanding about the potential risks associated with high phosphorus intake comes from the clinical experience with chronic kidney disease (CKD)4 patients in whom high serum phosphate concentration has been shown to be significantly associated with cardiovascular and all-cause mortality
You are what your [grand]mother ate! Evidence that early nutrition, stress, and other similar environmental exposures can have lingering impacts on later health outcomes has now been widely documented in human populations. Early proposals focused on growth alterations or changes in the function of organs such as the kidneys or liver, which it was speculated would be short-changed under conditions of fetal nutritional stress. More recent work has consolidated around identifying epigenetic changes induced by prenatal or maternal experiences. Epigenetic modifications typically involve chemical changes to the chromatin that influence which genes can be expressed, silencing or amplifying gene production in a targeted fashion.
High fat diet (like Atkins) leads to kidney disease – Although a number of experimental animal models have suggested that hyperlipidemia is associated with progressive kidney failure. Conclusion: Higher saturated fat intake is significantly associated with the presence of high albuminuria.
The majority of adults do not get enough magnesium. Few multivitamin/minerals contain more than 100 mg of magnesium. As elderly have lower kidney function, they should avoid taking more than 350mg daily.
