SUBJ: dietary supplements may have anti- cardiovascular disease and cancer effects

SUBtitle: People are happiest when fed nutrient-dense foods

Wishing you sleep and nutrient dense foods for the challenges of December.

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SHORT NOTES: Inflammation and oxidative stress have been shown to have a role in both cardiovascular disease and cancer, and dietary supplements may have anti-inflammatory and antioxidative effects; People are happiest when fed nutrient-dense foods;  certain diets trigger inflammation;  Sleep disorders significantly increase the risk of cognitive impairment;  Sleep Restriction Reduces Cognitive but Not Physical Motivation;  nutmeg (Myristica fragrans) strongly inhibited harmful catalytic activity of 5-lipoxygenase; The healthful role of vitamin D on redox regulation and cellular senescence;  More than 1 in 4 adults in the U.S. have untreated tooth decay, and half of everyone over 30 have signs of gum disease. brush a minimum of 2 minutes each time by repetition, not force

LONG NOTES:

June 21, 2022, Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer US Preventive Services Task Force Recommendation Statement. Inflammation and oxidative stress have been shown to have a role in both cardiovascular disease and cancer, and dietary supplements may have anti-inflammatory and antioxidative effects.

AARP brain food –  happiest when fed nutrient-dense foods;  certain diets trigger inflammation; Eating to support your brain is choosing minimally processed or unprocessed foods,” fish,  The Global Council on Brain Health found that a plant-based diet rich in green leafy vegetables and berries contributes to better brain health, while a diet high in red meat, saturated fats, sugar and salt can harm your brain health.

Sleep disorders significantly increase the risk of cognitive impairment.  Very bad sleep quality and greater sleep fragmentation before stroke were identified as independent risk factors for post-stroke cognitive impairment at 3 months after stroke.

Sleep Restriction Reduces Cognitive but Not Physical Motivation. Motivation is an important driver of behaviour, and several frameworks distinguish the willingness of individuals to invest cognitive versus physical effort to achieve a goal. The results suggest that sleep restriction has a selective effect on cognitive over physical motivation, which has significant implications for real-world settings in which individuals must maintain high levels of cognitive motivation in the face of chronic sleep loss.

 

As pro-inflammatory lipid mediators, leukotrienes have pathophysiological activities in several inflammatory diseases, including psoriasis. In the biosynthesis of leukotrienes from arachidonic acid, 5-lipoxygenase catalyzes the first two steps. In the present study, we showed that nutmeg (Myristica fragrans) strongly inhibited the catalytic activity of 5-lipoxygenase. activity and ameliorates psoriasis-like skin inflammation in mice

The role of vitamin D on redox regulation and cellular senescence
Highlights
• Vitamin D non-canonical effects influence age-related diseases.
• Its analogs and metabolites can enhance therapeutic action and avoid side effects.
• Redox regulation by vitamin D is mediated by its antioxidant and mitohormetic action.
• Vitamin D properties modulating cellular senescence seem useful in senotherapeutics.
• Single-cell sequencing can contribute to elucidating cell type-dependent effects.

WebMD-toothbrushing, More than 1 in 4 adults in the U.S. have untreated tooth decay, and half of everyone over 30 have signs of gum disease. brush a minimum of 2 minutes each time by repetition, not force, twice a day, only need a pea-sized amount of toothpaste, Wait at least 30 minutes after you eat to brush,  or if you’re in a hurry, rinse with water or use mouthwash to neutralize the acid, tilt brush up a bit so it’s at a 45-degree angle to your gums. Then move the brush head from tooth to tooth, using a small circular motion, floss, clean tongue gently from back to front a few times, lifespan of a toothbrush is about 3 to 4 months.