Rapamycin
Rapamycin is widely used by diabetics and others, but is being considered by the FDA as an anti-aging drug. Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.
2024 – from GRG discussion-Rapamycin is a bit of an odd exception here among supplements. The primary reason to cycle it (taking it e.g. once a week instead of daily) is because that’s the only reasonable way to prevent the excessive mTORC2 inhibition which is responsible for many of the negative effects of rapamycin when taken too frequently. Dosage of 5mg/week seems common choice.
Not taking rapamycin may be as dangerous as smoking
Strangely, the fear of tobacco smoking is less intense than the fear of rapamycin. But whereas smoking shortens both the healthspan and lifespan, rapamycin extends them. Smoking increases the incidence of cancer and other age-related diseases.
HOWEVER, It may accelerate Alzheimer’s. Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have found that oral administration of rapamycin to an Alzheimer’s disease mouse model causes an increase in beta (β)-amyloid protein plaques. β-amyloid buildup is a hallmark of Alzheimer’s disease.
