SUBJ: Pregnant women especially must get enough iodine.
SUBtitle: GDF11 makes the hearing hair cells healthy and eliminated need for hearing aids.
“My actions are my only true belongings.” ― Thich Nhat Hanh
I was asked to write an essay with guidance on how to go grocery shopping. Here is the link.
Links for new readers: 1) One Day in Roc’s Life: 46 resolutions to prolong health span 2) Recent important nutrition news. 3) A contribution to this newsletter is healthier and less expensive than your multivitamin. Donation link:Nutrition Newsletter
SHORT NOTES:
Pregnant women especially must get enough iodine.
If what this book predicts about the future comes true, we are in for some incredible improvements in terms of our health and longevity.
If you can live long enough for anti-aging research to start adding at least one year to your remaining life expectancy annually, that will buy enough time for nanomedicine to cure any remaining facets of aging.
GDF11 makes the hearing hair cells healthy and eliminated need for hearing aids.[I plan to try doing this!]
Dance and martial arts upregulated Brain Derived Neurotrophic Factor levels, with dance showing notable improvements in cognitive function and mood in older adults.
This meta-analysis provides significant evidence of positive association between higher saturated fat intake and AD and dementia risk.
High-Fat Diet administration (nearly 75% of energy) for five days is sufficient to induce depression and impair retrieval speed and attention.
The green leafy variety has been identified as having the strongest protective effects against cognitive decline.
“High-quality diets that are associated with better cognitive function and lower dementia risk with aging are high in vegetables, fruits, nuts, whole grains, and fish and low in red meat, high-fat dairy products, sweets, and highly processed foods.”
Antibody to combat cancer. Lab tests were successful at treating triple-negative breast cancer.
Controlling blood sugar levels is a significant key mechanism linking diet to slower brain aging.
Allocetra cell therapy is in Phase II clinical trials on patients with osteoarthritis of the knee’
From GRG: Here’s a useful video about food for clean arteries.
A collection of the new 12 papers on ~20 types of cancer, from more than 2,000 individuals, at multiple levels (as shown above) represents a formidable body of work.
Their leading drug candidate is Ivonescimab, an immunotherapy treatment being tested on non-small cell lung cancer (NSCLC).
LONG NOTES:C
Economist Nov 9 pg 68 –Pregnant women especially must get enough iodine. Because many sources of iodine like regular milk and iodized salt are less common in American diets, iodine levels are low in many children, women, and especially during pregnancy. Deficience during pregnancy can lead to stillbirth, miscarriage and stunting. Meat and fish are good sources, and iodized salt.
Ray Kurzweil’s book The Singularity Is Nearer: When We Merge with AI. If what this book predicts about the future comes true, we are in for some incredible improvements in terms of our health and longevity. Here is part II of a summary of his predictions:
• In order to stop (or cure) aging, we need the ability to repair damage from aging at the level of individual cells and local tissues.
• A combination of AI and nanotechnology will enable us to redesign and rebuild – molecule by molecule – our bodies and brain and the world we live in.
• And we don’t need to wait until these technologies are fully mature to benefit. If you can live long enough for anti-aging research to start adding at least one year to your remaining life expectancy annually, that will buy enough time for nanomedicine to cure any remaining facets of aging. That is the point of longevity escape velocity.
I am 87 years old and I had hearing loss requiring a hearing aid with very little above 4000. About six years ago, I started with Steve Perry to taking GDF11 growth differentiation factor 11 subcutaneous. After an initial loading dose of about 20,000 picograms over about two months or so. It was reduced to once a week. My hearing improved significantly so that I no longer needed a hearing aid and I can hear music and television and ordinary conversation, although my hearing’s not as good as when I was younger. There is a science article from several years ago that the progenitor cells must have GDF11 to make the hearing hair cells. Now my wife and I take 10 picograms of GDF 11 weekly. GDF11 also does other good things for you, repairs DNA of stem cells, et cetera. We also take one picogram subcutaneous daily of klotho. Day McNeel MD.
The Effect of Two Somatic-Based Practices Dance and Martial Arts on Irisin, Brain Derived Neurotrophic FactorLevels and Cognitive and Physical Fitness in Older Adults: A Randomized Control Trial. Conclusion: The study found that dance and martial arts upregulated Brain Derived Neurotrophic Factor levels, with dance showing notable improvements in cognitive function and mood in older adults. Changes in anthropometric measures were linked to increased irisin levels. These findings suggest that both dance and martial arts may promote healthy brain function in aging populations.
Conclusion from a meta-analysis: “Dietary Fat Intake and Risk of Alzheimer’s Disease and Dementia: A Meta-Analysis of Cohort Studies” by Yue Ruan et al. Meta-Analysis Curr. Alzheimer Res., 2018;15(9):869-876. “Conclusions: This meta-analysis provides significant evidence of positive association between higher saturated fat intake and AD and dementia risk.”
Nutrients. 2019 Nov; 11(11): 2579. “Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function,” by Tan and Norhaizan. Of particular note is section 3.2:
“Holloway et al. found that High-Fat Diet administration (nearly 75% of energy) for five days is sufficient to induce depression and impair retrieval speed and attention. Consistent with a study reported by Holloway et al., Edwards et al. demonstrated that HFD consumption for seven days reduced attention and reaction time in sedentary adult males”
“Among the different types of vegetables, the green leafy variety has been identified as having the strongest protective effects against cognitive decline. In the Rush Memory and Aging Project, the rate of decline among those who consumed 1–2 servings per day was the equivalent of being 11 years younger in age compared with those who rarely or never consumed green leafy vegetables.”
“High-quality diets that are associated with better cognitive function and lower dementia risk with aging are high in vegetables, fruits, nuts, whole grains, and fish and low in red meat, high-fat dairy products, sweets, and highly processed foods.”
Another antibody to combat cancer. Following last week’s Israeli cancer breakthrough (see here), now Weizmann Institute researchers have found an antibody (against CD84) that prevents tumors building molecular bridges from suppressing the immune system. Lab tests were successful at treating triple-negative breast cancer.
Low blood sugar and green Med diet. An international study led by Israel’s Ben-Gurion University scientists showed controlling blood sugar levels is a significant key mechanism linking diet to slower brain aging. The 300-participant study was one of the longest and largest brain MRI trials in the world.
Treatment for knee osteoarthritis. Denmark’s Medicines Agency has approved Allocetra cell therapy from for Phase II clinical trials on patients with osteoarthritis of the knee. From Israel’s Enlivex (see here previously) . 40% of men and 47% of women develop knee osteoarthritis in their lifetimes. Allocetra also treats Covid and cancer.
From GRG: Here’s a useful video about food for clean arteries.
A collection of the new 12 papers on ~20 types of cancer, from more than 2,000 individuals, at multiple levels (as shown above) represents a formidable body of work, to say the least. The journals included not just Nature but also Nature Cancer, Nature Medicine, Nature Methods, and Communications Biology. Our unprecedented capability to define human biology at the pan-molecular, cellular, and tissue levels, and see things that were previously not discernible, is laying the foundation for important progress.
Their leading drug candidate is Ivonescimab, an immunotherapy treatment being tested on non-small cell lung cancer (NSCLC). The stock is trading up 627% year-to-date (YTD) on the belief that it could be a game-changer in the fight against advanced lung cancer. Its stunning Phase 3 clinical trial results shocked the medical sector.
