SUBJ: Acarbose in an NIH clinical trial contributed to weight loss
SUBtitle: Calorie restriction had less than 3% benefit
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SHORT NOTES: Acarbose in an NIH clinical trial contributed to weight loss; Calorie restriction had less than 3% benefit; a blog by my former student, retired physician with health related essays; Hyperbaric oxygen is hazardous; Exercise in the morning but not in the evening increased breakdown of fat in body; The effects of higher and lower intakes of total meat and meat subtypes on the gut microbiota composition; This review highlights potential gut-related health-beneficial effects of carotenoids; There is emerging evidence of associations between intake of sugar-sweetened beverages (SSBs), those that include various forms of added sugar, and increased risk of cardiovascular disease (CVD), but fructose from eating fruit is beneficial; intervention studies support a causal effect of dairy intake on sleep; Hyperbaric oxygen appears hazardous; The health-promoting effects of exercise including changes in DNA methylation; consider using higher dose melatonin to combat neurological aging decline.- Roc has been taking 5 mg of melatonin four times a week since the quality of life in knee osteoarthritis patients; Start Your Day With Whole Grains! The video recording of the Linus Pauling webinar is now up on YouTube where the expert states she takes 500mg vitamin C twice a day, the optimum dosage discovered by Roc in 1994.
LONG NOTES:
| Calorie restriction slows pace of aging in human trial-An ongoing trial that is studying the effects of consuming fewer calories on aging found a two to three percent reduction in the pace of aging among healthy men and women who followed calorie restricted diets. |
https://decipheryourhealth.com/blog/ is a blog by my former student now retired physician Karin Molander who has a lot of interesting health related essays.
Acarbose in an NIH clinical trial contributed to weight loss. It works by blocking an enzyme called alpha-glucosidase, which helps digest and absorb carbohydrates in the small intestine. By inhibiting this enzyme, acarbose slows down the digestion and absorption of carbs, which can help regulate blood sugar levels and prevent spikes in blood glucose.
Even at just 30%, excess oxygen may increase mitochondrial damage and rate of aging. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Something to consider when choosing anti-aging therapies such as HBOT with 100% oxygen.
Science 10 Mar pg994-Exercise in the morning but not in the evening increased breakdown of fat in body.
Adv Nut- Here is the systematic review to assess the effects of higher and lower intakes of total meat and meat subtypes on the gut microbiota composition. The bacterial composition was differentially affected by consuming diets with and without meat or with varied meat subtypes. For example, higher meat intake tended to decrease population sizes of genera Anerostipes and Faecalibacterium, but it increased the population size of Roseburia across studies. Faecalibacterium and Roseburia are good for you,
Carotenoids have been related to a number of health benefits. Their dietary intake and circulating levels have been associated with a reduced incidence of obesity, diabetes, certain types of cancer, and even lower total mortality. Their potential interaction with the gut microbiota (GM) has been generally overlooked. Carotenoids may further contribute to mucosal and gut barrier health, such as stabilizing tight junctions. This review highlights potential gut-related health-beneficial effects of carotenoids.
There is emerging evidence of associations between intake of sugar-sweetened beverages (SSBs), those that include various forms of added sugar, and increased risk of cardiovascular disease (CVD). All these relationships were linear except for fruit, which was J-shaped: CVD morbidity was the lowest at 200 g/d and there was no protective association above 400 g/d. These findings indicate that the adverse associations between SSBs and CVD, CHD, and stroke morbidity and mortality do not extend to other dietary sources of fructose. So fructose from eating fruit is beneficial.
Poor sleep quality and insufficient sleep affect a large portion of the population. This is concerning given increasing evidence that poor sleep health is a behavioral risk factor for the development of cardiometabolic diseases. Available epidemiologic studies illustrate positive associations between dairy intake and sleep outcomes. Moreover, some intervention studies support a causal effect of dairy intake on sleep.
Many at GRG have advocated sitting in a hyperbaric oxygen chamber to prolong healthspan. That appears to be very dangerous. Even at just 30%, excess oxygen may increase mitochondrial damage and rate of aging. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.
[GRG] No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging-Physiological fitness Study shows “there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length”.- However, for me the main take home message of the study is this finding: “The health-promoting effects of exercise are well documented (Hortobágyi et al. 2022; Quan et al. 2020; Radak et al. 2013), and this study also demonstrates that these changes could be associated with DNA methylation.” [GRG] I urge all aged GRGers to strongly consider using higher dose melatonin to combat neurological aging decline. Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases. We summarize the current knowledge on molecular and circadian regulatory mechanisms of melatonin to overcome neurodegenerative diseases (NDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and amyotrophic lateral sclerosis. [I have been taking 5 mg of melatonin four times a week since the 1980s. An AGE conference presentation reported that, based on gene-expression screening, melatonin turns on many youthful genes and turns off many aging genes.A clinical trial with metformin for knee osteoarthritis. Our findings support the possible beneficial effects of metformin on improving pain, activity of daily living, Sport/Rec, and quality of life in knee osteoarthritis patients.
Start Your Day With Whole Grains-Fiber can help lower cholesterol, prevent constipation, and improve digestion. And many Americans don’t eat enough of it. Look for whole-grain cereal or oatmeal with 3 or more grams of fiber per serving. Add fruit, and you’ll be on your way to the daily goal of 28 grams.
The video recording of the Linus Pauling webinar is now up on YouTube and can be found at: https://lpi.pub/Vitamin2023. Also, our document 100 Questions About Vitamin C, mentioned int webinar, can be found here: https://lpi.pub/VitC100Q
