SUBJ: megadosing vitamin C SLASHES Stage IV cancer death risk.
SUBtitle: Foods that cause gas: apples, avocadoes, beans, broccoli,…
Overcome regret and fear through meditation. Hariya Sekiun
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SHORT NOTES:
1..A new study found megadosing vitamin C SLASHES Stage IV cancer death risk.
2..Foods that cause gas: apples, avocadoes, beans, broccoli,…No wonder I have so much gas!
3..Natural variation in RNA molecules could influence human traits such as height and weight.
4..Ancient DNA shows “massive” genetic shifts tied to rise of farming, wheels, and metal tools.
5..The brain’s expression of more than 3000 genes differs between men and women.
6..Engineered immune cell precursors produce antibodies on demand in mice.
7..Vaccines have transformed global health through controlling or eradicating infectious diseases.
8..The price of the anticancer drug Keytruda doubled when administered in a hospital.
9..Our work showed IV vitamin C improved outcomes, and a few cures.
10..EvORanker determines which gene is likely causing a patient’s symptoms.
11..Pancreatic cancer treatment ready for trials.
12..Reservist’s organs save 4 patients.
13..Extra-chromosomal DNA (ecDNA) that get scattered throughout the nucleus of a cell.
14..People with higher consumption of sugar substitutes end up putting on more weight.
LONG NOTES:
A new study found megadosing vitamin C SLASHES Stage IV cancer death risk in HALF and DOUBLES time left to live. This isn’t surprising given HUNDREDS of preclinical studies already show vitamin C eliminates cancer cells through four powerful mechanisms: 1. Oxidative tumor destruction 2. Epigenetic reprogramming 3. Oncogenic signaling suppression 4. Immune activation. Note taking Triumph as prescribed provides megadoses of vitamin C to your bladder twice a month.
Foods that cause gas: apples, avocadoes, beans, broccoli, brussel sprouts, cabbage, cantaloupe, cauliflower, corn, cucumber, honeydew melon, lentils, onions, peas, radishes, sauerkraut, turnips, watermelon – No wonder I have so much gas!
Science 16 Apr 2026 pg240 – But there’s growing evidence of natural variation in the genes coding for the RNA molecules that help make up a ribosome’s structure. Now, a new study, based on data from hundreds of thousands of people in the UK Biobank, suggests this variation could influence human traits such as height and weight—and perhaps represents a major overlooked driver of human diversity.
Science 16 Apr 2026 pg241 – Ten thousand years ago, human evolution went into overdrive. Ancient DNA reveals “massive” genetic shifts tied to rise of farming, wheels, and metal tools.
Science 16 Apr 2026 pg251- Express yourself – The brain’s expression of more than 3000 genes differs between men and women.
Science 16 Apr 2026 pg252 – Programmable cellular protein factories. Engineered immune cell precursors produce antibodies on demand in mice. Vaccines have transformed global health through their role in controlling or eradicating infectious diseases. For example, they can elicit B cells to produce antibodies that recognize different strains of a particular pathogen. However, conventional immunization with weakened or inactivated pathogens, or a component of the pathogen, is often difficult because the relevant precursor B cells are rare and the process by which they generate antibodies with increased affinity to the pathogen’s antigens is complex and lengthy (1). Strategies that enable durable delivery of protein therapies have applications beyond vaccines but rely on repeated dosing and can be hampered by how the body processes the drug, manufacturing costs, and patient adherence to treatment. On page 273 of this issue, Hartweger et al. (2) report an approach in which engineered mouse hematopoietic stem and progenitor cells (HSPCs) generate B cell precursors that can be expanded into antibody-secreting cells through conventional immunization.
The price of the anticancer drug Keytruda doubled when administered in a hospital outpatient setting compared to in a doctor’s office, $162,567.74 for a 400 mg dose.
COMMENT 1: I think your title is a little too optimistic. Our work showed improved outcomes, and a few cures, but not for everyone. Comment 2: ASC didn’t cure anyone’s pancreatic cancer. It did, however, lengthen their survival time. And that was in conjunction with chemotherapy with two agents. About a third of the subjects in the chemo plus ASC group didn’t make it to ten months. Unfortunately, pancreatic cancer is still basically a death sentence.
Disease gene finder. (TY TPS) Researchers at Jerusalem’s Hebrew University have developed EvORanker to determine which gene is likely causing a patient’s symptoms. In tests, EvORanker outperformed existing tools, especially when the gene had not previously been linked to disease.
Pancreatic cancer treatment ready for trials. Israel’s Silexion Therapeutics (see here previously) received Israeli Ministry of Health approval to initiate a Phase 2/3 trial of SIL204 in locally advanced pancreatic cancer, marking advancement to clinical-stage development. SIL204 targets a range of common KRAS mutations.
Reservist’s organs save 4 patients. Staff Sergeant Effi Ben-Yakar, a reservist in a special unit suffered cardiac arrest during leave and passed away at Ichilov Hospital. His lungs went into a 38-year-old woman; his liver into a 71-year-old man and his kidneys into two men, aged 40 and 64.
Economist Apr 18, 2026 pg78- some cancer cells refuse to play along. His work reveals that in about 20% of human cancer samples some DNA escapes from the chromosomes to which it is normally bound and forms tiny, circular bodies of extra-chromosomal DNA (ecDNA) that get scattered throughout the nucleus of a cell. Thus scattered, they are no longer subject to the rigours of mitosis, the conventional process by which chromosomes divide into two identical copies, one for each daughter cell. This adds an element of unpredictability to how genes are inherited, allowing mutations to occur faster and on a more dramatic scale.
Economist Apr 18, 2026 pg79-The promise of sugar substitutes is simple: found in everything from yogurts to toothpaste, they claim to let people gorge on sweet treats without piling on weight and the tooth decay caused by sugar-loving bacteria. Now a growing body of research is suggesting that these substances may have surprisingly bitter consequences.
Sugar substitutes are a mixed sachet. They include synthetic concoctions (such as aspartame, saccharin and sucralose) and substances derived from plants, including a family of carbohydrates known as sugar alcohols (such as erythritol, maltitol, sorbitol and xylitol) and stevia. Some strike the human tongue as hundreds of times sweeter than sugar, so are added in tiny amounts to foods and drinks. These small quantities, combined with the observation that many are excreted largely unchanged, have led to the assumption that they pass through the human body without affecting metabolism.
Things may not be so simple. In some randomised controlled trials (typically lasting 4-12 weeks) substituting other sweeteners for sugars did admittedly result in lower weight gain. But a number of large, long-term observational studies have found the opposite: people with higher consumption of sugar substitutes—some of whom may be using these to replace sugar in their diets—end up putting on more weight than those who consume the least. Other studies show that they also end up with higher rates of heart problems, diabetes and cancer than abstainers.
Proving causality through such observational studies is difficult, as it would involve accounting for all the ways in which people who eat lots of sugar substitutes are different from those who do not. It could be, for example, that some consumers of these sweeteners are people who are already at high risk for diabetes or heart disease and looking to eat more healthily. Even without a smoking gun, however, the overall body of research was concerning enough to prompt the World Health Organisation to issue, in 2023, precautionary advice against the use of sugar substitutes as a means to control weight or prevent chronic diseases. (The advice does not apply to people with diabetes.)
There are plenty of hypotheses concerning how sugar substitutes could be causing harm. Some of these substances have been found to activate the same harmful gut and metabolic signalling mechanisms as sugar, and some studies in mice suggest that they could be affecting the function of immune cells involved in preventing the growth of tumours. Emerging evidence also suggests that they can affect the relative abundance of various gut bacteria, potentially tipping the scales in favour of harmful species. There are lots of open questions to be answered regarding the safety of sugar substitutes, says Herbert Tilg from the Medical University of Innsbruck, in Austria, but these studies are raising the level of concern.
