SUBJ: metformin shortens lifespan after 10 years of use
SUBtitle: Vitamin D concentrations were inversely associated with risk of heart disease
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SHORT NOTES:
type 2 diabetes patients treated with metformin had shorter survival time than matched controls; Vitamin D concentrations were inversely associated with risk of heart disease; fat-free mass loss was not a significant predictor of weight regain at 1 y in individuals with obesity; Healthy young adults who adopt an Healthy U.S.-Style Dietary Pattern [HDP] that may be vegetarian or omnivorous, including lean red meat, experience short-term changes with improvements in multiple lipid-related cardiovascular risk factors; Vitamin D deficiency is common in pregnancy; Genistein is used to restore or improve memory functions in different animal models and humans; MedDiet can have anti-inflammatory effects; How Tired is Too Tired to Drive?; How to Live Past 120; Good list of nutritional, supplemental and physical activity actions that can promote healthy longevity by affecting epigenetics; Another study on the value of melatonin for healthy longevity; ChatGPT, an AI-based language model, was able to predict Alzheimer’s in 80% of cases when analyzing speech; potential of rapamycin to slow down skin senescence when applied topically as a cream; Will AI Change Health Care? The short answer is: “You betcha”; for a week after exercise injury, 10,000IU vitamin A, bromelin (pineapple juice), capsaicin, turmeric, vitamin E, garlic (2-4cloves), ginger, fish oil, resveratrol, SAMe, zinc.
LONG NOTES:
New paper on Metformin. Questionable long term effects shown. Using the full twenty-year period, we found that type 2 diabetes patients treated with metformin had shorter survival time than matched controls, as did sulphonylurea patients.
Serum 25(OH)D concentrations were inversely associated with risk of CHD (P < 0.01).
J Nutr May – % fat-free mass loss (FFML) was not a significant predictor of weight regain at 1 y in individuals with obesity. However, a greater %FFML was accompanied by a greater increase in ghrelin secretion under ketogenic conditions, suggesting a link between fat-free mass and appetite regulation.
Healthy young adults who adopt an Healthy U.S.-Style Dietary Pattern [HDP] that may be vegetarian or omnivorous, including lean red meat, experience short-term changes in gut microbial composition, which associate with improvements in multiple lipid-related cardiovascular risk factors.
Vitamin D deficiency is common in pregnancy. Vitamin D plays an important role in the developing brain, and deficiency may impair childhood behavioral development. This study confirmed a high prevalence of vitamin D deficiency in pregnancy, particularly among Black women, and revealed evidence of an association between lower gestational 25(OH)D and childhood behavioral problems. Associations were more apparent in analyses restricted to prenatal rather than cord blood samples. Interventions to correct vitamin D deficiency during pregnancy should be explored as a strategy to improve childhood behavioral outcomes.
Due to the neuroprotective, anti-oxidative and anti-inflammatory properties, Genistein (GEN) is used to restore or improve memory functions in different animal models and humans. [I take GEN daily.] GEN is a non-steroidal phytoestrogen that belongs to the isoflavone class. It is abundantly found in soy. Soy and its products are used as food components in many countries including India. The present review is focused to address roles of GEN in brain functions in the context of learning and memory as a function of aging and
neurological disorders. Memory decline is one of the most disabling features observed during normal aging and age-associated neurodegenerative disorders namely Alzheimer’s disease (AD) and Parkinson’s disease (PD), etc.
Experimental Gerontology Volume 176, 1 June 2023, Mediterranean diet and mitochondria: New findings • Mediterranean diet (MedDiet) seems to affect the function of mitochondria. MedDiet reduced mitochondrial reactive oxygen species (mtROS) production. Other components of MedDiet can have anti-inflammatory effects. Several positive effects of MedDiet can be mediated by a modulation in mitochondrial function.
How Tired is Too Tired to Drive? A Systematic Review Assessing the Use of Prior Sleep Duration to Detect Driving Impairment
https://www.dovepress.com/article_82764.t183124640
IET Peter Wells Memorial Lecture 2023 – How to Live Past 120 – Ronjon Nag, Adjunct Professor in Genetics Stanford University03 May 2023 / 6:00pm – 9:00pm
Good list of nutritional, supplemental and physical activity actions that can promote healthy longevity by affecting epigenetics. In this review, we describe how aging impacts epigenetics and how nutrition and physical exercise can positively impact the aging process, from an epigenetic point of view. Canonical histones are replaced by histone variants, concomitant with an increase in histone post-translational modifications. A slight increase in DNA methylation at promoters has been observed, which represses transcription of previously active genes, in parallel with global genome hypomethylation. Aging is also associated with deregulation of gene expression – usually provided by non-coding RNAs – leading to both the repression of previously transcribed genes and to the transcription of previously repressed genes.
Another study on the value of melatonin for healthy longevity.
I particularly noted the following summary of the healthy longevity and anti-cancer benefits of melatonin listed in the study paper Introduction.
ChatGPT, an AI-based language model, was able to predict Alzheimer’s in 80% of cases when analyzing speech.
A recent study investigated the potential of rapamycin to slow down skin senescence when applied topically as a cream. Patients who underwent the treatment exhibited a significant reduction in senescence markers. The study found that the treatment either prevented cells from entering senescence or increased the clearance of senescent cells.
Will AI Change Health Care? The short answer is: “You betcha!!” In a very interesting research project described in a paper released last November. Zijiao Chen, a doctoral student at the National University of Singapore used the combination of functional MRI (fMRI) and artificial intelligence to identify “pictorially” the thoughts of individuals who looked at pictures of common objects (e.g. a firetruck) while undergoing fMRI analysis. Later the AI was trained to recognize the brain waves as the same as the picture so that when the individuals were shown similar pictures, the AI was able to replicate sometimes very accurately and sometimes close to the original, a picture of what the brain waves were seeing. This means that over time as the AI function is taught, it could most likely be able to interpret brain waves and the visual impressions made in the brain.
WebMD-Fight inflammation-10,000IU vitamin A for a week after exercise injury, bromelin (pineapple juice), capsaicin, turmeric, vitamin E, garlic (2-4cloves), ginger, fish oil, resveratrol, SAMe, zinc.
