SUBtitle: ..Dirty air in cities causes Alzheimers

Aristotle “It is best to rise from life as from a banquet, neither thirsty nor drunken”

Links for new readers: 1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span

I am thankful to all who read my newsletter, and grateful to those who sponsor it. In 2026, donations will be tax deductible: EIN 41-4344774.  Link to subscribe to newsletter

To be removed from the nutrition list distribution, please email ordman@beloit.edu SUBJ: remove from list. All writings are to discuss with your physician. Full Disclaimer

SHORT NOTES:

1.. National recommendation is 10,000 steps a day, and I averaged 9,200.

2..Dirty air in cities causes Alzheimers, as well as stroke, depression, and hypertension.

3..g high cholesterol-150 min. brisk exercise a week, a heart-healthy diet that’s low in saturated and trans fats.

4..Fatty 15 is a supplement with many anti-aging claims.

5..U.S. centenarian population will quadruple over the next 30 years, currently 0.3 %.

6..Let’s Get Back to Health: 4 Easy Steps For Maintaining Health in 10+ minutes a day.

7..The USA recorded 2,012 measles cases, the highest total in more than 30 years .

8.. “…at least 4.6 million flu-related illnesses…49,000 hospitalizations and 1,900 deaths because of insufficient efforts to distribute and immunize the American public!

9..Poor heart health was nearly 80% more prevalent among night owls.

10..Gut Microbiota prevenbt Neurodegenerative Diseases.

11..α – lipoic acid reduces oxidative stress, inflammatory responses, and brain atrophy.

12..Plants need dusting.

LONG NOTES:

From a clinical trial I am in:  Adults aged 65 and older need:

• At least 150 minutes a week (for example, 30 minutes a day, 5 days a week) of moderate intensity activity such as brisk walking. Or they need 75 minutes a week of vigorous-intensity activity such as hiking, jogging, or running.
• At least 2 days a week of activities that strengthen muscles.
• Activities to improve balance such as standing on one foot about 3 days a week.

National recommendation is 10,000 steps a day, and I averaged 9,200.

How do you know if you’re doing moderate or vigorous aerobic activity?

On a 10-point scale, where sitting is 0 and working as hard as you can is 10, moderate-intensity aerobic activity is a 5 or 6. It will make you breathe harder and your heart beat faster. A rule of thumb is that 1 minute of vigorous-intensity activity is about the same as 2 minutes of moderate-intensity activity. To gain health benefits, you need to do muscle-strengthening activities to the point where it’s hard for you to do another repetition without help. A repetition is one complete movement of an activity, like lifting a weight or doing one sit-up. Try to do 8-12 repetitions per activity, which counts as 1 set. Try to do at least 1 set of muscle-strengthening activities, but to gain even more benefits, do 2 or 3 sets.

NPR Science Friday did a program on how foul the air is in big cities.  Dirty air causes Alzheimers, as well as stroke, depression, and hypertension. Long term exposure to fine particulate air pollution, common in large cities and especially near power plants, increases risks for these health problems.

AARP- Warning Signs of High Cholesterol Your annual checkup includes routine blood tests that measure cholesterol. Here’s what you need to know about high cholesterol — the causes, risk factors, treatments and best ways to prevent it. Preventing high cholesterol-150 brisk exercise a week, and eating a heart-healthy diet that’s low in saturated and trans fats.

Fatty 15 is a supplement with many anti-aging claims: Strengthens cell membranes by 80%, Improves mitochondrial function by up to 350%, helps lower bad LDL cholesterol and improves liver enzymes.  The doctors at the Navy went on to develop a pure C15:0 supplement called fatty15, whose benefits to our health are now supported by more than 100 peer-reviewed studies.

U.S. centenarian population is projected to quadruple over the next 30 years, from an estimated 101,000 in 2024 to about 422,000 in 2054, according to projections from the U.S. Census Bureau. Centenarians currently make up just 0.03% of the overall U.S. population, and they are expected to reach 0.1% in 2054.

Let’s Get Back to Health: Easy Steps For Maintaining Health – Aging well is an important element of getting older. The New York Times recently had a piece on the topic outlining four areas of assessment that are predictive of getting older in a healthy way, including outlines of the:

1. Sitting-Rising Test (= 5 points for standing from sitting position and 5 points for sitting from standing with one point lost for each time you use a hand, arm, or any other objective to help you do either standing or sitting),
2. Walking Speed Assessment (= walking 13 feet in about 3 seconds),
3. Grip Strength Test (= walking for 60 seconds while carrying a heavy object, aka the farmer’s carry); and,
4. Single Leg Stand (= standing on one leg for a minimum of 10 seconds)!! Yikes!!!

You can check out the details here. And, you can practice these four simple tests every day to gain the strength and capability to meet the standards outlined above. All it takes is about 10+ minutes every morning when you get up and at ‘em!!

The USA recorded 2,012 measles cases, the highest total in more than 30 years – and, the incidence is expected to grow as immunizations continue to fall. One of the complications of a measles infection is the onset of Acute Encephalitis (brain swelling), which can turn into Subacute Sclerosing Panencephalitis (SSPE). It’s a complication that leads to permanent brain damage.

The current CDC estimate is: “…at least 4.6 million flu-related illnesses…49,000 hospitalizations and 1,900 deaths this season, which (will run) through March or April…” – all because of insufficient efforts to distribute and immunize the American public!!

Science 19 Feb 2026 pg 779-Unhealthy night owls? Kianersi et al. examined over 300,000 middle-aged and older participants of the UK Biobank who completed surveys about chronotypes; that is, the time of day when they feel more alert and active (e.g., “morning person” versus “night person” or intermediate). Each participant received a heart health score based on their sleep quality, cholesterol, blood sugar, blood pressure, exercise, nutrition, weight, and smoking status. Compared with intermediate participants, poor heart health was nearly 80% more prevalent among night owl participants. Night owls also had a higher risk of heart attacks and strokes after 14 years, suggesting that this group may need tailored interventions to mitigate cardiovascular risks. Pg 779 – Lungs have guts – Gut bacteria modulate the immune system through the release of microbial-derived compounds, including shortchain fatty acids (SCFAs). Maruyama et al. investigated the influence of the gut microbiome on the response to lung injury in mice. In a mouse model of sterile lung injury, a fiber-rich (FR) diet reduced inflammation compared with a fiber-free (FF) diet. Conversely, in a model of infectious lung injury, a FR diet exacerbated inflammation. The FR diet increased the production of SCFAs that in turn modulated the transcriptional signature of alveolar macrophages. These results suggest that injury-specific dietary intervention might accelerate recovery after lung injury.

The Effect of the Mediterranean Diet on Gut Microbiota and Its Impact on Neurodegenerative Diseases: A Narrative Review. The Mediterranean Diet (MD) is anti-inflammatory, antioxidant, and gut-modulating due to its high vegetable, fruit, whole grain, and olive oil intake. It boosts beneficial GM and their byproducts, which suppresses inflammation and may slowing progression and improve PD, AD, MS, and NMOSD, influencing disease progression and symptoms. This review aims to investigate the interaction between GM composition and the MD and how they jointly influence neurodegenerative diseases such as AD, PD, MS, and NMOSD.

Linking Mechanisms of Lipoic Acid to Multiple Sclerosis: A Narrative Review
The effect of lipoic acid supplements on patients with multiple sclerosis (MS) has been widely studied, yet the evidence remains inconclusive, and more research is needed to draw definitive conclusions. This review aimed to comprehensively assess the impact of α – lipoic acid (ALA) on oxidative stress, inflammatory responses, and brain atrophy.

Roc, is is often hard to change the conditions of our life. So I have plants but they need dusting too! And I find it hard to do that. What would you suggest? Patience. Your plants appreciate it.

SUBtitle: May your health and spirit be joyful in the coming year

Neglect kills injuries, Revenge increases them.  Poor Richard’s |Almanac

Links for new readers: 1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span

I am thankful to all who read my newsletter, and grateful to those who sponsor it. Link to subscribe to newsletter

To be removed from the nutrition list distribution, please email ordman@beloit.edu SUBJ: remove from list.

All writings are to discuss with your physician. Full Disclaimer

SHORT NOTES:

1.. “White Christmas has endured for decades because it offers us something we desperately need: a reminder of the transformative power of generosity and community.

2..Turmeric might be effective in the treatment of depression.

3.. Healthcare costs in the US are 20+% of GDP. In England, 12%.

4..The “health benefits” of switching to Green Tea as an alternative to coffee.

5.. Cancer-fighting cells made in body help patients.

6..To deal with frequent nightmares, 3 steps.

7..Check Out Kevin’s New Book (!!!!): The Persistence Factor

8.. AARP-6 medicines that may harm your kidneys- NSAIDs , Antibiotics, Laxatives…

LONG NOTES:

The Turmeric Solution For Effective Depression Tx?? – A recent notice that floated across my inbox from WebMD suggested that the use of the spice turmeric for spice turmeric might be effective in the treatment of depression.

AARP-6 medicines that may harm your kidneys-kidney disease is among the top 10 causes of death.  People who are most vulnerable to medication-induced adverse kidney events include those 65 and older, those with underlying kidney disease, people who are dehydrated, patients with low blood pressure, and those who have other health conditions such as diabetes, heart disease or have had heart surgery or transplantation. NSAIDs , Antibiotics, Laxatives, Contrast dyes, acid suppressants include omeprazole (Prilosec) and esomeprazole (Nexium), famotidine (Pepcid) and calcium carbonate (Tums), A 2007 review of supplement-induced kidney dysfunction lists more than 15 herbs and supplements reported to have caused kidney problems, including chromium, creatine, licorice, willow bark, and yohimbe.

Science 11 Dec pg 1084 – Cancer fighting cells made in body help patients. Approach could be faster than CAR-T cells. Immune cells engineered to home in on cancer cells like guided missiles can be lifesavers—if patients can get them in time. Currently, their T cells must be harvested and given a surface protein, a chimeric antigen receptor (CAR), through genetic manipulation, a slow and expensive lab process. Making the cells directly inside the body should be faster, and early clinical data now suggest the strategy can work. In one of the first trials, the approach induced the so-called in vivo CAR-T cells in four patients with multiple myeloma, a blood cancer, and evicted the malignant cells from their bone marrow.

Science 11 Dec pg 1107 – To deal with frequent nightmares, 3 steps.  Use the waking imagination to rewrite the dream with a happier outcome.  Dream engineering includes having pleasant music, light, and comfort items where you sleep.  Try to promote lucid dreaming – you set intentions and repeat phrases like “I will remember I’m dreaming” before sleep.

From Kevin Fickenscher: A recent notice that floated across my inbox from WebMD suggested that the use of the spice turmeric for spice turmeric might be effective in the treatment of depression. Turmeric is a common ingredient for many Indian and Asian foods and is found in the root stalk of curcumin. Wowser!!! Evidently, it works by settling the immune system a bit and the reason depression is impacted is that there is growing evidence that inflammation of the immune system is part of the problem.

Healthcare costs in the US are 20+% of GDP. In England, 12%, in France, 3.3%.  Cutting federal aid for health insurance will dramatically raise healthcare costs because many people will have to go to the emergency room instead of getting doctor care.

A recent report came out about the “health benefits” of switching to Green Tea as an alternative to coffee. First, green tea is widely consumed throughout the world as a $300 billion business and dates back to 3000 BC in China. It is derived from the Camellia Sinensis plant and holds anti-inflammatory and antioxidant properties, which are two elements that help to prolong life.

Check Out My New Book (!!!!): The Persistence Factor – www.amazon.com – focused on “how” to make change happen in the face of challenges requiring focused of energy and commitment toward solving problems over time…like the problems we face in today…

“White Christmas has endured for decades because it offers us something we desperately need: a reminder of the transformative power of generosity and community. [The] story teaches us that true fulfillment comes not from what we achieve for ourselves, but from what we do for others.”

This is a poster about the book I have written which I hope to publish after October 2025.   Search for Not FDA Allowed to find it.

How few there are that own their own faults, or resoluition enough to mend them!

Links for new readers:  1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span   3) Recent important nutrition news.  4) A financial contribution to this newsletter is less expensive and better for your health than a multivitamin. Please use this new Link to subscribe to newsletter for $52/year.  It will remind you annually to resubscribe. Sorry I am not set up as a non-profit. Donation link to a fund raiser for Nutrition Investigator travel to present research at professional meetings. To be removed from the nutrition list distribution, please email ordman@beloit.edu  SUBJ: remove from list. All writings are to discuss with your physician. Full Disclaimer

SHORT NOTES:

1..I am trying to raise $8,000 to publish my book Not FDA Allowed.

2..Fund raiser for Nutrition Investigator travel to present research at professional meetings.

3..The #1 Exercise for Belly Fat.

4..Fatty 15 improves mitochondrial function 45%, inhibit 18+ proinflammatory cytokines.

5..67,440 people in the U.S. will be diagnosed with pancreatic cancer in 2025.

6..Kidney grown in the lab.

7..Acupuncture in the Treatment of Vascular Cognitive Impairment.

8..The seminal paper in Cell had 12 hallmarks of aging.

9..Caloric restriction can shrink muscle mass, lower your libido, and suppress neuronal function.

10..Among the elderly, having difficulty bathing is as grimly determinative of mortality.

11..Only a quarter of the slowest walkers over 85 survived as long as the fastest walkers.

12..Genes determine only 7 to 30% of longevity.

13..Impact of diet and exercise on mitochondria in Alzheimer’s disease.

14..Mediterranean Diet Improves Mitochondria in Obesity and Metabolic Syndrome.

15..High-intensity Interval Training Improves  Mitochondrial Function.

16.. Endurance exercise rescues progeroid aging and  induces systemic mitochondrial rejuvenation in  mtDNA mutator mice.

LONG NOTES:

Dear Friends of me, Roc,

Please consider supporting my fundraiser by viewing the story here – http://spot.fund/19fgpbfce.  If my average friend gave $10, I would have enough.  For $100, you get the autographed book with my thanks.

I am trying to raise $8,000 to publish my book Not FDA Allowed.  I plan to refund all donations in about 5 months after the book is published and enough copies sell to pay for that $8,000 you helped contribute.  Thanks!

Donation link to a fund raiser for Nutrition Investigator travel to present research at professional meetings, especially the Linus Pauling meeting Sept 9^th.

AARP: The #1 Exercise for cBelly Fat. Lie flat on your back with knees bent, lift your feet and knees to horizontal.

Fatty 15 claims to improve mitochondrial function 45%, inhibit 18+ proinflammatory cytokines.

An estimated 67,440 people in the U.S. will be diagnosed with pancreatic cancer in 2025, according to the latest report from the American Cancer Society. Here are some common symptoms:

Abdominal discomfort in the mid- to- upper abdomen that often radiates to the back

New onset diabetes or worsening blood sugar levels, especially with weight loss

Darkening of urine and lightening of stool

Jaundice (yellowing of the skin and whites of the eyes)

Itching

Nausea and vomiting

Fatigue

Loss of appetite and unintentional weight loss

Kidney grown in the lab. Scientists from Sheba Medical Center and Tel Aviv University have taken human kidney tissue stem cells and grown a 3D organ culture (organoids) to 34 weeks maturity – the longest-lasting and purest ever developed. It will advance research into kidney disease, regenerative medicine and transplants.
https://www.timesofisrael.com/in-a-world-breakthrough-israeli-researchers-grow-first-long-term-human-kidney-in-lab/
Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment. This review not only summarizes the existing evidence on the efficacy of acupuncture in treating VCI, (Vascular Cognitive Impairment) but also synthesizes the current evidence from rs-fMRI studies to elucidate how acupuncture improves cognitive function in VCI patients through central mechanisms.

New Yorker Aug 11 pg 26… Live long and prosper: The seminal paper in Cell had 12 hallmarks of aging, including DNA instability, mitochondrial dysfunction, chronic inflammation, cellular senescence when burned-out cells start oozing toxic sludge, and stem cell exhaustion.  Caloric restriction can shrink muscle mass, lower your libido, and suppress neuronal function.Among the elderly, having difficulty bathing is as grimly determinative of mortality as having heart failure.  Only a quarter of the slowest walkers over 85 survived as long as the fastest walkers. Numerous papers have concluded that genes determine only 7 to 30% of longevity, while your behavior has a much larger vote.

Impact of diet and exercise on mitochondrial quality and mitophagy in Alzheimer’s disease.  a healthy diet and regular exercise play a crucial role in maintaining mitochondrial quality and mitochondrial function, in turn, enhancing mitophagy and synaptic activities that delay AD in the elderly populations.

The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome. The term “Mitochondria nutrients” has been adopted in recent years, and it depicts the adequate nutrients to keep proper mitochondrial function. Different experimental models show that components of the MD, including polyphenols, plant-derived compounds, and polyunsaturated fatty acids, can improve mitochondrial metabolism, biogenesis, and antioxidant capacity.

    High-intensity Interval Training Improves  Mitochondrial Function and Suppresses Thrombin Generation in Platelets undergoing Hypoxic Stress.   We conclude that the high-intensity interval training simultaneously improves mitochondrial bioenergetics and suppresses dynamic mitochondrial functionality and thrombin generation  in platelets undergoing hypoxia.

Endurance exercise rescues progeroid aging and  induces systemic mitochondrial rejuvenation in  mtDNA mutator mice.  The systemic mitochondrial rejuvenation through endurance exercise promises to be an effective therapeutic approach to mitigating mitochondrial dysfunction in aging and related comorbidities.

What’s that spell?
What’s that spell?
What’s that spell?
What’s that spell?
What’s that spell?

yeah, c’mon on all you big strong men
Uncle Sam needs your help again
he’s got himself in a terrible jam
way down yonder in Vietnam
so put down your books and pick up a gun
we’re gonna have a whole lot of fun

and it’s 1, 2, 3, what’re we fighting for?
don’t ask me, I don’t give a damn
next stop is vietnam
and it’s 5, 6, 7, open up the pearly gates
well there ain’t no time to wonder why
whoopee! we’re all gonna die

well c’mon generals, let’s move fast
your big chance has come at last
gotta go out and get those Reds
the only good Commie is one who’s dead
and you know that peace can only be won
when we’ve blown ‘em all to kingdom come

well c’mon on Wall Street
don’t be slow
why this is war a-go-go
there’s plenty good money to be made
by supplin’ the Army with the tools of the trade
just hope and pray that if we drop the bomb
they drop it on-the Vietcong

and it’s 1, 2, 3, what’re we fighting for?
don’t ask me, I don’t give a damn
next stop is vietnam
and it’s 5, 6, 7, open up the pearly gates
well there ain’t no time to wonder why
whoopee! we’re all gonna die

well c’mon mothers throughout this land
pack your boys off to Vietnam
c’mon pops, don’t hesitate
send ‘em off before it’s too late
be the first one on your block to have your boy come home in a box

and it’s 1, 2, 3, what’re we fighting for?
don’t ask me, I don’t give a damn.

There’s a giant doin’ cartwheels, a statue wearin’ high heels
Look at all the happy creatures dancin’ on the lawn
Dinosaur Victrola, listenin’ to Buck Owens
Doot, doot, doo, lookin’ out my back door

Tambourines and elephants are playin’ in the band
Won’t you take a ride on the flyin’ spoon? Doot, doo doo
Wondrous apparition, provided by magician
Doot, doot, doo, lookin’ out my back door
Tambourines and elephants are playin’ in the band
Won’t you take a ride on the flyin’ spoon? Doot, doo doo
Bother me tomorrow, today, I’ll buy no sorrows
Doot, doot, doo, lookin’ out my back door

Forward troubles Illinois, lock the front door, oh boy
Look at all the happy creatures dancin’ on the lawn
Bother me tomorrow, today, I’ll buy no sorrows
Doot, doot, doo, lookin’ out my back door

I was standing by my window
On a cold and cloudy day
When I saw the hearse come rolling
For to carry my mother away.

Will the circle be unbroken
By and by Lord, by and by
There’s a better home awaiting
In the sky Lord, in the sky.

Well, I went back home, home was lonely
For my mother she was gone
And all my family there was cryin’
For out home felt sad and alone.

Will the circle be unbroken
By and by Lord, by and by
There’s a better home awaiting
In the sky Lord, in the sky.

Undertaker, undertaker, undertaker
Won’t you please drive slow
For that lady you are haulin’
Lord, I hate to see her go.

Will the circle be unbroken
By and by Lord, by and by
There’s a better home awaiting
In the sky Lord, in the sky.

There’s a better home awaiting
In the sky Lord, in the sky…

SUMMARY: The extract of red yeast rice (RYR) is the most effective cholesterol-lowering nutraceutical on the market. In particular, its effectiveness is directly related to the amount of monacolin K within the extract (up to 10 mg/day). safe and effective. However, red rice is often mislabelled and misused, in which case it is dangerous.  See below DANGER FOR RED YEAST RICE.

Red Yeast Rice for Hypercholesterolemia – The extract of red yeast rice (RYR) is the most effective cholesterol-lowering nutraceutical on the market. In particular, its effectiveness is directly related to the amount of monacolin K within the extract (up to 10 mg/day). Consuming monacolin K on a daily basis reduces low-density lipoprotein (LDL) cholesterol plasma levels between 15% and 25% within 6 to 8 weeks. The monacolin K found in RYR is a safe and effective supplement for managing mild to moderate hypercholesterolemia in people with no additional cardiovascular risk factors.  The most recent, by Gerard et al., included 20 studies with RYR doses varying between 1,200 mg and 4,800 mg/day and containing from 4.8 mg to 24 mg of monacolin K. The meta-analysis demonstrated that RYR reduced LDL-C by an average of 1.02 mmol/L (39.4 mg/dL) after 2 to 24 months of treatment compared to placebo. This effect on LDL lowering was not different from moderate-intensity statins (0.03 mmol/L) such as pravastatin 40 mg and lovastatin 20 mg. Recent concerns have been voiced regarding the safety of RYR after publication of case reports that claimed toxicity.48 However, according to a recent meta-analysis of 53 RCTs with a total of 8,535 patients (4,437 in the RYR treatment arm and 4,303 in the control arm), use of monacolin K is not associated with an increased risk of muscular adverse events (OR 0.94, 95% CI, 0.53–1.65).49 Furthermore, the study demonstrated a reduced risk of nonmuscular adverse events (OR 0.59, 95% CI, 0.50–0.69) and serious adverse events (OR 0.54, 95% CI, 0.46–0.64) compared to the control group.

DANGER FOR RED YEAST RICE.

SUBtitle: cancer from drinking alcohol prevented by drinking less than 3 glasses daily

Links for new readers:  1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span   3) Recent important nutrition news.  4) A contribution to this newsletter is healthier and less expensive than your multivitamin. Donation link for Nutrition Newsletter .

SHORT NOTES:

1..Consumption of two or more servings per week of yogurt was tied to lower rates of proximal colorectal cancer

2..About 20,000 adults in the United States die from alcohol-associated cancers. Have less than three drinks daily.

3..Adults should get 300 minutes of moderate intensity exercise weekly.

4..US life expectancy vs healthcare costs are among the poorest on earth.

5..The Economist: Intermittent fasting may not help longevity.

6..The gut microbiome drives sugar cravings.

7..Sleep essential for brain waste clearance and healthier aging.

8..Lack of a sense of smell often leads to depression, anxiety and other health issues.

9..Sighing every 5 minutes or so helps prevent the collapse of alveoli in the lungs.

10..Great aging research website. Genomics of Ageing and Rejuvenation Lab.

11..Global average life expectancy has more than doubled from 32 in 1900. The average life expectancy is now 73 years.

LONG NOTES

Using data from studies that have followed participants for decades, researchers found that long-term consumption of two or more servings per week of yogurt was tied to lower rates of proximal colorectal cancer positive for Bifidobacterium, a bacterial species found in yogurt.

The Dietary Guidelines for Americans recommends that adults of legal drinking age (21 years or older) choose not to drink alcohol or to drink alcohol in moderation (2 drinks or fewer in a day for men, 1 drink or fewer in a day for women).  Each year, about 20,000 adults in the United States die from alcohol-associated cancers. It is estimated most of these deaths may have been avoided if all adults had followed the recommended limits on alcohol use in the Dietary Guidelines for Americans instead of drinking above them.  Breast cancer is the most common alcohol-associated cancer among women. Colorectal cancer is the most common alcohol-associated cancer among men.

Adults should get 300 minutes of moderate intensity exercise weekly. Nearly half of our participants in young adulthood had suboptimal levels of physical activity, which was significantly associated with the onset of hypertension. Achieving at least twice the current minimum adult [physical activity] guidelines may be more beneficial for the prevention of hypertension than simply meeting the minimum guidelines,” the researchers wrote in their paper.  And by age 60, between 80 to 90 percent of Black men and women had hypertension, compared with just below 70 percent for White men and around half of White women.

Life expectancy vs healthcare costs are among the poorest on earth.

The Economist: Intermittent fasting may not help longevity.

From Emily Silverman—how are gut microbiome drives sugar cravings; —the influence of sleep on brain waste clearance and aging; —the new findings of microplastics in the brain; —the surprise finding about doctors and A.I.

Targeting autoimmune diseases. (TY Nevet) Israel’s Pepticom (see here previously) is to accelerate the development of its oral IL-17 inhibitor program, targeting improved treatments for autoimmune diseases.

Can you smell the coffee? (TY Israel21c) Researchers at Israel’s Weizmann Institute found that lack of a sense of smell often leads to depression, anxiety and other health issues which link to a reduced lifespan. They also discovered that sighing every 5 minutes or so helps prevent the collapse of alveoli in the lungs.”

GRG Great aging research website of Prof. João Pedro de Magalhães. Genomics of Ageing and Rejuvenation Lab.

Global average life expectancy has more than doubled since 1900. We can expect to live more than twice as long as our friends in 1900. As the chart shows, global average life expectancy was just 32 years at the beginning of the 20th century. This was a short life by today’s standards: in 2023, the average life expectancy had increased to 73 years. That’s 41 years longer.