SUBJ: Fasting and exercise perhaps starve even undiagnosed cancer cells to death.
SUBtitle: COVID-19 mRNA Shots may give a 25% Lower Risk Of Death From Any Cause.
To err is human, to repent divine, to persist, devilish. Poor Richard’s |Almanac
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SHORT NOTES:
1..Fasting and exercise perhaps starve even undiagnosed cancer cells to death.
2..COVID-19 mRNA Shots may give a 25% Lower Risk Of Death From Any Cause.
3..The Annual Christmas and Hannukah holidays are upon us…let us be glad in it!
4..Subjective cognitive decline predicts neuropsychological test performance.
5..Mice Blood Age Affects Alzheimer’s Brain Changes.
6..Immunotherapy has changed the outlook for several blood cancers worldwide.
7..The gut microbiome influences immunity, metabolism, and the nervous system.
8..How nutrient-dense nuts can unlock health benefits. Have a handful daily!
9..In September, the Diet and Optimum Health Conference at the Linus Pauling Inst.
10..The Daily Barrage of Incivility and Immorality – I’m a “peacenik” personality.
11..Why the bowhead whale has a long life of around 200 years.
LONG NOTES:
From Nature Briefing: In mice, exercise causes muscles to metabolize glucose that would have otherwise fueled cancer growth. Accordingly, might fasting and exercise during that fasting significantly diminish the amount of glucose available and perhaps starve any cancer cells to death, including those that are as yet undiagnosed.
Large New Study Finds COVID-19 mRNA Shots Associated With 25 Percent Lower Risk Of Death From Any Cause
The Great – The Annual Christmas and Hannukah holidays are upon us…let us be glad in it!
Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry (I am in this study)
Mice Blood Age Affects Alzheimer’s Brain Changes
Overall, this study supports the idea that blood is not just a passive carrier but a powerful modulator of brain health during aging and disease. While young blood has been associated in previous work with improved synaptic function and reduced amyloid and tau changes, this study emphasizes the harmful impact of old blood, particularly on cortical amyloid patterns and memory.
Immunotherapy, which re-arms T-cells with synthetic receptors to seek and destroy malignant cells, has already changed the outlook for several blood cancers worldwide and is steadily expanding in Israeli hospitals through tightly regulated clinical programs.
The gut microbiome influences immunity, metabolism, and the nervous system. Exploring disruptions in gut microbial communities may be an avenue to address chronic disease. New research from the Linus Pauling Institute is revealing how environmental exposures can influence health across the lifespan and even across generations. In a recent study, principal investigator Dr. Thomas Sharpton, in collaboration with Dr. Robyn Tanguay, showed that, in zebrafish, early-life exposure to a common pollutant can alter the gut microbiome, change behavior, and produce effects in future generations of offspring who were never directly exposed. By uncovering how pollutants interact with gut microbial communities through signaling pathways involving the aryl hydrocarbon receptor (AhR), which is involved in development, immunity, and metabolism of foreign compounds, Sharpton’s research highlights new opportunities for earlier detection and disease prevention.
Small snacks can make big impacts! A panel of faculty and student experts from OSU’s Linus Pauling Institute and College of Health will share findings on how nutrient-dense nuts, such as hazelnuts, almonds and walnuts, can unlock health benefits to improve your cardiometabolic, cognitive and gut health.
In September, we hosted our Diet and Optimum Health Conference, bringing together 22 researchers from across the U.S. and beyond to share the insights and questions driving their investigations into precision nutrition and factors that increase healthspan. Check out the conference website for event photos, speaker profiles, and poster session abstracts.
My Shared thoughts written by Kevin Fickenscher: The Daily Barrage of Incivility and Inadequate Morality – I’ve come, after all these years, to anticipate that “wars” are often an inevitable outcome among conflicts that evolve between nations throughout the world. At the same time, I must admit that I’m a “peacenik” personality. I was that type of person when I came of age in the 1960s as the Vietnam War raged on in Southeast Asia. In fact, I must admit I can’t think of an intergovernmental conflict that required war – with the exception of WW II, which occurred slightly before my presence here on Mother Earth. It’s why I wear a peace medallion now – and have done so periodically since the 1960s.
Longer Life…Sure – Quality Life…Maybe – A recent synopsis in Popular Mechanics reported on a new finding from the study of whales, suggesting a method for extending life. The study comes from an examination of the bowhead whale (Balaena mysticetus). These whales are unique among the mammalian species due to their extended lifespan of around 200 years, despite their 100-ton average weight!! And, the extent of their lifespan is well documented by scientists, Alaskan Inupiat hunters, and locals living in the north. In fact, the oldest documented bowhead whale lived to 211 years. So, the question is: Why?
According to a journal article by researchers at the University of Rochester, the bowhead whale contains an unusually high concentration of a protein called Cold-Inducible RNA-Binding Protein (CIRBP), which is found in humans as well. Basically, the CIRBP binds to RNA and helps cells regulate their response to stress, which can come from cold exposure, hypoxia, heat shock, UV radiation, inflammation, and other similar stressors. It accomplishes this regulation by repairing the double-strand breaks that often occur in the double helix when cells are stressed. Without the breaks – the cells live longer. Now, while living longer is obviously attractive – especially as one gets older, the question of quality of life comes quite quickly to the forefront. Studies have yet to be done to check on the “quality” issues faced by the bowhead whales. And, is it lifetime of continuous swimming in the oceans that makes a difference? I’ll keep an eye out for any other research coming down the pike!! And, perhaps I’ll take up swimming…
