SUBJ: Overweight chronic back pain is associated with sarcopenia

SUBtitle: ER1 is drug injected in the eye that may cure blindness

Observing without evaluating is the highest form of human intelligence – Krishnamurti

Serve with integrity and empathy – Jimmy Kolker ’70 Carleton College

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SHORT NOTES:

1..In older patients with chronic low back pain, a high waist–calf circumference ratio was associated with severe sarcopenia.

2..Chronic low back pain is a prevalent, disabling conditions in the older population.

3..Prof. Sinclair of Harvard Univ.– ER1 is drug injected in the eye to cure blindness.

4..Nature made is the only major USP certified nutritional supplement.

5..Behind tobacco and obesity, (excessive) alcohol drinking is the third-leading preventable cause of cancer.

6..Self effective – Rapid Eye Movement improves the processing of traumatic emotion.

7…Consequences of federal VA hiring freeze has been the termination of curing many diseases.

8..Gene deletion shrinks cancer cells.

9..Blood test to detect cancer.

10..Anti-virus nasal spray for the US.

11..All EU countries showed improved life expectancy from 1990 to 2011 and 2011 to 2019.

12..A podcast on Hyperbaric Oxygen therapy for stroke recovery.

13..HBOT may be one of the highest-value health therapies.  With an opposing opinion from a toxicologist, HBOT also increases the displacement of CO from arterial Hb.

LONG NOTES:

Evaluation of Waist–Calf Circumference Ratio to Assess Sarcopenia in Older Patients with Chronic Low Back Pain: A Retrospective Observational Study. In older patients with chronic low back pain, a high waist–calf circumference ratio was associated with severe sarcopenia, characterized by reduced muscle strength and impaired physical performance.

 

Chronic low back pain (CLBP) is one of the most prevalent and disabling conditions in the older population.¹ Among these individuals, the prevalence of sarcopenia is notably higher, particularly in those with symptomatic degenerative lumbar spine disease, compared to those without pain.  Among 592 patients, 85 had sarcopenia (14.3%), and 71 had severe sarcopenia (11.9%).  In older patients with chronic low back pain, a high waist–calf circumference ratio was associated with severe sarcopenia, characterized by reduced muscle strength and impaired physical performance (Q1=7.9%, Q2=8.6%, Q3=14.8%, Q4=16.9%). The waist–calf circumference ratio might serve as a useful tool for assessing sarcopenia in this population.  Waist hip ratio Q1 <2.56; Q4 > 2.9

 

Prof. David Sinclair of Harvard Univ. is an expert on aging.  Here is a fascinating hour long interview. 12 hallmarks of aging; Information theory of aging; epigenetic changes may be key driver, fasting turns on sirtuin genes (silent turn down inflammation genes)-they activate lots of anti-aging processes, catch indications of cancer, heart disease, dementia early to prevent them. Discovered and favors resveratrol, helps cardiovascular system-must take it with something oily, not absorbed without oil.  Does not see benefit with rapamycin short term; metformin – he prefers berberine which has the same benefits, revs up mitochondria; many other benefits to wegovy which does cause muscle loss unless get lots of exercise; epigenetic reprogramming of 3 Yamanaka genes to rejuvenate cells – ER1 is drug injected in the eye to rejuvenate blindness. He hopes for a drink in a few years to rejuvenate people. His book “Lifespan: Why we age, and why we don’t have to.”

 

Nature made – USP certified nutritional supplements. I spent hours searching the links I gave for certified supplements. The only one that was impressive is Nature Made.  I am switching my supplement buying links to that brand if they supply that product.

 

Continuing the Legacy: Understanding and Reducing Tissue Aging to Prevent Many Currently Incurable Diseases. Behind tobacco and obesity, (excessive) alcohol drinking is the third-leading preventable cause of cancer. Heavy drinkers — which the National Institute on Alcohol Abuse and Alcoholism defines as men who consume five or more drinks on any day or 15 drinks or more per week, and women who have four or more drinks on any day or eight or more per week.  Breast (in women), Colorectum, Esophagus, Liver, Mouth (oral cavity), Throat (pharynx), Voice box (larynx)

 

Message: Have you heard of Se-REM? (Self effective – Rapid Eye Movement). Many people don’t know that REM brain activity dramatically improves the processing of traumatic emotion. It creates peace and empowers the listener.  Se-REM is an advanced version of EMDR therapy. It is more powerful because it combines elements of 6 different therapies, EMDR, hypnosis, mindfulness, Gestalt child within work, music therapy, and Awe therapy, (connecting profoundly with nature).  Classical music alternates between the ears to enhance daydreaming and visualizing in ways you have never experienced.  Please read the many reviews that express how much it has helped.
It has helped thousands of people overcome PTSD, and anxiety. But it is also helpful in a great many situations, any experience that has been traumatic.    Se-REM’s mission statement is “Trauma relief at as close to free as possible”. This not-for-profit program downloads to a smart phone or computer and can be used at home.
Read and download at: Se-REM.com.   Once you own the program, you are encouraged to give it away to others who will benefit. Se-REM.com  is in use in 33 countries.

 

US Department of Veterans Affairs … “has contributed to many significant advances in medicine. Much of this vital research has come from joint faculty appointments between VA and their academic partners. One of the unforseen consequences of the recent federal hiring freeze has been the termination of many of these joint term limited research appointments.

Gene deletion shrinks cancer cells. Researchers from Tel Aviv University (Dan Peer’s lab) utilized CRISPR to cut the SOX2 gene from cancer cells of head and neck tumors – and in lab tests successfully eliminated 50% of the tumors. The breakthrough defied general belief that knocking out a single gene wouldn’t have any effect.

 

Blood test to detect cancer. Israel’s OncoRedox is developing a new platform for the early diagnosis and monitoring of cancer and chronic diseases. Its disposable sensor plus AI-powered technology is designed to detect and profile cell-free metabolites within minutes, providing a unique metabolic fingerprinting.

Anti-virus nasal spray for the US. Israel’s Enovid (see here previously) has now launched its SaNOtize Nitric Oxide Nasal Spray as NOWONDER in the US. NOWONDER delivers advanced nasal cleansing, viral protection (e.g. against COVID-19), and sinus health support.

 

When analyzed separately, all EU countries showed improved life expectancy from 1990 to 2011 and 2011 to 2019; however, the rate varied. Confirming the observations of bulk data analysis reported previously, the rate of life expectancy improvement was higher in the 1990-to-2011 period than the 2011-to-2019 period.

 

From GRG: Hyperbaric Oxygen therapy for stroke recovery.  A post stroke podcast for recovery.

 

[GRG] Bryan Johnson claims HBOT is one of the highest-value health therapies he has ever done.  With an opposing opinion: Writing as a toxicologist, the greatest threat posed by HBOT is that oxygen boosts HO-1 activity, which  increases how much CO you make per minute and how much you accumulate (usually a little more than half).  HBOT also increases the displacement of CO from arterial Hb into arterial plasma and the diffusion of this CO from there into your muscles and organs, where CO is much more harmful than if left in blood.