KLOTHO

Klotho is an enzyme that in humans is encoded by the KL gene.[5] There are three subfamilies of klotho: α-klotho, β-klotho, and γ-klotho.[6] α-klotho activates FGF23, and β-klotho activates FGF19 and FGF21.[7] When the subfamily is not specified, the word “klotho” generally means the α-klotho subfamily.[8]

I will share cohort experience with Klotho on muscle-mass.         Cohort have experienced an increase in muscle-mass following the administration of soluble human Klotho,. To me: I just need to exercise a bit and my muscles arms are back as my 20ish, similar to my father in law upper body muscles, a colleague leg-muscles she is improving her running performance, etc..

This is a research I found linked with that: Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle“…muscle stem cell numbers are significantly decreased in klotho hypomorphic mice. Furthermore, we show that muscle stem cell function is also severely impaired upon loss of klotho expression, in culture and during regeneration in vivo. Moreover, we demonstrate that addition of recombinant Klotho protein inhibits aberrant excessive Wnt signaling in aged muscle stem cells thereby restoring their functionality.” https://pubmed.ncbi.nlm.nih.gov/29973273/. . here are other researches and benefits provided by Klotho, ie. Stem-cells functioning and differentiation shift, enhance brain function, suppress renal fibrosis, inflammation, cancer, etc.

You might try this peptide, it will also give additional benefits, the most impressive one is the face skin, within 1 week you will see the rejuvenation effect watching yourself on the mirror while shaving. I am reporting below a brief description of the benefits we have noticed (the blood biomarkers are mine only):

Klotho effects

  • Skin becoming thicker and tighter, deep wrinkles reduced
  • Hair slower growth (men: beard, lady: hair and body, hair shaft dying from 3 weeks -> 5weeks)
  • Near sight improves and sight is brighter
  • HRV shift to parasympathetic
  • Feeling a mental and skin “fresh” sensation
  • Stomach feeling full with normal eating, should help with weight reduction
  • Waking blood sugar goes down
  • Diastolic increase ~10, pulse reduced significantly
  • Increase energy level
  • Muscle regrowth (ie . Arms, legs)
  • Blood markers improves by 15-20%: LDL, Thyroids, liver, testosterone, Lymphocytes

I am also reporting the side effects of Klotho excess, pay attention on the dosing in case you want DIY ~5pg/week as maintenance dose, monitor the blood-pressure as it goes down.

Excess of Klotho: Legs cramps; low energy, running pace slowdown; Orthostatic Hypotension: stand up quickly feel dizzy or lightheaded

Regards, Marcello

Klotho he uses is an injection. Here is the website where he buys it: https://www.abcam.com/recombinant-human-klotho-protein-active-ab84072l