SUBJ: 10mg spermidine daily for cognitive and immune function
SUBtitle: coffee and olive oil to reduce age-associated disease
So much news this week! Summary of evidence below-take spermidine (3mg/day), drink 5 cups of coffee daily, feed microbiome (kefir/yogurt, fiber), eat lots of olive oil, increase grip strength, take vitamin D, avoid and get off antidepressants (use SAMe), use melatonin for sleep
SHORT NOTES: I am now taking 10mg spermidine daily as a supplement for cognitive and immune function; Coffee intake of up to 5 cups per day was associated with significant reductions in the risks of age-related disease; Poor microbiome causes arthritis; a strong association between olive oil consumption and lower risks of age-related disease; Handgrip strength might be a positive indicator for cognitive function; Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive function; Melatonin’s Benefits as a Therapy for Sleep and inflammaging; there is no reason to stop taking your vitamin D supplements; dietary supplements can interfere with the action of drugs, the LPI Institute’s Drug-Nutrient Interactions app can protect you; vitamin C as a sepsis therapy for at least five days; Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic inflammation; Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing; Survivingantidepressants.org, “They are poorly prescribed, and HAZAROUS.” 10-15% of Americans take SSRIs. Drugs are to be reserved only for more severe depression”; Engeletin Alleviates the Inflammation and Apoptosis in low back pain; research has revealed a possible link between sleep disorders and erectile dysfunction; ways to be younger-spend time with friends, exercise, brush and floss…; Best foods to keep in your fridge-turkey, salsa, yogurt, avocado, berries…
LONG NOTES:
Sci 28 Oct, pg 370-Spermidine decreases with age, supplementation in mature people activates aged T-cells and improves anti-tumor immunity. (I am now taking 10mg spermidine daily as a supplement).
The results demonstrated a clear correlation between the intake of spermidine and the improvement in cognitive performance in subjects with mild and moderate dementia in the group treated with the higher spermidine dosage.
Coffee intake of up to 5 cups per day was associated with significant reductions in the risks of cardiovascular disease, congestive cardiac failure, coronary heart disease, ischemic stroke, and various arrhythmias.
Sci 28 Oct, pg 367-Poor microbiome causes arthritis (I drink kefir and eat fiber every morning to maintain a healthy microbiome);
In the journal Nutritional Epidemiology, scientists have found a strong association between olive oil consumption and lower risk of cardiovascular, cancer, and all-cause mortality [1].
Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies. Handgrip strength (HGS), a measure of muscular strength, might be a risk indicator for cognitive functioning, but the evidence is not consistent. Using a new prospective study and meta-analysis of published observational cohort studies, we aimed to evaluate the prospective associations of HGS with poor cognitive outcomes including cognitive impairment, dementia and Alzheimer’s disease (AD). Meta-analysis of aggregate prospective data suggests that HGS may be a risk indicator for poor cognitive outcomes such as cognitive impairment, dementia and AD. Systematic review registration.
Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia. Insomnia, a chronic condition affecting 50% of older adults, is often accompanied by cognitive decline. We tested associations between sleep quality and cognitive performance with gut microbiota in older adults with insomnia. Findings demonstrate the associations of sleep quality and cognitive performance with variance in gut microbiota composition and with specific genus abundance in older adults with insomnia.
Melatonin’s Benefits and Risks as a Therapy for Sleep Disturbances in the Elderly: Current Insights. Aging is accompanied by circadian changes, including disruptive alterations in the sleep/wake cycle, as well as the beginning of low-degree inflammation (“inflammaging”), a scenario that leads to several chronic illnesses, including cancer, and metabolic, cardiovascular, and neurological dysfunctions. Every day, the late afternoon/nocturnal surge in pineal melatonin helps to synchronize both the central circadian pacemaker found in the hypothalamic suprachiasmatic nuclei (SCN) and a plethora of peripheral cellular circadian clocks. Melatonin is an example of an endogenous chronobiotic substance that can influence the timing and amplitude of circadian rhythms. Moreover, melatonin is also an excellent anti-inflammatory agent, buffering free radicals, down-regulating proinflammatory cytokines, and reducing insulin resistance, among other things. We present both scientific and clinical evidence that melatonin is a safe drug for treating sleep disturbances in the elderly.
LPI Newsletter- two studies on vitamin D caused a bit of a stir, inciting some media reports that proclaimed vitamin D supplements are “useless” for supporting bone and immune health. Here, we discuss the important findings from these vitamin D trials and provide some context and perspective. In short, there is no reason to stop taking your vitamin D supplements
LPI Newsletter- Some dietary supplements can interfere with the action of drugs, and some drugs can influence how certain nutrients act in the body. It is incredibly important for physicians and consumers alike to be aware of potential interactions. This is where the Institute’s Drug-Nutrient Interactions (DNI) app plays an important role in healthcare. Developed from information in the Micronutrient Information Center and funded by a grant from Pfizer, Inc., this app is freely available for both Android and iOS devices. The DNI app was developed to be a quick and easy reference for physicians, yet is simple enough for anyone to use. The app focuses on clinically relevant drug-nutrient interactions.
LPI Newsletter- Is there a path forward for IV vitamin C as a sepsis therapy? Earlier this year, a study from Korea suggested that IV vitamin C should be administered for at least five days to provide a significant benefit to sepsis patients. Since many randomized clinical trials only provided IV vitamin C for up to four days, extending the treatment period is one avenue to explore in future studies.
Senescent macrophages in the human adipose tissue as a source of inflammaging. Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic inflammation. Recent evidence suggests that an increased burden of senescent cells (SCs) in the adipose tissue of obese/diabetic animal models might underlie such pro-inflammatory phenotype. In morbid obesity, expansion of visceral adipose depots involves an increased burden of macrophages with senescent-like phenotype that may promote a pro-inflammatory profile and impair insulin signaling in adipocytes, supporting a framework where senescent macrophages fuel obesity-induced systemic inflammation and possibly contribute to the development of insulin resistance.
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies. Mitochondrial reactive oxygen species (mtROS) are cellular messengers essential for cellular homeostasis. In response to stress, reverse electron transport (RET) through respiratory complex I generates high levels of mtROS. Suppression of ROS production via RET (ROS-RET) reduces survival under stress, while activation of ROS-RET extends lifespan in basal conditions. Our results elucidate the mechanism by which ROS signalling is lost during ageing.
Survivingantidepressants.org, Economist 10/22 pg 66 – Everyone on antidepressants really should read this article!! “They are poorly prescribed, and HAZAROUS.” 10-15% of Americans take SSRIs. To reduce dependence, one should only reduce level by 10% weekly each 2 to 4 weeks. “For less severe levels of depression, self-help guidance, behavioral therapy and recommendation for things like exercise and sleep are preferable…Drugs are to be reserved only for more severe depression.”
Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways. Low back pain (LBP) induced by intervertebral disc degeneration (IDD) brings progressively painful status and impairs the normal daily living. Engeletin is a plant-derived medicine with anti-inflammation and antioxidant functions. As a natural compound with little cytotoxicity, engeletin possesses the outstanding anti-inflammation and anti-apoptosis effects in the process of IDD in vitro and in vivo, which may be a promising medicine for the prevention and treatment of IDD-related low back pain.
Short Sleep Duration and Erectile Dysfunction: In modern society, short sleep duration is becoming a global problem. It has been established that short sleep duration can increase the risk of several diseases, such as cardiovascular and metabolic diseases. A growing body of research has revealed a possible link between sleep disorders and erectile dysfunction
WebMD-ways to be younger-spend time with friends, do something creative, exercise, learn something new, brush and floss, quit smoking
Best foods to keep in your fridge-turkey, salsa, humus, eggs, kale, seltzer, yogurt, celery, tortillas, cabbage, avocado, berries
