SUBJ: Booklet sent this week
SUBtitle: Cannabidiol (CBD) has many benefits.
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SHORT NOTES:
Cannabidiol (CBD) has many benefits.
There is a growing body of research reporting changes to the composition and metabolites in the microbiomes of Alzheimer’s patients [2]. (Consider BHB supplement).
“SAFE AND PROVEN, Steps to a Healthy Lifespan,” sent free to paid subscribers this week. It can be purchased by sending $5 to ordman@beloit.edu through PayPal.
Heart Failure or Therapy Failure? Toxins Cause Cardiomyopathy – Heart muscle cells do not just fail and “wear out” for no reason.
“Reversal of biological age in multiple rat organs by young porcine plasma fraction”
Aripiprazole, a Novel Option in the Management of Restless Legs Syndrome (RLS)
Overall Obesity Not Abdominal Obesity Has a Causal Relationship with Obstructive Sleep Apnea in Individual Level Data.
Recent binge drinking showed significant associations with epigenetic age acceleration.
Obesity is a known comorbidity in numerous chronic conditions, including cardiovascular diseases, metabolic disorders, dementia, and cancers: But one meta-analysis found that 35% of obese people display a phenotype referred to as metabolically healthy obesity (MHO) [2].
The blood-brain barrier (BBB) leaks with aging, causing inflammation and cognitive impairment [1]. (Key message-keep mitochondria healthy with exercise, supplements, low stress)
Longevity has become an industry, a subject of bestsellers, podcasts and newsletters. But is a life meted out in metrics, often for a price, worth it?
Higher Levels of Vitamins Associated with Lower Risk of Mortality Among Diabetics
LONG NOTES:
Cannabidiol (CBD) has many benefits. It upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines. In this study, for the first time, we showed the evidence suggesting that the VDR plays a critical and multifaceted role in various types of human cells.
Heart Failure or Therapy Failure? Toxins Cause Cardiomyopathy – Heart muscle cells do not just fail and “wear out” for no reason. When oxidative stress increases inside the heart tissue, inflammation by definition then exists as well. Also, part of that increased oxidative stress is the result of decreased ATP (adenosine triphosphate) production in the mitochondria of the heart cellS. (Thus the value of many supplements I take to maintain the mitochondria and ATP production.)
There is a growing body of research reporting changes to the composition and metabolites in the microbiomes of Alzheimer’s patients [2]. Studies have also linked the microbiota-gut-brain axis to the origins of neurodegenerative disorders [3]. Their results indicated that markers of systemic and intestinal inflammation were elevated in Alzheimer’s patients. They observed decreased levels of healthy aging-associated microbes that produce the short-chain fatty acid butyrate. (Consider BHB supplement).
“Reversal of biological age in multiple rat organs by young porcine plasma fraction” Overall, this study demonstrates that a young porcine plasma-derived treatment markedly reverses aging in rats according to epigenetic clocks, IgG glycans, and other biomarkers of aging.
Aripiprazole, a Novel Option in the Management of Restless Legs Syndrome (RLS) Patients with Augmentation and/or Severe RLS Symptoms: A Report of 4 Cases. All four patients with severe RLS and augmentation with dopamine agonists achieved symptom control with aripiprazole. Patients endorsed 90– 100% efficacy with aripiprazole by subjective self-report after failures with other agents.
Overall Obesity Not Abdominal Obesity Has a Causal Relationship with Obstructive Sleep Apnea in Individual Level Data. Compared to abdominal obesity, overall obesity showed a causal relationship with OSA and its quantitative traits, especially in men.
Recent binge drinking showed significant associations with epigenetic age acceleration. Middle-aged participants who reported recent binge drinking (defined as women consuming over 4 drinks per day, men consuming over 5 drinks per day, or less than 2 alcohol-free days per week) had a 0.56-year increase and a 0.93-year increase in epigenetic age acceleration according to GrimAge and PhenoAge, respectively. A recent study showed that stress can cause a transient increase in epigenetic age [5].
Metabolically unhealthy obesity (MUO), metabolically healthy normal weight (MHNW), and metabolically unhealthy normal weight (MUNW). Obesity is a known comorbidity in numerous chronic conditions, including age-related ones. It has been shown to positively correlate with cardiovascular diseases, metabolic disorders, dementia, and cancers: basically, all the major killers. However, this increase in risk does not affect every individual. Some obese people are perfectly metabolically healthy, just as many lean people are metabolically unhealthy. One meta-analysis found that 35% of obese people display a phenotype referred to as metabolically healthy obesity (MHO) [2]. One study found no increased risk of cardiovascular diseases in people with MHO compared to healthy lean people [3]. Another study reported largely similar results for CVD and diabetes [4]. However, other recent studies reached the opposite conclusion [5]. During the follow-up period, 903 cases of diabetes onset were identified. In the unadjusted model, the risk of diabetes compared to metabolically healthy people with normal weight was 1.7 times higher for MHO, 2.5 times higher for MUNW, and 3.6 times higher for MUO.
In the brain, the microvessels (MVs) that are responsible for carrying blood to neurons and other cells provide careful filtration, both from infectious diseases and toxins. This is the blood-brain barrier (BBB), and it leaks with aging, causing inflammation and cognitive impairment [1]. These researchers have done prior work on this topic. They have found that, as mitochondrial dysfunction and the loss of proteostasis take hold, the MV begins to deteriorate and so the BBB begins to leak [2]. (Key message-keep mitochondria healthy with exercise, supplements, low stress)
Longevity has become an industry, a subject of bestsellers, podcasts and newsletters. But is a life meted out in metrics, often for a price, worth it?
Higher Levels of Vitamins Associated with Lower Risk of Mortality Among Diabetics During Median 13.7 Years of Follow-Up. Getting enough vitamins is critical for diabetics, suggests a Frontiers in Endocrinology study published on September 19, 2023. While individual vitamins had different effects on the risk of all-cause mortality in patients with diabetes, high-level co-exposure to multiple vitamins significantly reduced the risk of all-cause mortality in patients with diabetes, with differences observed among genders, ages, and race. This suggests that when developing vitamin intervention strategies for patients with diabetes, consideration should be given not only to the dosage of individual vitamins but also to the variations between different population groups.
