SUBJ: Cholesterol levels do not affect risk of heart disease
SUBtitle: Statins with hazardous side effects lower cholesterol levels but not the risk of heart disease
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SHORT NOTES: cholesterol levels are unrelated to risk of heart disease; statins do not reduce the risk of heart attacks, and that statins have many harmful side effects; The Common Sweetener Sucralose May Accelerate Aging; Delta tocotrienils are best taken at night to lower cholesterol [but cholesterol does not matter!]; long-lasting memories are consolidated during sleep by communication between the hippocampus and the cerebral cortex; Gut Microbiota and Aging: Traditional Chinese Medicine and Modern Medicine; Cartilage regenerates and inflammation modulates in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells; Acarbose Mitigates Age-Dependent Alterations in Erythrocyte Membrane Transporters During aging; BMI is no longer considered valid; Alzheimer’s is triggered by a few initial molecules. This justifies taking Mito-C starting when you are young, like 30!
LONG NOTES:
I just spoke to a cardiologist alum of Carleton College Dr. Dubroff, who sent me topic medical journal articles he has written the past few years showing that cholesterol levels are unrelated to risk of heart disease, that statins do not reduce the risk of heart attacks, and that statins have many harmful side effects that increase the risk of heart disease, cancer, depression, and more. I encourage you to read these and bring them to your physicians.
You may be old enough to recall when ulcers were caused by stress, and we should just learn to relax. It took 20 years before medicine accepted the discovery that ulcers are caused by a bacterial infection that can be cured by antibiotics, or peptobismol!
Today we are learning that heart disease risk can be reduced by lifestyle change – diet and exercise – NOT by statins, whose use just benefits pharmaceutical companies. Here is the new evidence. Links are to published medical journal articles:
- Over the past 10 years cholesterol levels have been falling while the number of Americans dying of heart disease has been steadily climbing. This apparent paradox compels us to question whether lowering cholesterol is the best way to prevent coronary heart disease.
- Cholesterol Paradox: a correlate does not a surrogate make: The global campaign to lower cholesterol by diet and drugs has failed to thwart the developing pandemic of coronary heart disease around the world. Some experts believe this failure is due to the explosive rise in obesity and diabetes, but it is equally plausible that the cholesterol hypothesis, which posits that lowering cholesterol prevents cardiovascular disease, is incorrect. The recently presented ACCELERATE trial dumbfounded many experts by failing to demonstrate any cardiovascular benefit of evacetrapib despite dramatically lowering low-density lipoprotein cholesterol and raising high- density lipoprotein cholesterol in high-risk patients with coronary disease. This clinical trial adds to a growing volume of knowledge that challenges the validity of the cholesterol hypothesis and the utility of cholesterol as a surrogate end point. Inadvertently, the cholesterol hypothesis may have even contributed to this pandemic.
- Fat or fiction: the diet- heart hypothesis -The preponderance of evidence indicates that low-fat diets that reduce serum cholesterol do not reduce cardiovascular events or mortality. Specifically, diets that replace saturated fat with polyunsaturated fat do not convincingly reduce cardiovascular events or mortality. These conclusions stand in contrast to current testimony to the contrary, a behaviour called confirmation bias. Others have noted the limitations of targeting a single risk factor potentially lead to heart disease. There are several possible explanations. Foremost, we must consider that the diet-heart hypothesis is invalid or requires modification. Moreover, some experts may selectively cite evidence that validates their own viewpoint while disregarding evidence-based medicine opinion and debate.
Over the past 10 years cholesterol levels have been falling while the number of Americans dying of heart disease has been steadily climbing. This apparent paradox compels us to question whether lowering cholesterol is the best way to prevent coronary heart disease. A number of recent studies suggest that cholesterol, specifically LDL- C, may not be a primary risk factor for coronary heart disease and other markers, such as insulin resistance or remnant cholesterol, may be much more important. Furthermore, therapies designed to prevent coronary heart disease by lowering cholesterol with drugs or diet have yielded inconsistent results. Despite the widespread utilization of cholesterol-lowering statins in Europe, observational studies indicate that there has been no accompanying decline in coronary heart disease deaths. This new evidence should give us pause as we try to understand why the campaign to prevent heart disease by lowering cholesterol has not achieved its goals.
- The Fallacy of OTC Statin Therapy – The report by Nissen et al (1) confirms that consumers eligible for nonprescription rosuvastatin therapy can be reliably identified through technology-assisted self-selection. Whether over- the-counter statin therapy for primary prevention would positively affect public health is debatable. We already have an over-the-counter preventive therapy for cardiovascular disease that is highly effective, widely available, and has no risk. It is called a healthy lifestyle and was completely ignored in this paper. The simplicity of taking a statin pill is likely to fuel patients’ complacency about being “protected” from heart disease, at the expense of engaging in more protective lifestyle interventions.
- The health risk to you from taking a statin– Muscle Pain and Weakness, neuropathy, heart failure, dizziness, cognitive impairment, cancer, pancreatitis, and depression.
The Common Sweetener Sucralose May Accelerate Aging
Delta tocotrienils best taken at night to lower cholesterol [but cholesterol does not matter!] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435257/
The power of sleep. Researchers at Tel Aviv University and UCLA have shown that long-lasting memories are consolidated during sleep by communication between the hippocampus and the cerebral cortex. Deep-brain stimulation during sleep improves memory consolidation and provides hope for dementia patients.
Delta tocotrienils best taken at night to lower cholesterol [but cholesterol does not matter!] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435257/
The power of sleep. Researchers at Tel Aviv University and UCLA have shown that long-lasting memories are consolidated during sleep by communication between the hippocampus and the cerebral cortex. Deep-brain stimulation during sleep improves memory consolidation and provides hope for dementia patients.
Gut Microbiota and Aging: Traditional Chinese Medicine and Modern Medicine. While analysing the relationship between gut microbiota and aging, this review explores the similarities and differences in treatment methods and mechanisms between TCM and Modern Medicine, in order to explore a new approach that combines TCM and Modern Medicine to regulate gut microbiota, improve immunity and delay aging.
Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial (2023) Intra-articular injection of mesenchymal stromal cells (MSCs) with immunomodulatory features and their paracrine secretion of regenerative factors proposed a noninvasive therapeutic modality for cartilage regeneration in knee osteoarthritis (KOA). Inter-articular injection of AD-MSCs in patients with KOA is safe. Laboratory data, MRI findings, and clinical examination of patients at different time points showed notable articular cartilage regeneration and significant improvement in the treatment group.
Acarbose Mitigates Age-Dependent Alteration in Erythrocyte Membrane Transporters During Aging in Rats 2023
Acarbose (ACA), a well-studied and effective inhibitor of α-amylase and α-glucosidase, is a postprandial-acting antidiabetic medicine. The membrane of the erythrocyte is an excellent tool for analyzing different physiological and biochemical activities since it experiences a range of metabolic alterations throughout aging.
NPR-BMI is no longer considered valid – need other information to decide if you are overweight or have health risks besides body weight and height.
NPR – Alzheimer’s is triggered by a few initial molecules. These set off an avalanche of others before harm is detected. To prevent brain disorders like Alzheimers and Parkinsons, you must prevent those initial harmful molecules from forming. This justifies taking Mito-C starting when you are young, like 30!
