SUBJ: rejuvenation of the body may become commonplace within our lifetimes
SUBtitle: Roc’s Conference abstract on reducing cancer and dementia risk
I skipped a few days, so there is a lot to read today. Feel free to skim long notes. You are wonderful to care for your health!
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SHORT NOTES: “rejuvenation of the body may become commonplace within our lifetimes”; Roc’s Conference abstract on reducing cancer and dementia risks; How Much Vitamin C Do You Need? Symposium on Tuesday, February 28; a 15 min. podcast on tai chi health benefits; optimum dosage of niacin is 600 mg; arthroscopic surgery leads to little or no difference in pain or function at three months after surgery; lithium supplementation is beneficial for health; Bifidobacterium longum supplementation improves age‐related delays in fracture repair; laughter makes us healthier; 7.3%…of all respondents reported long COVID, corresponding to approximately 18,828,696 adults; 57% of Americans believe healthcare should be ensured by the federal government; The highest rate of burnout among US doctors is primary care providers at 79%!; Expert uses 20 mg of Rapamycin for longevity, but getting 10-20mg of Rapamycin may do more harm than good; For Japanese supercentenarians, exceptionally healthy longevity depends not only on maintaining young epigenetic states but also on advanced states of specific epigenetic regions; It’s not always possible to prevent dementia. However, eating a nutritious diet, being physically active, avoiding smoking, and improving brain health may reduce risk; non-obese adults who were randomly chosen to eat 25% fewer calories aged a little slower than those who ate as much as they want; 15 Ways to Feel Happier- Scientists say walking tall with swinging arms helps you feel more positive. When you smile like you mean it, you can change your brain’s chemistry and feel …;resveratrol combined with plant extracts shows the best synergistic effects to slow aging; The Worst Foods for Your Brain-Margarine and Frosting, Soda, diet sodas, and Other Sugary Drinks; 7 best exercises: walking, squats …lunges; Signs of heart disease-leg or hip pain while walking, erectile dysfunction…;You’re constipated if you have less than three bowel movements a week for about 3 weeks; what to expect in your 70s – Parts of your brain shrink as you get older, You may need to cut calories to prevent weight gain…
LONG NOTES:
Commenting on the work in 2020, in which old mice were changed into young mice by changing epigenetic (DNA methylation) labelling of DNA, Prof David Sinclair, a leading expert on ageing at Harvard medical school, said if the finding held up, “rejuvenation of the body may become commonplace within our lifetimes”. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
Roc’s Conference abstract
Optimizing Immune Health: How Much Vitamin C Do You Need? on Tuesday, February 28 at 2 pm pacific time. This webinar is free to everyone, but registration is required.
Here’s a quick 15 minute podcast on tai chi and some of its health benefits-heart and immune system, weight loss and more.
β nicotinamide mononucleotide (a form of niacin) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety. This randomized,multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial included 80 middle-aged healthy adults being randomized for a 60-day clinical trial with once daily oral dosing of placebo, 300 mg, 600 mg, or 900 mg NMN.”Clinical efficacy expressed by blood NAD concentration and physical performance reaches highest at a dose of 600 mg daily oral intake of β nicotinamide mononucleotide.”
A 2022 study from Melbourne, Australia, reports, “High-certainty evidence indicates arthroscopic surgery leads to little or no difference in pain or function at three months after surgery, moderate-certainty evidence indicates it is probably little or no improvement in knee-specific quality of life three months after surgery. Stem Cell Therapy In Newport Beach, CA Area: Regenerate Knee Cartilage With Bone Marrow Concentrate And PRP.
More evidence that lithium supplementation is beneficial for health: https://www.aging-us.com/article/204476/text
Bifidobacterium longum supplementation improves age‐related delays in fracture repair. Dietary supplementation with the probiotic species Bifidobacterium longum (B. longum) accelerated and enhanced femoral fracture repair in aged mice as well as attenuated many of the systemic consequences of fracture. Bifidobacterium longum supplementation prevented gut leakiness, dampened inflammation, and maintained the community structure of the gut microbiota throughout bone repair. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13786
In an article published in the Harvard Gazette, Natalie Dattilo – the former director of psychology at Brigham and Women’s Hospital makes the case that laughter makes us healthier. She argues that laughter gives us that feel good sensation, helps us to come closer to those around us and can even help manage conditions like depression. In the article, she notes that: “Health care is expensive. If we can find a tool that is as simple as laughter, that is free for the most part, with no side effects and has no contraindications, that would be really great
From Kevin Fickensher” After much debate, the immunologists who study COVID are moving toward a policy which recognizes that a booster will have only marginal benefit if given just two months after a previous shot or, three to four months after an infection. One of the lead vaccine researchers at Harvard and a lead developer for the Johnson & Johnson vaccine has, in fact, boldly stated that: “The longer you wait, the better the boost.” Are COVID Boosters Effective Against All The Variants? – The short answer is “YES!” According to the CDC, the finds show that the bivalent vaccine are: 52% effective against BA.5, 48% effective against XBB/XBB.1.5 among those aged 18-49 although only 37% effective among those aged 65 years and older. The results are from a “survey of a random sample of 3,042 U.S. adults…[that]…“estimated 7.3%…of all respondents reported long COVID, corresponding to approximately 18,828,696 adults.” the effects of Long COVID (e.g. chest pain, cough, muscle aches, hair loss) tended to resolve or fade away after one year following a mild infection.
A new Gallup Poll shows that 57% of Americans believe healthcare should be ensured by the federal government.
More than half of USA doctors indicated that they know a colleague who has left clinical care due to burnout and 1/3 of all clinicians note that they are considering a departure from clinical care. The highest rate of burnout is among primary care providers at 79%!
If there seems to be a specialist in mTOR and Rapamycin, it’s Blagoskonny, he uses 20 mg of Rapa in this video, now it remains to be seen whether he, the great specialist, is right or wrong?
https://twitter.com/Blagosklonny/status/1445934725512765445
I notice that Bryan Johnson’s blueprint indicates that he also takes his rapamycin bi-weekly (13 mg). Getting 10-20mg of Rapamycin may do more harm than good, as there is a complete inhibition of mTORC1 and it can also affect mTORC2 which I believe is not good for cell health. 5mg does a partial inhibition which is what I recall is the ideal state. I notice that Bryan Johnson’s blueprint indicates that he also takes his rapamycin bi-weekly (13 mg)
Epigenetic profile of Japanese supercentenarians: a cross-sectional study
Interpretation These results indicate that exceptionally healthy longevity depends not only on maintaining young epigenetic states but also on advanced states of specific epigenetic regions. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00002-8/fulltext
It’s not always possible to prevent dementia. However, eating a nutritious diet, being physically active, avoiding smoking, and improving brain health may reduce risk.
A new paper says non-obese adults who were randomly chosen to eat 25% fewer calories aged a little slower than those who ate as much as they want.
WebMD 15 Ways to Feel Happier- Scientists say walking tall with swinging arms helps you feel more positive. When you smile like you mean it, you can change your brain’s chemistry and feel happier. Find ways to get involved in your community or help out a friend in need. It makes you feel good to spend time with people who care about you. Write down everything that’s good in your life. It can take as little as 5 minutes for exercise to put you in a better mood. Are you holding a grudge? Let it go. Forgiveness frees you from negative thoughts and makes more room in your life for inner peace. Meditate for an hour a week. Music can have a powerful effect on your emotions. Most adults need 7 or 8 hours of sleep each night to stay in a good mood. When you have a sense of purpose — why you work, exercise, or do something good for someone else — it gives your life meaning. You know that inner voice that loves to point out everything that isn’t so great? Try to notice when it takes control of your mood. Sometimes it has a good point and is letting you know about something that needs your attention. But other times, it’s wrong, or it makes things seem worse than they are. Ask yourself, “Is this true?” Ask yourself if your goals are realistic and within your reach now — or at least, things that you can start to work toward. Then get really specific about what the goal is. “Emotions are contagious,” as the saying goes. So you want people in your life who are confident, upbeat, and healthy. If you feel a lot less happy than you used to, even after you try the tips in this slideshow, it’s time to call an expert. Book a session with a counselor to talk about how you feel.
Compound combinations targeting longevity: Challenges and perspectives☆
Highlights • Using combinations of compounds for anti-aging therapy is a promising strategy. • The effects of combinations with metformin, rapamycin, rifampicin are best studied. Synergistic combinations multiply life extension and alleviate adverse effects. Combinations of compounds causing synergistic anti-aging effects are of most interest. • For now, resveratrol combined with plant extracts shows the best synergistic effects.
The Worst Foods for Your Brain-You’ve been loading up on colorful berries, nibbling on nuts, and dining on salmon — all good moves if your goal is better brain health. But what about foods that might raise your risk for mood or memory problems, especially as you get older? Margarine and Frosting, too much alcohol, Soda, diet sodas, and Other Sugary Drinks, French Fries and Other Fried Foods, Doughnuts, White Bread and White Rice, Red Meat, Butter and Full-Fat Cheese, Swordfish, ahi tuna, and other big fish lose points because they tend to be high in mercury. Bottled Dressings, Marinades, and Syrups.
WebMD 7 best exercises: walking, vary the intensity within your workout, squats, Practice with a real chair to master this move, lunges, Try stepping not just forward, but also back and out to each side, with each lunge, push ups, crunches, Keep your neck in line with your spine. Tuck in your chin so it doesn’t stick out. Breathe normally. To keep chest and shoulders open, keep your elbows out of your line of vision, bent over row with weights.
AARP Signs of heart disease: you struggle to breathe lying flat, leg or hip pain while walking, erectile dysfunction, vaginal dryness, swollen ankles, normal activities make you tired, bad breath, Known as xanthomas, these fatty growths feel like calcium deposits in the tendons, and they can indicate sky-high cholesterol, feeling nauseous,
You’re constipated if you have less than three bowel movements a week for about 3 weeks.
WebMD – what to expect in your 70s – Parts of your brain shrink as you get older, and signaling between different areas can slow. That means you may have trouble remembering names or coming up with a specific word. It may be harder for you to multitask and pay attention. As you age, your heart can’t beat as fast during exercise or when you’re stressed. As its walls get thicker and its valves get stiffer, blood may not flow through as efficiently. Age spots and wrinkles are no surprise, but you may also find that you bruise more and sweat less. You may need to cut calories to prevent weight gain. About 1 in 4 women — and some men, too — over 65 have osteoporosis, a bone-thinning disease. Your muscles get weaker, and the tendons — which connect muscles to your skeleton — get stiffer. This will decrease your strength and flexibility. In your 70s, you might lose an inch or two off your height as disks in your back flatten. Exercise, especially the weight-bearing kind, can help prevent these changes and may even reverse them. you spend less time each night in deep sleep and more in lighter phases. Your body’s defenses lose a step in your 70s, which leaves you more vulnerable to illness. Vaccines don’t work as well as they once did for you (but taking vitamin E several days before vaccinations makes them much more effective – so use AREDS2 every day). Your stomach lining is more fragile, which raises your odds of having ulcers (but that is caused by an infection that can be prevented by taking peptobismol.) Your bladder can’t hold as much as it once did, and your muscles that support it have lost some strength. Research suggests that more people in their 70s today are sexually active than in previous eras. Your pupils react more slowly to changes in light, because your eye muscles are a bit weaker. About one-third of people ages 65-74 have hearing loss, and about half of those over 75 do.
