SUBJ: Anticancer drugs are predicted to slow aging.
SUBtitle: Live BEYOND 180-Why 180 years? Because we CAN.
Another New paid subscriber to Nutrition Investigator! And I got the notice on Mother’s Day, from a person with the initials JC! Thanks for giving me concrete encouragement.. (Note that reading nutrition information like this once a week is likely to add 7 years of good health to your life.)
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SHORT NOTES:
Anticancer drugs are predicted to slow aging.
Live BEYOND 180-Why 180 years? Because we CAN.
U-shaped association between sleep duration and biological aging.
A natural hallucinogen, ameliorates Alzheimer’s disease.
Contributions to my newsletter include an automatic donation to Stripe.
“The whole plant is a brain.” NPR botanist
Portable screening addresses the leading cause of blindness in the global working population.
How cancer cells prevent being destroyed by the immune system.
An empty OR carries a cost of $1,000 for each unused hour.
My new Mito-C formula is being made with liposomal vitamin C
LONG NOTES:
IF1 Protein Controls Aging Rate. IF1 protein inhibits F1F0 ATP hydrolysis (and not F1F0 ATP synthesis). Across investigated species more IF1 protein, and less F1F0 ATP hydrolysis, correlates with greater maximal lifespan. selective drug inhibition of F1F0 ATP hydrolysis exerts potent anticancer activity. In short, this paper teaches how mammals metabolically generate heat, why different mammal species have different maximal lifespans, and new anticancer drugs, that are predicted to slow aging.
From Fatty15: Live BEYOND 180-Why 180 years? Because we CAN.
The number of biohacking technologies available to help upgrade humanity is astounding. There is so much available to master longevity in a way that’s never been done before. The oldest person to ever live reached 120. With the latest advances in biohacking tech, we can do 50% better than that. At least. 3-Day General Admission
Live BEYOND 180: 3 days full of inspiring keynote speakers, panels, workshops, networking events, nutritious food, and more.
U-shaped association between sleep duration and biological aging: Evidence from the UK Biobank study A UK Biobank study of 241,713 participants shows a U-shaped link between sleep duration and aging. Both short (≤5 hours) and long (≥9 hours) sleep durations correlate with accelerated aging compared to 7 hours, mediated by biomarkers like cystatin C and GGT.
N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk. DMT, a natural psychedelic and Sig-1r agonist, improves cognitive function, reduces Aβ accumulation, and restores Sig-1r levels in 3×TG-AD mice. It enhances ER-mitochondria interactions, calcium dynamics, and mitochondrial function.
Contributions to my newsletter include an automatic donation to Stripe.
Stripe Climate members have contributed to a diverse portfolio of 45 projects.
Direct air capture 30.4%; Enhanced weathering & mineralization 21.7%; Ocean alkalinity enhancement 10.9%; Biomass transformation & sequestration 19.; Storage 10.9%; Direct ocean removal 6.5%
“The whole plant is a brain.” NPR botanist presenting the idea that plants are both conscious and intelligent.
The US FDA has approved the fully autonomous AI from Israel’s AEYE Health (see here previously) that diagnoses referable diabetic retinopathy from retinal images obtained by a handheld camera. Portable screening addresses the leading cause of blindness in the global working population.
How cancer manipulates the immune system. Researchers at Israel’s Bar-Ilan University are the first to analyze biopsies to discover how cancer cells prevent being destroyed by the immune system. As each patient is different, the results will help scientists develop personalized strategies for destroying tumors.
Improving the use of Operating Rooms. Israel’s Opmed.ai has developed an AI optimization platform for healthcare, starting with Operating Rooms. An empty OR carries a cost of $1,000 for each unused hour. Opmed.ai is already used in the US and Israel and is working with leading Health Systems such as Mayo Clinic.
MY NEW MITO-C FORMULATION is being made with liposomal vitamin C. The following notes indicate that liposomal vitamin C has advantages over regular vitamin C. I never thought Estrace had any advantage, but Pureway C does seem more effective.
- A novel vitamin C preparation enhances neurite formation and fibroblast adhesion and reduces xenobiotic-induced T-cell hyperactivation. These data confirm the previous observations that vitamin C supplementation can promote neu- rite outgrowth, increase fibroblast adhesion and reduce xenobiotic induce immunocytes aggrega tion. More importantly, these data show that PureWay-CTM has a faster and greater beneficial ef-fect on these parameters when compared to other vitamin C formulations.
- These data demonstrate that the vitamin C-lipid metabolites (PureWay-CTM) are more rapidly taken-up and absorbed by cells than other forms of vitamin C, including Ester-C®. This increased rate of absorption correlates with an increased protection of the T-lymphocytes from pesticide toxicities. Further, vitamin C-lipid metabolites (PureWay-CTM) are a potent antioxidant and have significant free radical scavenging capabilities.
- PureWay-C® is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C®.
- These data demonstrate that xenobiotic-induced a5b1 integrin mediated T-cell adhesion to fibro- nectin is reduced by nutritional supplementation with Natramune (PDS-2865) and PureWay-C. These data suggest the possibility that inflammatory responses associated with exposure to pollutants can be mitigated by nutritional supplementation.
