SUBJ: stand on one leg for 10 seconds.
SUBtitle: Quercetin Protects (in Mito-C)
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SHORT NOTES:
A 4x higher mortality rate of 51 to 75 year olds who could NOT stand on one leg for 10 seconds.
Quercetin Protects Against a medical emergency that occurs when blood flow to the brain is restricted. Mito-C contains daily dose of quercetin.
Getting up easily in the morning or sleep duration were associated with a higher risk of glaucoma.
Too much weekend sleep duration is linked to health issues, including mortality.
Vitamin K has shown potential for the prevention and treatment of various diseases.
First cell therapy approved by FDA to fight solid tumors.
Chronic fatigue syndrome is real, but complex and difficult to diagnose
Long COVID still is a puzzle. Vaccination reduces rate by 40%. Reinfection can also trigger long COVID.
Strong evidence for the role of resistance exercise to prevent declines in muscle strength and function.
Higher serum GDF11 in lifelong exercising men compared to sedentary peers.
LONG NOTES:
This study found a 4x higher mortality rate over just 7 years among the 20% of 51 to 75 year olds who could NOT stand on one leg for 10 seconds… Here is the study:
https://bjsm.bmj.com/content/56/17/975
Quercetin Protects Against Global Cerebral ischemia‒reperfusion Injury by Inhibiting Microglial Activation and Polarization. Global cerebral ischemia is a medical emergency that occurs when blood flow to the brain is restricted. This study highlights the novel therapeutic potential of quercetin in alleviating GCI/R injury. Quercetin demonstrates its neuroprotective effects by inhibiting neuroinflammation and microglial activation while impeding their transformation into the M1 phenotype through modulation of the TLR4/TRIF pathway.
Although previous studies of sleep-related behaviors in relation to primary open-angle glaucoma (POAG) have been noted, the causal relationship remains unclear. Our study demonstrated that genetic prediction of getting up easily in the morning or sleep duration were associated with a higher risk of POAG, but not vice versa, in a European population.
Weekend sleep duration is linked to health issues, including mortality. The underlying mediators of long weekend sleep duration (lWD) and chronic kidney disease (CKD) could be the dysregulation of human behaviors, metabolism, or biological functions. Longer weekend sleep duration was linked to a decrease in eGFR levels, which may indicate that your kidneys aren’t working properly..
Vitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature in the form of VK1 and VK2. As its initial recognition originated from the ability to promote blood coagulation, it is known as the coagulation vitamin. However, based on extensive research, VK has shown potential for the prevention and treatment of various diseases. Studies demonstrating the beneficial effects of VK on immunity, antioxidant capacity, intestinal microbiota regulation, epithelial development, and bone protection have drawn growing interest in recent years
Science 23 Feb pg 800-First cell therapy approved by FDA to fight solid tumors, esp. melanoma. Pg 801-Obesity drugs like GLP-1 cut cravings for opiates. Pg 804-Chronic fatigue syndrome is real, but complex and difficult to diagnose. “The patient population is desperate.” Pg 830 – Long COVID still is a puzzle. Vaccination reduces rate by 40%. Reinfection can also trigger long COVID. In 2022, 6.9% of adults ever had Long COVID and 3.4% of adults currently had Long COVID.
Obstacles to the Early Diagnosis and Management of Sarcopenia: Current Perspectives. Research in sarcopenia has grown exponentially over the last 15 years in geriatrics and gerontology, as well as other specialties, including oncology and hepatology. There is now strong evidence for the role of resistance exercise to prevent declines in muscle strength and function, especially when combined with nutritional optimization with protein supplementation. This includes our recommendation of incorporation of handgrip strength measurement into standard care, to enable dynamic assessment and identification of early declines in handgrip strength, so that interventions can be implemented to prevent disability.
In our report, physical fitness correlated with GDF11 levels in serum, which is in line with results of a previous study reporting higher serum GDF11 in lifelong exercising men compared to their lifelong sedentary peers (19). It seems therefore plausible to speculate that physical fitness not only determines the tissue-specific expression and concentration of GDF11, but also the magnitude of its exercise-stimulated regulation.
