SUBJ: Physical activity is associated with slower epigenetic ageing
SUBtitle: Positive Health Outcomes Associated with Live Microbe Intake from Foods
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SHORT NOTES: Physical activity is associated with slower epigenetic ageing; Positive Health Outcomes Associated with Live Microbe Intake from Foods; Students taking 8am classes had poorer attendance, reduced sleep, and poorer grades; Engineered bacteria likely to cure melanoma!; Taking supplemental NAD+ (and probably niacin) reduces damage to kidneys from infections, drugs, and toxins; stress damages the gut and microbiota and the diet relieves stress injury by supplementing intestinal microflora; Maternal Diet Quality During Pregnancy and Offspring Hepatic Fat in Early Childhood: The Healthy Start Study; Ginseng raises hazard of some cancers; Rapamycin’s Role-aging is not a result of cellular decline or damage accumulation, but rather an overactive state of cellular metabolism; Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight; why bacon, eggs and coffee can be good for you; Hyperbaric oxygen therapy (HBOT) is effective for relieving fibromyalgia.
LONG NOTES:
Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study. In this study, we examined the relation between physical activity and epigenetic ageing in 3567 eligible participants of a large community-based, prospective cohort study. We show that physical activity is associated with slower epigenetic ageing which was in part mediated by cardiovascular health and immune function. Epigenetic ageing, i.e., age-associated changes in DNA methylation patterns, is a sensitive marker of biological ageing, a major determinant of morbidity and functional decline. We examined the association of physical activity with epigenetic ageing and the role of immune function and cardiovascular risk factors in mediating this relation. After adjustment for age, sex, season, education, smoking, cell proportions and batch effects, physical activity (step counts, MET-Hours and %time spend in moderate-to-vigorous activities) was non-linearly associated with slower epigenetic ageing, in part through its beneficial effects on immune function and cardiovascular health.
JN Apr 23- Positive Health Outcomes Associated with Live Microbe Intake from Foods, Including Fermented Foods (e.g. sauerkraut, yogurt, kefir), Assessed using the NHANES Database. To our knowledge, this study is the first to quantify, in a nationally representative data set of American adults and using stable sets of covariates in the regression models, the adjusted associations of dietary intakes of live microbes with a variety of outcomes, such as anthropometric measures, biomarkers, and blood pressure levels. Our findings suggest that foods with higher microbial concentrations are associated with modest health improvements across a range of outcomes.
Sci 14 Apr pg 170 – Early bird might fail the grade. Students taking 8am classes had poorer attendance, reduced sleep, and poorer grades. This suggests students should avoid 8am classes.
Sci 14 Apr pg 168 – Engineered bacteria likely to cure melanoma! A skin bacterium has been engineered so that it will detect cancerous melanoma cells and then induce an immune response to reject established tumors.
Sci 14 Apr pg 169- Taking supplemental NAD+ (and probably niacin) reduces damage to kidneys from infections, drugs, and toxins. It also promotes recovery of the kidneys.
JN Apr 23-Understanding the Connection between Gut Homeostasis and Psychological Stress. Dietary intake of probiotics can provide energy for intestinal stem cells through glycolysis, thereby alleviating the disruption to homeostasis caused by stress, and it significantly bolsters the intestinal barrier, alleviates intestinal inflammation, and maintains endocrine homeostasis. This article reviews recent research on how stress damages the gut and microbiota, how the gut microbiota can improve gut health by modulating injury due to stress, and how the diet relieves stress injury by interfering with intestinal microflora.
JN Apr 23 –Ginseng raises hazard of some cancers. Short-term (<3 years) ginseng use was found to be significantly associated with increased risk of liver cancer. long-term (≥3 years) ginseng use was found to be associated with increased risk of thyroid cancer (HR = 1.40; 95% CI: 1.02, 1.91; P = 0.036). Long-term ginseng use was found to be significantly associated with decreased risk of lymphatic and hematopoietic tissue malignancy
Rapamycin’s Role as a Molecular Brake for Cellular Hyperfunction and Runaway Cells. “Mikhail Blagosklonny’s theory of cellular hyperfunction has shifted our understanding of aging by proposing that it’s not a result of cellular decline or damage accumulation, but rather an overactive state of cellular metabolism. This idea challenges conventional wisdom and suggests that aging is a reversible phenomenon that can potentially be slowed down or even reversed. This shift in understanding has significant implications for how we approach the aging process.”
New research finds one of the mechanisms of metformin’s benefits. Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight
Bacon, eggs and coffee – 25 g of extra protein daily linked to 14% lower risk of hip fracture, extra cup of coffee reduced risk another 4%.
HBOT is effective for fibromyalgia. Tel Aviv University researchers have found that hyperbaric oxygen therapy (HBOT) is more effective than medication in reducing fibromyalgia pain caused by a traumatic head injury. 40% of the HBOT group were cured of fibromyalgia, compared to none receiving standard medication.
Biological age is increased by stress and restored upon recovery. Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. At epigenetic, transcriptomic, and metabolomic levels, we find that the biological age of young mice is increased by heterochronic parabiosis and restored following surgical detachment.
