How long you balance on one leg shows your real age
SUBtitle: Quercetin is a promising treatment for allergic diseases
“We can choose how to live our lives now. We can seize any moment and begin anew.” Thich Nhat Hanh
Lots of nutrition news as we set the clocks back an hour and survive the US election.
Links for new readers: 1) One Day in Roc’s Life: 46 resolutions to prolong health span 2) Recent important nutrition news. 3) A contribution to this newsletter is healthier and less expensive than your multivitamin. Donation link: Nutrition Newsletter
SHORT NOTES:
1..Better measure of aging than changes in strength or gait. How long you balance on one leg!
2..Quercetin is a promising treatment for allergic diseases.
3.. Stem cell therapy is a promising treatment for Osteoarthritis.
4..Obstructive Sleep Apnea promotes the formation of kidney stones.
5..Substituting Sedentary Behavior with an adequate amount of sleep or engaging in vigorous Physical Activity emerges as an effective strategy for reducing stroke risk.
6..The study revealed causal associations between sleep duration, sleep-wake disorders, and low grip strength.
7..Delaying retirement for just one year can decrease a person’s mortality rate by 11%.
8..Inhaling lavender really does inhibit pain receptors to provide relief from pain.
9..Vitamin E and selenium supplementation increases the risk for prostate cancer!
10..Potential Anti-Rheumatoid Arthritis Candidate, Levamisole.
11..Cyperus rotundus ameliorates Osteoarthritis.
12..BMI and Waist-to-Height Ratio are associated with Obstructive Sleep Apnea and short sleep duration.
13..People with a history of childhood obesity should pay more attention to physical examination to early prevention and management of sleep apnea syndrome.
14..One jab to treat them all! Ozempic reduces brain inflammation likely preventing Alzheimers, decreases heart attacks and strokes, lowers metabolic liver disease, lowers risk of diabetic kidney disease, increases insulin synthesis and secretion. And there are lots more of these drugs being developed that will be much less expensive!
15..Methylation clocks seem most accurate to determine healthspan age. Doctors should just recommend better diet and more exercise.
16..Rejuvenate skin with your own cells, an organic treatment that improves skin elasticity, diminishing wrinkles and scars.
17..Skin aging, one of the most visible forms of aging, may be relieved bt a rejuvenating effect of HALPN1with a possible role in depositing collagen and hyaluronic acid in aged skin.
18..AI alerts of an impending stroke indicating that 80% of strokes are preventable.
19..New metabolites can treat diabetes and obesity. X-Phe and N-acetyltaurine.
20..A pre-clinical study to test the ability of their 3D-printed implants to promote the growth of natural tissue and completely degrade over time.
21..A non-invasive bladder cancer urine test, the sixth most common cancer.
22..The first clinical trial of its BV test to differentiate between bacterial and viral infections.
23..A handheld device capable of performing full lung function tests of lungs.
24..Long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function.
25..We constructed the first transcriptomic atlas of immune cells encompassing human lifespan, ranging from newborns to supercentenarians.
26..A human surgeon will at most perform tens of thousands of surgeries in a lifetime. An AI surgeon will be able to learn from millions of surgeries to perfect the procedure. In the future, most surgeries will be done better and faster by AI.
27..In the population of acute myocardial infarction patients, an elevated Aggregate Index of Systemic level is significantly associated with an increased risk of cardiovascular death.
LONG NOTES:
Researchers from Mayo Clinic have found how long a person can stand on one leg is a better measure of aging than changes in strength or gait. In one study led by researchers at Duke Health, adults in their 30s and 40s could balance on one leg for close to one minute. Adults in their 50s were able to stand on one leg for about 45 seconds, and those in their 70s for 26 seconds.
Quercetin Attenuates MRGPRX2-Mediated Mast Cell Degranulation via the MyD88/IKK/NF-κB and PI3K/AKT/ Rac1/Cdc42 Pathway. Quercetin is a promising treatment for allergic diseases.
Roles of Microenvironment on Mesenchymal Stem Cells Therapy for Osteoarthritis
Stem cell therapy is a promising treatment for OA, and mesenchymal stem cells (MSCs) are the main cell sources for this therapy. With multispectral differentiation and immunomodulation, MSCs can effectively regulate the microenvironment of articular cartilage, ameliorate inflammation, promote regeneration of damaged cartilage, and ultimately alleviate OA symptoms. However, the efficacy of MSCs in the treatment of OA is greatly influenced by articular cavity microenvironments. This article reviews the five microenvironments of OA articular cavity, including inflammatory microenvironment, senescence microenvironment, hypoxic microenvironment, high glucose microenvironment and high lipid environment, focus on the positive and negative effects of OA microenvironments on the fate of
Safety Evaluation of a Potential Anti-Rheumatoid Arthritis Candidate, Levamisole.
The results showed that 30 mg/kg LVM has promising therapeutic effects in the treatment of RA with negligible toxicity from 45 mg/kg to 180 mg/kg.
Discussions: This study provides valuable preclinical data on the safety and efficacy of LVM, laying the groundwork for future clinical applications and potentially offering a safer and more effective treatment option for RA
Cyperus rotundus Ameliorates Osteoarthritis: A Work Based on Network Pharmacology. Cyperus rotundus (CR) is widely used in traditional Chinese medicine to prevent and treat a variety of diseases. However, its functions and mechanism of action in osteoarthritis (OA) has not been elucidated. Theoretically, CR has great potential to ameliorate the symptoms and progression of OA, via multiple components, multiple targets, and multiple downstream pathways.
Association of Short Sleep Duration and Obstructive Sleep Apnea (OSA)with Central Obesity: A Retrospective Study. BMI and Waist-to-Height Ratio are significantly associated with OSA and short sleep duration, and might serve as a pote ntial surrogate marker for central obesity.
Link Between Obstructive Sleep Apnea and Kidney Stones: NHANES 2015–2018 and Mendelian Randomization. OSA promotes the formation of kidney stones, and the treatment and management of OSA can improve or mitigate the occurrence of kidney stones.
Impact of Replacing Sedentary Behavior (SB) with Physical Activity (VPA) and Sleep on Stroke Risk: A Prospective Cohort Study. The findings demonstrate that leisure-time SB and unhealthy sleep durations are confirmed risk factors for stroke. For individuals sleeping 8 hours or less per day, and for those who sleep more than 8 hours, substituting SB with an adequate amount of sleep or engaging in VPA, respectively, emerges as an effective strategy for reducing stroke risk.
Causal Relationship Between Childhood Obesity and Sleep Apnea Syndrome: Bidirectional Two-Sample Mendelian Randomization Analysis. There is a causal relationship between genetic susceptibility to childhood obesity and increased risk of sleep apnea syndrome. People with a history of childhood obesity should pay more attention to physical examination to early prevention and management of sleep apnea syndrome.
The study revealed causal associations between sleep duration, sleep-wake disorders, and low grip strength. Causal Associations Between Sleep Traits and Low Grip Strength: A Bidirectional Mendelian Randomization Study
Research regarding the actual age at which a person retires compared to their average life expectancy suggests that delaying retirement for just one year can decrease a person’s mortality rate by 11%. Even though this study examined retirees from different socioeconomic backgrounds, job types, and health statuses, we can’t conclude that retiring a year later actually increases a person’s lifespan. To be able to establish a cause, you’d have to force study participants to retire at particular ages, which wouldn’t be ethical. First, it could be that working keeps your brain sharp and helps prevent cognitive decline that naturally occurs in older adults. Working also may provide a social outlet with colleagues and work peers that help us stay involved and connected. Social isolation is an issue that many adults will experience at an older age.
Inhaling lavender really does inhibit pain receptors to provide relief from pain. Science 25 Oct pg394
The Economist 10/26, pg14-One jab to treat them all! Ozempic reduces brain inflammation likely preventing Alzheimers, decreases heart attacks and strokes, lowers metabolic liver disease, lowers risk of diabetic kidney disease, increases insulin synthesis and secretion. And there are lots more of these drugs being developed that will be much less expensive!
Aging clocks battle for science glory and cash. Science 25 Oct pg 364 – Currently methylation clocks seem most accurate. The Horvath clock uses 353 CpG sites on DNA. The latest version, GrimAge, can predict when people will get heart disease, cancer, and death. There are also proteomic clocks, which measure specific protein levels to estimate physiological age. But they are not ready for clinical use. Doctors should just recommend better diet and more exercise.
Science 25 Oct pg 380 – Vitamin E and selenium supplementation increases the risk for prostate cancer!
Rejuvenate skin with your own cells. Israel’s Ananda Labs is developing an organic treatment that improves skin elasticity, diminishing wrinkles and scars. Using technology of Hebrew University Prof. Yossi Buganim, Ananda genetically reprograms skin cells into placental stem cells, up to 50% younger than the adult originals.
Skin aging, one of the most visible forms of aging, is influenced by both intrinsic and extrinsic factors. The extrinsic ones, such as sunlight exposure, air pollution, and cigarette smoke, are well known. However, the intrinsic ones, such as age-induced hormonal changes, are less well-researched and understood.
On a molecular level, some of the most prominent changes are to the skin’s extracellular matrix (ECM). The ECM is a structure built from such components as collagen, hyaluronic acid (HA), and proteoglycans. During aging, collagen and hyaluronic acid levels decrease. This decrease impacts the integrity of the ECM.
The claim of slowing down skin aging by promoting collagen synthesis is a common feature of cosmetics advertising. However, so far, “no effective agents for preventing or restoring aged skin have been identified.”
While reversing the signs of skin aging has aesthetic value, this study’s authors argue that their research on this topic can be a stepping stone to a better understanding of whole-body aging and therapies to address it.
To investigate skin aging, the researchers used a parabiosis experiment in which two animals are connected following surgery to share the bloodstream. In this experiment, the researchers connected the circulation of young and old animals, along with control groups of connected young animals and connected old animals.
\ The researchers examined the animals’ hyaluronic acid and collagen levels after three weeks after surgery. They observed that the levels of hyaluronic acid of old animals connected to young ones “were almost completely restored.” This treatment also increased newly synthesized collagen and the gene activity of some of the procollagen types in the deep skin (dermis) of old mice connected to the bloodstream of the young mice were also increased compared to the old mice.
The authors suggested that blood-borne factors contribute to the restoration of the dermis in old animals. Therefore, they tested the differences in the composition of proteins in these animals’ plasma. After identifying several differences, they focused on one protein: HAPLN1. The authors note that this protein was not previously linked to aging. However, their investigation suggests a rejuvenating effect of HALPN1 and a possible role in depositing collagen and hyaluronic acid in aged skin.
AI alerts of an impending stroke. More about Israel’s Avertto (see here previously) that has developed the first medical device with an AI alert of an impending stroke based on biological mimicry. Avertto cites studies indicating that 80% of strokes are preventable.
New metabolites can treat diabetes and obesity. Israel’s Metabolize is testing two molecules that reduce both appetite and weight, helping to treat diabetics and the obese. The phenylalanine metabolite X-Phe and N-acetyltaurine (NAT) don’t have the side effects of existing medications and can be ingested rather than injected.
3D-printed implants. (TY Atid-EDI) Israeli startups Collplant and Stratasys have commenced a pre-clinical study to test the ability of their 3D-printed implants (see here previously) to promote the growth of natural tissue and completely degrade over time. It may be an alternative to reconstructive surgery after cancer surgery.
Italy’s Menarini Diagnostics is to distribute the EpiCheck non-invasive bladder cancer urine test from Israel’s Nucleix (see here previously) in Europe. Bladder cancer is the sixth most common cancer as there are approximately 760,000 people in Europe with the disease.
Israel’s MeMed (see here previously) successfully completed the first clinical trial of its BV test to differentiate between bacterial and viral infections. The test on 260 patients with suspected lower respiratory tract infection resulted in a 62% relative reduction in unnecessary antibiotics.
Israel’s TechnoPulm is developing a handheld device capable of performing full lung function tests of lungs. The tool will replace large, expensive machines with a compact, portable device that weighs just 400 grams. It can be operated in the physician’s office and complete the entire test in under three minutes.
Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Partial cellular reprogramming is one of the hottest directions in longevity research for a reason: it allows to rejuvenate cells without driving them all the way to pluripotency, where they lose their identity. One of the ways that partial reprogramming can be achieved is through intermittent administration (“pulsing”) of reprogramming factors. This approach has produced increased lifespan and healthspan in various animal models [2].
The immune system undergoes progressive functional remodeling from
neonatal stages to old age. Therefore, understanding how aging shapes
immune cell function is vital for precise treatment of patients at
different life stages. Here, we constructed the first transcriptomic
atlas of immune cells encompassing human lifespan, ranging from newborns
to supercentenarians,
From Johan Stauland newsletter: I just finished reading Ray Kurzweil’s book The Singularity Is Nearer: When We Merge with AI. To develop a drug or vaccine did in the past take several years. AI will let us develop more effective and precise drugs in a matter of days (or hours) instead of years. The space of physically possible potential drug molecules has been estimated to contain some one million billion billion billion billion billion billion possibilities. AI now enables us to sift through this entire pile in a matter of hours. We can now use AI simulators to design drugs and vaccines in a matter of minutes or hours.AI will be significantly faster and better than human doctors in all diagnostic tasks. A human surgeon will at most perform tens of thousands of surgeries in a lifetime. An AI surgeon will be able to learn from millions of surgeries to perfect the procedure. In the future, most surgeries will be done better and faster by AI.
The Aggregate Index of Systemic Inflammation (AISI) and patients with acute myocardial infarction (AMI). In the population of AMI patients, an elevated AISI level is significantly associated with an increased risk of cardiovascular death and can serve as an early marker for adverse prognosis. Association Between the Aggregate Index of Systemic Inflammation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Retrospective Study.
