SUBJ: Curcumin supplementation significantly reduced BMI, BW, and WC
SUBtitle: Almond consumption has a beneficial effect on inflammatory markers
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SHORT NOTES: Curcumin supplementation significantly reduced BMI, BW, and WC; Almond consumption has a beneficial effect on inflammatory markers; Plant-Based Meat Alternatives Can Help Facilitate and Maintain a Lower Animal to Plant Protein Intake Ratio; the effect of increasing physical activity on total energy expenditure will be mostly additive; Twenty-first-century nutrition science is aimed at better understanding the increasingly appreciated bioactive substances within the food matrix that help regulate our microbiome and mitochondria; consumption of nuts and reduced intake of fructose, red meat, and alcohol were associated with a lower risk of pancreatic cancer; fiber supplementation could contribute to the management of dyslipidemia and the reduction of cardiovascular disease risk; Clinical practice guidelines (CPGs) provide recommendations to clinicians based on current medical knowledge to guide and reduce variability in clinical care; when you retire, combining energy restriction with mixed exercise and high protein may prevent sarcopenic obesity; Low urine output and dehydration are the common risks of all kidney stone types, whereas hypercalciuria, hyperoxaluria, and hypocitraturia are the major risks of calcium stones; stem cells have been created that do not trigger an immune response from an immunologically incompatible donor. Important review of the healthy longevity methods of glycine supplementation; ketone body supplementation appears to benefit young and old mice but not middle age ones; skin lotion treatment costs $150 for a jar of the lotion, but it might be interesting to try to slow down skin senescence; wake up and go to sleep at the same times; Schizophrenia treatment gets US approval; The 15-min BV test accurately diagnosed over 90% of bacterial versus viral infections; precision microbiome oncology therapeutics counter anti-biotic resistance, reduce chemotherapy side-effects and tackle gut inflammation; an ultrasound technology has won two recent international awards, Noninvasive Cellulite Treatment and Best Anti-Aging Pro Treatment.
LONG NOTES:
AJCNMay-; Curcumin supplementation significantly reduced BMI, BW, and WC. Augmenting curcumin supplement with lifestyle modification should be an option for weight reduction; Although the importance of LCPUFAs in preterm health is accepted, how to best deliver and replete LCPUFAs to avoid postnatal deficits and their downstream consequences remains elusive. The authors’ conclusions that DHA alone may be harmful and that DHA+AA is potentially beneficial are supported by prior human and animal studies [11, 12]; Fish oil supplementation of mothers with overweight or obesity during pregnancy did not impact infant body composition; Calorie-restricted diets may be effective intervention for type 2 diabetes remission, especially when coupled with an intensive lifestyle modification program
AdvNutMay- Almond consumption has a beneficial effect on inflammatory marker CRP and IL-6 concentrations in adults.
Plant-Based Meat Alternatives Can Help Facilitate and Maintain a Lower Animal to Plant Protein Intake Ratio. Whether existing PBMAs provide similar health benefits as whole legumes, or can be formulated to do so, remains to be established;
The idea that increasing physical activity directly adds to TEE (total energy expenditure) in humans (additive model) has been challenged by the energy constrained hypothesis (constrained model). This model proposes that increased physical activity decreases other components of metabolism to constrain TEE. The available evidence indicates that in many scenarios, the effect of increasing physical activity on TEE will be mostly additive although some energy appears to “go missing” and is currently unaccounted for;
The twentieth century nutrition science focused on decoding the processes and building blocks of this transformation—proteins, fats, carbohydrates, vitamins, and minerals. Twenty-first-century nutrition science is aimed at better understanding the increasingly appreciated bioactive substances within the food matrix that help regulate this transformation—fibers, phytonutrients, bioactive fats, and ferments. Our microbiome and the mitochondria play a key function in orchestrating the role of bioactives in health and are inspiring next-generation nutritional approaches for addressing over- and undernutrition. Processing of grains to create white wheat and rice has helped address food insecurity by improving shelf stability and cost of goods, but it has also removed the nutrient- and bioactive-rich bran and germ. In addition, the increase in ultraprocessed foods in both low- and high-income countries has further depleted and disrupted the balance of nutrients, which has been linked to diseases of overnutrition and the double burden of malnutrition;
The health effects of dairy products are still a matter of scientific debate owing to inconsistent findings across trials. In conclusion, our findings indicate that there is little robust evidence that a higher dairy intake has detrimental effects on markers of cardiometabolic health;
This umbrella review found that regular consumption of nuts and reduced intake of fructose, red meat, and alcohol were associated with a lower risk of pancreatic cancer; results suggest that soluble fiber supplementation could contribute to the management of dyslipidemia and the reduction of cardiovascular disease risk;
Clinical practice guidelines (CPGs) provide recommendations to clinicians based on current medical knowledge to guide and reduce variability in clinical care. were most closely aligned in promoting consumption of major plant food groups (vegetables = 74% of CPGs, fruit = 69%, whole grains = 58%), whereas discouraging intake of alcohol (62%) and salt or sodium (56%). CVD and diabetes CPGs were similarly aligned with additional messaging to consume legumes/pulses (60% of CVD CPGs; 75%, diabetes), nuts and seeds (67%, CVD), and low-fat dairy (60%, CVD). Diabetes guidelines discouraged sweets/added sugars (67%) and sweetened beverages (58%). This alignment across CPGs should boost clinician confidence in relaying such dietary guidance to patients in accordance with their relevant CPGs.
The retirement phase is an opportunity to integrate healthy (nutrition/exercise) habits into daily life. Overall, the most effective strategy for nearly all outcomes was combining energy restriction with resistance training or mixed exercise and high protein. Health care professionals involved in the management of persons with obesity need to be aware that an energy-restricted diet alone may contribute to sarcopenic obesity in persons near retirement age.
How to avoid Kidney stone disease (KSD) (alternatively nephrolithiasis or urolithiasis), a global health care problem. Low urine output and dehydration are the common risks of all stone types, whereas hypercalciuria, hyperoxaluria, and hypocitraturia are the major risks of calcium stones. Lots more details how to avoid stones.
Researchers at Sana Biotechnology, Inc., in California, have made a significant breakthrough in realizing the promise of stem cell therapy: stem cells that do not trigger an immune response from an immunologically incompatible donor.
Important review of the healthy longevity methods of glycine supplementation.
• The simple amino acid glycine extends lifespan in worms, mice, and rats.
• Glycine also improves aspects of health in mammalian models of age-related disease.
• Glycine is the acceptor for GNMT, an enzyme responsible for methionine clearance.
• GNMT also converts glycine to sarcosine, an autophagy-inducing metabolite.
• Glycine may prolong life by inducing autophagy and mimicking methionine restriction.
Pros and cons of ketone body supplementation. It appears to benefit young and old mice but not middle age ones.
This skin lotion treatment costs $150 for a jar of the lotion, but it might be interesting to try. A recent study investigated the potential of rapamycin to slow down skin senescence when applied topically as a cream. Patients who underwent the treatment exhibited a significant reduction in senescence markers. The study found that the treatment either prevented cells from entering senescence or increased the clearance of senescent cells.
Sleep advice webmd – wake up and go to sleep at the same times
Schizophrenia treatment gets US approval. The US FDA has approved UZEDY (risperidone), developed for the treatment of schizophrenia by Israel’s Teva and France’s Medincell. In a Phase 3 human clinical trial, UZEDY demonstrated up to 80% reduction in risk of schizophrenia relapse versus a placebo.
The 15-min BV test from Israel’s MeMed (see here previously) accurately diagnosed over 90% of bacterial versus viral infections at Israel’s Schneider Children’s Medical Center, reducing Emergency Department physician error.
Israel’s Trobix Bio is using CRISPR, phage, and synthetic biology technologies to develop precision microbiome oncology therapeutics. TBX101 counters anti-biotic resistance; TBX201 reduces chemotherapy side-effects; TBX301 tackles gut inflammation.
Israel’s SofWave Medical (an ultrasound technology) has won two recent international awards. At the 13th Annual NewBeauty Awards it won Best Noninvasive Cellulite Treatment. Then it won the Good Housekeeping Magazine Award for Best Anti-Aging Pro Treatment.
