Genistein
Genistein is a natural compound found in soy. It has been used reduce symptoms of menopause and to help control blood glucose. It has also been used to help lower chances of prostate and breast cancer. Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. 15-PGDH may be a suitable therapeutic target for countering sarcopenia. Genistein inhibits 15-PGDH.. On this evidence, Roc began taking 125 mg daily. When I first checked for safety, a hospital website reported that Genistein is safe as a supplement.
2023 – Due to the neuroprotective, anti-oxidative and anti-inflammatory properties, Genistein (GEN) is used to restore or improve memory functions in different animal models and humans.
HAZARD: However, the next day a colleague provided links indicating that genistein may be hazardous to health. Cancer Res. 1997 Sep 1;57(17):3717-22.
Enhancement of experimental colon cancer by genistein
Cell Death Dis. 2018 Oct 17;9(11):1055. doi: 10.1038/s41419-018-1059-y.
Down-regulation of HPGD by miR-146b-3p promotes cervical cancer cell proliferation, migration and anchorage-independent growth through activation of STAT3 and AKT pathways
Shuihong Yao, Jingyun Xu, Kaixuan Zhao, Pengxia Song, Qin Yan, Weifei Fan, Wan Li, Chun Lu
https://pubmed.ncbi.nlm.nih.gov/30333561/
PLoS One. 2019 Jan 25;14(1):e0211368. doi: 10.1371/journal.pone.0211368. eCollection 2019.
The association between urinary genistein levels and mortality among adults in the United States
Carolyn Marcelo 1, Melissa Warwick 1, Catherine Marcelo 1, Rehan Qayyum 1
https://pubmed.ncbi.nlm.nih.gov/30682197/
For the complete report with surprising figures and discussion:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347457/
Although the last citation is the scariest, it is an association based on NHANES data rather than a clinical trial. On that basis, I would be cautious about using Genistein.
