SUBJ: Tattoos increase cancer risk 21%
SUBtitle: Two colas a day may shorten your lifespan
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Student research poster: Two colas a day may shorten your lifespan.
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SHORT NOTES:
Compared with nontattooed individuals, Swedish people with tattoos showed a 21% greater risk of malignant lymphoma, diffuse large B-cell lymphoma, and follicular lymphoma.
Older people are less adventurous.
Senescent cells have many valuable functions for tumor suppression, wound healing,etc. and should not be eliminated.
Senescent cells progressively lose their homeostatic function.
Daniel Dennett, who merged philosophical thinking with scientific evidence from many fields, died.
Besides the lipid-lowering effect, statins have been suggested to inhibit the development of cardiovascular disease.
Many risk factors, including cholesterol, hypertension, sex, lack of exercise, insufficient sleep, and genetics aggravate atherosclerosis.
TERT activation targets DNA methylation and multiple aging hallmarks.
There is a central place to quickly find links to many relevant papers & data regarding the evidence-based science of healthy aging. Healthy aging Ornish Intensive Lifestyle changes Human aging biology of aging age-related physiological changes diseases of old age.
Detecting some of the 400,000 diagnosed with oropharyngeal cancer with saliva test.
We will investigate how certain gut bacteria affect human behavior, such as anxiety and stress.
LONG NOTES:
Science 21 June: Pg 1313-The risk of ink- Tattoos have exploded in popularity across Europe and the US in recent decades despite possible health risks tied to carcinogenic chemicals in the ink. Nielsen et al. ran a correlational study using data between 2007 and 2017 from the Swedish National Cancer Register to investigate the potential health risks of tattooing. Compared with nontattooed individuals, Swedish people with tattoos showed a 21% greater risk of malignant lymphoma, diffuse large B-cell lymphoma, and follicular lymphoma.
Older people are less adventurous: The authors found that older age was associated with an exploitation bias and lower microstructural integrity of the locus coeruleus. Larger stores of prior knowledge, declining cognitive control, and a focus on close social bonds converge in later life. This combination creates a tendency to exploit options with known rewards while avoiding the ambiguity and risk associated with exploration.
pg 1300- GRG recent perspective on the beneficial functions of senescent cells may be of interest to the group. The bigger issue is that I think targeting senescent cells safely and effectively for therapeutic purposes will be much more complicated than many have anticipated. –Functions of senescent cells-They have many valuable functions for tumor suppression, wound healing,etc. and should not be eliminated. “Although several studies in mouse models support the hypothesis that senescent cells can trigger or contribute to age-associated phenotypes, more recent studies have revealed additional roles for senescent cells in nonharmful and even physiological processes. Indeed, eliminating senescent cells in mice can be detrimental to health, highlighting the importance of these cells in mammalian homeostasis and physiology.”
Senescent cells progressively lose their homeostatic function, secrete a variety of inflammatory factors, and exhibit persistent pro-inflammatory signaling, which elicits vascular and systemic inflammatory responses (13). In this regard, immune cells residing in atherosclerotic plaques, including monocytes and macrophages, display increased indices of cellular senescence. Eliminating these senescent cells with immunotherapies targeting “senoantigens”—peptides specifically expressed on senescent cells—or using small molecules known as “senolytics,” therefore represent new therapeutic avenues to reduce inflammation and atheroma formation.
Pg 1305 – Daniel Dennett died at age 82. Daniel Clement Dennett, who merged philosophical thinking with scientific evidence from many fields, died on 19 April at age 82. In the central question of the nature of the mind, Dennett took a neuroscience-anchored position, arguing that consciousness and all higher cognitive abilities could be understood as a direct consequence of the physiology of the brain. He expanded his ideas in best-selling books about religion and evolution and became one of the strongest voices publicly defending atheism and Darwinism.
Statins do more than lower cholesterol. A friend reported Crestor is the preferred statin with fewer side effects.
1) Besides the lipid-lowering effect, statins have been suggested to inhibit the development of cardiovascular disease through anti-inflammatory, antioxidant, vascular endothelial function-improving, plaque-stabilizing, and platelet aggregation-inhibiting effects. The preventive effect of statins on atherothrombotic stroke has been well established, but statins can influence other cerebrovascular diseases. This suggests that statins have many neuroprotective effects in addition to lowering cholesterol.
2) Statins don’t just lower cholesterol levels but also reduce the risk of fatty plaques breaking off from walls of your arteries, reducing the risk of heart attack and stroke.
Science – Many risk factors, including cholesterol, hypertension, sex, lack of exercise, insufficient sleep, and genetics aggravate atherosclerosis (7, 8). However, age is the strongest driver; the risk of major cardiovascular events doubles every decade of life. While age may be so strongly associated because time allows many of the typical risk factors to take root and inflict tissue damage, our insight on how the immune system changes with age is an opportunity for intervention. In contrast to many aspects of aging, an aging immune system is in theory druggable, raising the intriguing possibility that the system’s aging can be halted or reversed. Two phenomena concerning immune cell production (hematopoiesis) and immune cell wasting (senescence) offer clues to possible paths forward.
[study]: “TERT activation targets DNA methylation and multiple aginghallmarks”. Highlights:
• TERT has been linked directly or indirectly to all hallmarks of
aging
• TERT gene is epigenetically repressed with onset of aging markers
in all tissues
• TERT activator compound (TAC) restores TERT levels to promote telomere maintenance and reprogram gene expression
• TAC in aged mice reduces senescence/inflammation and increases
neurogenesis/cognition
There is a central place to quickly find links to many relevant papers & data regarding the evidence-based science of healthy aging. Aaushi eReference aims to promote new ideas and enhance research into improving the lives of older patients through healthy aging and improving patient outcomes in diseases of aging. A focus on healthy aging provides a means of organizing evidence of various components of healthy aging in the contexts of human aging, the biology of aging, age-related physiological changes and diseases of old age. One fundamental component of healthy aging is maintenance of cognitive function.The Ornish Intensive Lifestyle changes improve cognition in patients with mild cognitive impairment or early dementia in a small trial. The study identified four components of healthy aging, including a healthy diet, exercise, stress management and social support. The Aaushi eReference entry for healthy aging expands upon the components of healthy aging integrating with human aging, the biology of aging, age-related physiological changes, and diseases of old age.
Healthy aging < https://aaushi.info/A8778 >
Ornish Intensive Lifestyle changes < https://aaushi.info/A58764 >
Human aging < https://aaushi.info/A24394 >
biology of aging < https://aaushi.info/A8989 >
age-related physiological changes < https://aaushi.info/A9575 >
diseases of old age < https://aaushi.info/A50995 >
Detecting cancer with saliva test. Israel’s Salignostics (see here previously) is working with Israel’s Sheba Medical Center to develop a saliva test for the early detection of oral cavity cancer. It may save some of the 400,000 diagnosed with oropharyngeal cancer, of whom only 50% will survive five years after diagnosis.
The French-based Human Frontier Science Program (HFSP) funds basic research in life sciences. It has awarded a $1.2 million grant to Ben Gurion University Prof Michael Meijler to investigate how certain gut bacteria affect human behavior, such as anxiety and stress.
