(8/28/2024) A nutrition expert/colleague has suggested that there is conflicting evidence about fatty15, which means my enthusiasm may be incorrect.  Below are a number of citations he sent.  But this statement indicates C15 may help with weight control:

“skim and 1% milk were associated with weight gain, but dairy fat was not.”

–This particularly rigorous study caught my eye. It discusses the complexity of such studies.
“Results between total milk at age 10 y and percent body fat at age 11 y were attenuated after accounting for dietary reporting errors, suggesting that this may have been a spurious finding that was attenuated after accounting for individuals with implausible dietary intakes. Findings from the majority of our longitudinal models support findings from other studies that showed no relation between milk intakes and adiposity in children after adjusting for confounding factors such as age, sex, sedentary behaviors, sociodemographic variables, total energy, and consumption of nondairy beverages.”
Source:  The Journal of Nutrition, Volume 141, Issue 11, November 2011, Pages 2035-2041, “Milk Intakes Are Not Associated with Percent Body Fat in Children from Ages 10 to 13 Years” Noel Sabrina E. et al.
–“Only nine of the ninety-four studies found a positive association between milk and other dairy products and body fatness.” “In conclusion, there is little evidence to support a concern to limit the consumption of milk and other dairy products for children on the grounds that they may promote obesity.”
Source: Nutrition Research Reviews, 27 November 2018, Anestis Dougkas et al.
–“Children who drank the most milk gained more weight, but the added calories appeared responsible. Contrary to our hypotheses, dietary calcium and skim and 1% milk were associated with weight gain, but dairy fat was not. Drinking large amounts of milk may provide excess energy to some children.”
“Also found in dairy products is the hormone estrone, which may promote increases in body weight. Furthermore, whey protein is often added during processing to reduced-fat milk, estrone is found in whey, and whey protein itself may promote weight gain.”
Source:  Arch Pediatr Adolesc Med. 2005;159(6):543-550
–“… it has been thought that increased consumption of dairy products has an association with an increase in blood plasma OCS-FAs. However, there is currently no direct evidence but rather a casual association through epidemiology studies. Furthermore, a number of studies on cardiometabolic diseases have shown that plasma concentrations of OCS-FAs are associated with lower disease risk, although the mechanism responsible for this is debated. One possible mechanism for the endogenous production of OCS-FAs is α-oxidation, involving the activation, then hydroxylation of the α-carbon, followed by the removal of the terminal carboxyl group. Differentiation human adipocytes showed a distinct increase in the concentration of OCS-FAs, which was possibly caused through α-oxidation. Further evidence for an endogenous pathway, is in human plasma, where the ratio of C15:0 to C17:0 is approximately 1:2 which is contradictory to the expected levels of C15:0 to C17:0 roughly 2:1 as detected in dairy fat. We review the literature on the dietary consumption of OCS-FAs and their potential endogenous metabolism.”
Source:  Jenkins et al., Molecules 2015, 20(2), 2425-2444

 

(12/30/2023) Pentadecanoic acid, marketed as a supplement fatty15, is ASTOUNDING.  Please read this article.  Over the past 40 years, diets with lower saturated fats have been recommended to decrease cholesterol levels and subsequent risks of heart disease1. In the U.S., during the 20-year period following this initial recommendation, the average individual’s daily intake of whole fat milk was reduced more than 4-fold, from 283 to 65 grams per day, in an effort to lower dietary saturated fats2,3. Despite this drop in whole fat milk intake, the global prevalence of obesity, type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease has increased4,5,6. Further, an 18-year longitudinal study including over 25,000 individuals demonstrated that children fed whole fat milk had a lower risk of having obesity compared to children who were provided fat-free or 1% fat milk, and multiple studies have demonstrated associations between higher dietary intake of full-fat dairy and reduced risk of type 2 diabetes and cardiovascular disease7,8,9. As such, there is a need re-evaluate potential health risks versus benefits of dietary dairy fats. IT TURNS OUT THE DIFFERENCE IS WHOLE MILK HAS PENTADECANOIC ACID.

I have just ordered a 90 day supply of this supplement, the only place I believe it is available.  90 days costs about $120.  But it is much cheaper than metformin or rapamycin, safer, but with the same health effects.  Order at fatty15.com/ALFREDORDMAN

In rats, an effective oral dosage is 5mg/kg, and much higher doses were absolutely safe.  As people weight 60-80 kg, a dosage of 400 mg per day would be valid.

From GRG: Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds

I’ve been taking a supplement called “fatty15” for about 2 years now, before I was aware of potential longevity benefits. A new paper claims that its longevity benefits may be on par with rapamycin and metformin.  Those 2 medications require a prescription.  But pentadecanoic acid is a supplement.