SUBJ: Allowing subscriptions
SUBtitle: Cold weather can actually contribute to getting a cold
Happy New Year! We have survived another tripledemic. I SURE Appreciate the many kind responses I have received for my holiday gratitude. Thanks so much. -Roc
SHORT NOTES: Thanks to the many donors who have pledged to support this newsletter and website; Cold weather can actually contribute to getting a cold; If your emotions are inflamed, so is your biology; Therapies that slow hypomethylation might alleviate inflammation or other aging-associated deficits. [SAMe]; Exposure to stress shortens telomeres, even in unborn children; 20% of patients 65+ take dangerous combinations of medicines, causing 12 million hospitalizations in the US; a ‘perfect diet’ would have to be low in methionine and glycine, and high in phenylalanine, tryptophan, and valine; Your bone mass reaches its peak between your mid 20s and mid 30s, “Too much calcium could be harmful; 6 movement mistakes- Bending from the waist or rounding your lower back to pick up something from the floor..; best exercise for mature people is a set of squats; Higher inflammation scores were associated with smoking and older age, higher BMI, systolic blood pressure, lipids, and glucose levels, and with greater odds of hypertension and diabetes after adjusting for age, sex, cohort, and BMI; Zinc is essential for the growth and differentiation of immune cells; Dry eye is a disease that severely affects patients’ quality of life; 3D-printed synthetic corneas and retinas; to remove skin tags, you could snip off the skin tag at the bottom using a pair of scissors that have been sterilized.
LONG NOTES:
Allowing subscriptions. Thanks to the many donors who have pledged to support this newsletter and website. Some have asked to subsribe, and the newsletter distributor I use has asked me to allow people to subscribe if they wish. It is set up so that 1% of your subscription money goes to support rainforests. You are welcome to continue to get it for free.
Cold weather can actually contribute to getting a cold. Cold exposure impairs extracellular vesicle swarm–mediated nasal antiviral immunity.Our study provides a direct quantitative mechanistic explanation for seasonal variation in upper respiratory tract infection prevalence.
From Mark Hyman, MD: The truth is you cannot live a healthy, happy, fulfilled, and long life while neglecting to nourish your mind and spirit. If your emotions are inflamed, so is your biology. As author and medical intuitive Caroline Myss says, “Your biography becomes your biology.” Practicing self-compassion can significantly help people improve their health behaviors, like quitting smoking, exercising, eating healthier or overcoming eating disorders, practicing self-care, and improving overall well-being.
Sci 23 Dec pg 1277: Epigenetic clocks, aging and cancer [https://www.science.org/doi/10.1126/science.abn4009] – mitotic hypomethylation clock restrains aging cells from becoming cancerous-as cells divide, CpG regions that are methylated when young lose their methylation in subsequent cell divisions and become senescent. Therapies that slow hypomethylation might alleviate inflammation or other aging-associated deficits. [Might SAMe, which declines with age but is responsible for methylation, alleviate hypothmethylation?]
Sci 23 Dec pg 1293: The legacy of stress: Exposure to stress shortens telomeres, even in unborn children. This was especially the case for white but not Black mothers in financial stress during pregnancy.
An exciting year with new clinical trials to cure cancer and treat cystic fibrosis. 20% of patients 65+ take dangerous combinations of medicines, causing 12 million hospitalizations in the US. Have you checked with your doctor recently?
Diet is an important component of a healthy lifestyle and is believed to play a major role in health status and longevity. various countries have developed official dietary guidelines. amino acids are categorized into subgroups: essential, nonessential, ketogenic, branched-chain, and glucogenic. the researchers made a total of 2,335 amino acid profiles of various foods such as eggs and pork. They show that glutamate/glutamine and asparagine/aspartate are the most abundant in human foods. On the other hand, cystine and tryptophan are the least abundant. Some amino acids, such as methionine, vary greatly in different foods: they comprise 3.1% of the amino acids in eggs but only 1.3% in legumes. plant-based diets are characterized by a lower abundance of lysine, histidine, and methionine. the researchers found that the amino acid intake correlated with age, but not other demographic features. obese people were more likely to consume foods rich in methionine and poor in tryptophan. Surprisingly, the association between consumed amino acids and diseases was stronger than between diseases and carbs or fats. a ‘perfect diet’ would have to be low in methionine and glycine, and high in phenylalanine, tryptophan, and valine. Unexpectedly, none of the existing diets considered in this study satisfied these conditions.
WebMD- to strengthen bones, Your bone mass reaches its peak between your mid 20s and mid 30s, If your calcium levels are too low, your body takes it from your bones (but NIH states most Americans get plenty in their diet. Calcium supplements harden tissues and increase risk of heart disease. Check with your doctor and see if they are aware of risk from calcium supplements), the man who sets the RDA for vitamin D recommends at least 2,000 IU daily as a supplement, WebMD says “Too much could be harmful.” But experts now say 10,000 IU daily is safe, and many experts and I take 5,000 IU daily, as it reduces risk for COVID and colds, Adults who work out can help prevent bone loss that usually starts in your 30s. Bonus: Exercise builds muscles, which help improve your balance and coordination. Weight-bearing activities are best-running, walking, dancing, climbing stairs, etc. -30 min a day! Quit smoking and eat less sugar, WebMD fails to state that the phosphate in coke and most soft drinks eats your bones, sucking out calcium very effectively. People in India eat little calcium, exercise a lot, and do not drink much soda – and have almost no osteoporosis.
AARP – 6 movement mistakes- Bending from the waist or rounding your lower back to pick up something from the floor. Initiating a squat movement from the knees, rather than the hips. Letting your knees collapse inward when you bend them. Walking flat-footed rather than rolling through your feet. Locking your knees when you’re standing still. Looking at the ground while you walk.
AARP – best exercise for mature people is a set of squats. Keeping your back straight, chest up and heels planted, push your hips back like you are sitting in a chair. Try to keep your weight evenly distributed on both feet as you do the exercise, with your weight mostly on your heels, not your toes.
Assessing an individual’s systemic inflammatory state is vital to understand inflammation’s role in cardiometabolic diseases and identify those at the greatest risk of disease. Higher inflammation scores were associated with smoking and older age, higher BMI, systolic blood pressure, lipids, and glucose levels, and with greater odds of hypertension and diabetes after adjusting for age, sex, cohort, and BMI. Systemic Inflammation is Associated with Cardiometabolic Risk Factors and Clinical Outcomes.
Zinc is essential for the growth and differentiation of immune cells. Zinc insufficiency affects immune system function, thereby increasing infection susceptibility, autoimmunity, and allergies. Zinc Modulates the Priming of T Helper 1, T Helper 17, and T Regulatory Cells in Allogeneic and Autologous in vitro Models.
Dry eye is a disease that severely affects patients’ quality of life, increasing the global burden on public health and finance. There is growing evidence that a poor lifestyle is a significant risk factor for dry eye. Along with the development of society, sleep, as a way of life, is also constantly changing. The main manifestations of sleep disorders are reduced sleep time, circadian rhythm disturbances, and sleep breathing disturbances. Sleep disorders and their secondary systemic diseases have attracted wide attention in recent years.The Association Between Dry Eye and Sleep Disorders: The Evidence and Possible Mechanisms.
Israel’s Precise Bio is developing 3D-printed synthetic corneas and retinas to enable visually impaired people to see clearly again. Precise Bio takes donated cells, grows them in the lab, and then 3D-prints them onto a biological scaffold. Looking forward to news of future clinical trials.
AARP to remove skin tags, you could snip off the skin tag at the bottom using a pair of scissors that have been sterilized by boiling them or wiping them off with rubbing alcohol. “do it at your own risk”
