Melatonin
I am impressed by all the evidence since 2022 that melatonin may well be an anti-aging supplement. I now take 20 mg every night just before bedtime. For lots more about melatonin, including the studies of how it activates youthful genes and turns off aging genes, see here.
5/25/22 – Melatonin: A novel candidate for the treatment of osteoarthritis. melatonin reportedly promotes synthesis of cartilage matrix, inhibition of chondrocyte apoptosis, attenuation of inflammatory response, and suppression of matrix degradation by regulating the TGF-β, MAPK, or NF-κB signaling pathways.
Melatonin promotes peripheral nerve repair through Parkin-mediated mitophagy
https://doi.org/10.1016/j.freeradbiomed.2022.04.01612/22/2020 – Results from a new Cleveland Clinic-led study: Melatonin usage may help prevent COVID-19 infection
Before I learned of the research in 2022, I, Roc Ordman, took 3mg of melatonin four nights a week, since about 1990. I learned at an AGE meeting years ago that taking melatonin turns off genes that make us old, and turns on genes that make us young, but that presentation was never published. Now, Advances in Nutrition reports that daily doses of melatonin over 1mg converts white adipocytes which store fat into brown adipocytes which burn fat and produce muscle. Daily melatonin (at least 1mg up to 5) reduces obesity in post-menopausal women. In response to treatment, fat mass decreased in the melatonin group by 6·9% compared to placebo. A borderline significant increase in lean mass of 5·2% was found in the melatonin group compared to placebo. Mar 2020 Adv Nut
More reasons to take melatonin
I have found no one opposed to taking melatonin
