Alpha-GPC (L-alpha-glycerylphosphorylcholine)

Alpha-GPC is a chemical made in the body from choline. It is also made in a lab and used in dietary supplements. It is likely to be hazardous.

Int J Mol Sci. 2021 Dec; 22(24): 13477.

Published online 2021 Dec 15. doi: 10.3390/ijms222413477

L-alpha glycerylphosphorylcholine (GPC), a nutritional supplement, has been demonstrated to improve neurological function. However, a new study suggests that GPC supplementation increases incident stroke risk thus its potential adverse effects warrant further investigation.

WebMD –  Alpha-GPC seems to increase the levels of a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions.

People use alpha-GPC for Alzheimer disease, stroke, memory and thinking skills, and other conditions, but there is no good scientific evidence to support these uses.