SUBJ: Lifespan-extending compounds in animals may not help humans
SUBtitle: Effective obesity treatments exist for the first time
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SHORT NOTES: Caution should be used when making assumptions about the translatability of lifespan-extending compounds across species; We are entering an era in which effective obesity treatments exist for the first time; More evidence to support use of Mito-C: In Alzheimers disease tau protein misfolds and forms oligomers, which clump together; Prenatal carotenoid supplementation significantly increased maternal and infant systemic (skin and serum) carotenoid status; Higher intake of fiber is associated with reduced inflammatory bowel disease; Higher Adherence to Cardioprotective Diet is Associated with Reduced Risk of Enterotomy and All-Cause. An unfavorable association with mortality is observed for low-carbohydrate intake in men and for high-carbohydrate intake in women; Sarcopenia is a common disease in the elderly, and the thyroid hormone (TH) participates in the pathogenesis of sarcopenia; ; Resistance exercise training (RET) can counteract negative features of muscle ageing; changes in epigenetic methylation with aging linked obesity to getting old; best to eat as you age: fiber, whole grains, nuts, .; how to lose weight after menopause
LONG NOTES:
Science 4 Aug pg 463-Turning the tide on obesity: We are entering an era in which effective obesity treatments exist for the first time.
Science 28 July pg 377-More evidence to support use of Mito-C: In Alzheimers disease and other tauopathies, tau protein misfolds and forms oligomers, which clump together to form filamentous aggregates. Mito-C is designed to reduce protein misfolding.
J Nutr Aug: Prenatal carotenoid supplementation significantly increased maternal and infant systemic (skin and serum) carotenoid status, which may benefit pregnant women and their infants’ health.
Higher intake of fiber is associated with reduced inflammatory bowel disease-related surgery risk in patients with inflammatory bowel disease with Crohn disease but not ulcerative colitis .
Higher Adherence to Cardioprotective Diet is Associated with Reduced Risk of Enterotomy and All-Cause Mortality among 5549 Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study. Cardioprotective diet scores (range 0–7) were calculated based on the consumption of 7 common food groups collected by a validated food frequency questionnaire.
An unfavorable association with mortality is observed for low-carbohydrate intake in men and for high-carbohydrate intake in women. High fat intake can be associated with a lower mortality risk in women among Japanese adults with a relatively high-carbohydrate intake.
Clinical Interventions in Aging: Sarcopenia is a common disease in the elderly, and the thyroid hormone (TH) participates in the pathogenesis of sarcopenia.There is an association between the low TT3 level and sarcopenia. Therefore, maintaining higher T3 concentrations within the normal range appears to be beneficial for sarcopenia in the elderly. Older muscle is characterised by RET-induced metabolic protein profiles that, whilst not present in younger muscle, improve untrained age-related proteomic deficits.
Using published data sources, we identify only modest sensitivity and specificity of Drosophila interventional studies for identifying pro-longevity compounds in mouse lifespan studies. Surprisingly, reported studies in C. elegans show little predictive value for identifying drugs that extend lifespan in mice. The results therefore suggest caution should be used when making assumptions about the translatability of lifespan-extending compounds across species, including human intervention.
Geroscience:Resistance exercise training (RET) can counteract negative features of muscle ageing but older age associates with reduced adaptive capacity to RET. Altered muscle protein networks likely contribute to ageing RET adaptation; therefore, associated proteome-wide responses warrant exploration.
Universal DNA methylation age across mammalian tissues If I understand correctly, the authors seemed to think changes in epigenetic methylation with aging linked obesity to getting old.
WebMD-best to eat as you age: fiber, whole grains, nuts, water, fish, protein in “real” food like eggs, lean meat, and dairy products, blueberries, red and orange produce, cruciferous veggies, dark leafy greens, avocado, sweet potato.
WebMD-how to lose weight after menopause: Use the USDA’s MyPlate Plan to figure out how many calories you need daily based on your age, gender, height, weight, and activity level. Choose fruits, vegetables, whole grains, lean proteins, and healthy (olive and vegetable) oils. Avoid carbs like bread, pasta, and baked goods, which are harder to burn off. Steer clear of calorie-filled alcohol, sodas, and coffee drinks too. Aim for at least 2.5 hours a week of moderate aerobic exercise. If you’ve checked all the boxes of diet and exercise, and still aren’t seeing any changes, talk with your doctor. Even if it’s just for a week or two, write down everything you eat and drink daily. This will give you a clear picture of places you can cut back if the weight won’t come off. Jot down your exercise too. A solid night of sleep is always good for your body.
