SUBJ: Grapes have many health benefits
SUBtitle: A balanced view on pros and cons of metformin
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SHORT NOTES: Grapes have many health benefits; metformin helps influenza vaccine effectiveness; A balanced view on pros and cons of metformin; a high-protein diet, without any exercise, causes insulin resistance and an accumulation of white adipose; ketone body supplementation may represent a double-edged sword with respect to survival; brain disorders from proteinopathies affect between 50% and 99% of humans aged 80; Dietary restriction/fasting modulate all nine hallmarks of aging; There is an association of Alzheimer’s Disease and Hypertension; cryoablation system treated 42 women with the chronic, painful, incurable disease endometriosis; 5 factors to healthy aging. Energized cells, good arteries, removal of old cells, SIRT6 prevents frailty, and methylation counters stress.
LONG NOTES:
Grape benefits: Grapes can have many health benefits. These include: 1. antioxidant, antimicrobial, anti-inflammatory, anti-carcinogenic properties, 2. Lower blood pressure, 3. Prevent heart disease, 4. Help with immune system function , 5. Offer antioxidant and anti-inflammatory properties, 6. Cancer prevention, 7. Diabetes management, 8. Improve sleep quality, 9. Protect against Alzheimer’s disease, 10. Protect bone health, 11. Eye health, 12. Memory, mood, and attention, 13. Protection against bacteria and fungi.
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial. Pre-vaccination metformin treatment improved some components of flu vaccine responses and reduced some markers of T cell exhaustion without serious adverse events in nondiabetic older adults. Thus, our findings highlight the potential utility of metformin to improve flu vaccine responses and reduce age-related immune exhaustion in older adults, providing improved immunological resilience in nondiabetic older adults.
Balanced view on my metformin headline:“Metformin shortens lifespan after 10 years of use” could be misleading and potentially dangerous. It caught my eye because of numerous ads I’ve seen on the Web, likely advertising bogus supplements. “Doctor says throw out your metformin now!” After reading the original research article you cited, I have a few conclusions:
-The term “matched controls” is misleading. It might be impossible to have an adequate control group, because people with diabetes severe enough to require drug treatment need that drug treatment. (Assuming that they cannot resolve their diabetes through diet & exercise, which is rarely possible at that stage.) Comparing diabetics on metformin to non-diabetics is comparing “apples to oranges.” The authors state, “Potential controls were all individuals who were not diagnosed with any form of diabetes.” I assume heart patients on heart medicine, on average, don’t live as long as people without heart disease. Surprise, surprise. -They should have stated their conclusion as something like, “Diabetics taking metformin do not live longer than non-diabetics.”-My concern is that people will read such headlines and decide to quit taking their drugs and will suffer badly for that decision.-My concern also stems from an acquaintance who was trying to convince her diabetic husband (with horrible blood sugar numbers) to quit metformin, possibly from seeing those scary internet ads I mentioned.
Is a high-protein diet still beneficial in the absence of any resistance-type exercise? Recent evidence from the world-leading laboratory of Professor Dudley Lamming at the University of Wisconsin-Madison has shown a high-protein diet, without any exercise, causes insulin resistance and an accumulation of white adipose tissue in as little as 18 weeks, even when matched for caloric intake. Dr. Ryan Marshall discusses these provocative findings, their mechanisms, and how to prevent them.
A GRG person commented: Perhaps this is one reason why my immune system remains in stellar condition at age 85.2. endogenous ketogenesis affects mammalian survival, and ketone body supplementation may represent a double-edged sword with respect to survival, depending on the method of administration and health status.
The unique neuropathological vulnerability of the human brain to aging
• Several proteinopathies uniquely converge in human brain aging.
• The prevalence of brain disorders affects between 50% and 99% of humans aged 80, depending on the proteinopathy.
• Proteinopathies may progress following cell-to-cell transmission and specific cell vulnerability. (My Mito-C supplement is designed to reduce proteinopathies.)
The role of dietary strategies in the modulation of hallmarks of aging
Highlights • Dietary restriction/fasting modulate all nine hallmarks of aging. • Dietary restriction/fasting are the most promising strategies on longevity. • Plant-based diets are an alternative to mimic caloric restriction in humans. • Some positive modulations arise from a Ketogenic diet in preclinical
models.
Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population. A growing volume of published literature on a parallel elevation of blood pressure (BP), amyloid plaques, and neurofibrillary tangles formation in post-middle of human brain cells has developed new, widely accepting foundations on this association.
A study used the cryoablation system from Israel’s IceCure Medical (see here previously) to treat 42 women with the chronic, painful, incurable disease endometriosis. 93.75% had no pain after six months, and 82.72% remained pain-free up to three years later.
The Longevity Nation conference, (Movement for Longevity and Quality of Life in Israel) in March highlighted 5 factors to healthy aging. Energized cells, good arteries, removal of old cells, SIRT6 prevents frailty, and methylation counters stress.
