This is a poster about the book I have written which I hope to publish after October 2025.   Search for Not FDA Allowed to find it.

How few there are that own their own faults, or resoluition enough to mend them!

Links for new readers:  1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span   3) Recent important nutrition news.  4) A financial contribution to this newsletter is less expensive and better for your health than a multivitamin. Please use this new Link to subscribe to newsletter for $52/year.  It will remind you annually to resubscribe. Sorry I am not set up as a non-profit. Donation link to a fund raiser for Nutrition Investigator travel to present research at professional meetings. To be removed from the nutrition list distribution, please email ordman@beloit.edu  SUBJ: remove from list. All writings are to discuss with your physician. Full Disclaimer

SHORT NOTES:

1..I am trying to raise $8,000 to publish my book Not FDA Allowed.

2..Fund raiser for Nutrition Investigator travel to present research at professional meetings.

3..The #1 Exercise for Belly Fat.

4..Fatty 15 improves mitochondrial function 45%, inhibit 18+ proinflammatory cytokines.

5..67,440 people in the U.S. will be diagnosed with pancreatic cancer in 2025.

6..Kidney grown in the lab.

7..Acupuncture in the Treatment of Vascular Cognitive Impairment.

8..The seminal paper in Cell had 12 hallmarks of aging.

9..Caloric restriction can shrink muscle mass, lower your libido, and suppress neuronal function.

10..Among the elderly, having difficulty bathing is as grimly determinative of mortality.

11..Only a quarter of the slowest walkers over 85 survived as long as the fastest walkers.

12..Genes determine only 7 to 30% of longevity.

13..Impact of diet and exercise on mitochondria in Alzheimer’s disease.

14..Mediterranean Diet Improves Mitochondria in Obesity and Metabolic Syndrome.

15..High-intensity Interval Training Improves  Mitochondrial Function.

16.. Endurance exercise rescues progeroid aging and  induces systemic mitochondrial rejuvenation in  mtDNA mutator mice.

LONG NOTES:

Dear Friends of me, Roc,

Please consider supporting my fundraiser by viewing the story here – http://spot.fund/19fgpbfce.  If my average friend gave $10, I would have enough.  For $100, you get the autographed book with my thanks.

I am trying to raise $8,000 to publish my book Not FDA Allowed.  I plan to refund all donations in about 5 months after the book is published and enough copies sell to pay for that $8,000 you helped contribute.  Thanks!

Donation link to a fund raiser for Nutrition Investigator travel to present research at professional meetings, especially the Linus Pauling meeting Sept 9^th.

AARP: The #1 Exercise for cBelly Fat. Lie flat on your back with knees bent, lift your feet and knees to horizontal.

Fatty 15 claims to improve mitochondrial function 45%, inhibit 18+ proinflammatory cytokines.

An estimated 67,440 people in the U.S. will be diagnosed with pancreatic cancer in 2025, according to the latest report from the American Cancer Society. Here are some common symptoms:

Abdominal discomfort in the mid- to- upper abdomen that often radiates to the back

New onset diabetes or worsening blood sugar levels, especially with weight loss

Darkening of urine and lightening of stool

Jaundice (yellowing of the skin and whites of the eyes)

Itching

Nausea and vomiting

Fatigue

Loss of appetite and unintentional weight loss

Kidney grown in the lab. Scientists from Sheba Medical Center and Tel Aviv University have taken human kidney tissue stem cells and grown a 3D organ culture (organoids) to 34 weeks maturity – the longest-lasting and purest ever developed. It will advance research into kidney disease, regenerative medicine and transplants.
https://www.timesofisrael.com/in-a-world-breakthrough-israeli-researchers-grow-first-long-term-human-kidney-in-lab/
Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment. This review not only summarizes the existing evidence on the efficacy of acupuncture in treating VCI, (Vascular Cognitive Impairment) but also synthesizes the current evidence from rs-fMRI studies to elucidate how acupuncture improves cognitive function in VCI patients through central mechanisms.

New Yorker Aug 11 pg 26… Live long and prosper: The seminal paper in Cell had 12 hallmarks of aging, including DNA instability, mitochondrial dysfunction, chronic inflammation, cellular senescence when burned-out cells start oozing toxic sludge, and stem cell exhaustion.  Caloric restriction can shrink muscle mass, lower your libido, and suppress neuronal function.Among the elderly, having difficulty bathing is as grimly determinative of mortality as having heart failure.  Only a quarter of the slowest walkers over 85 survived as long as the fastest walkers. Numerous papers have concluded that genes determine only 7 to 30% of longevity, while your behavior has a much larger vote.

Impact of diet and exercise on mitochondrial quality and mitophagy in Alzheimer’s disease.  a healthy diet and regular exercise play a crucial role in maintaining mitochondrial quality and mitochondrial function, in turn, enhancing mitophagy and synaptic activities that delay AD in the elderly populations.

The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome. The term “Mitochondria nutrients” has been adopted in recent years, and it depicts the adequate nutrients to keep proper mitochondrial function. Different experimental models show that components of the MD, including polyphenols, plant-derived compounds, and polyunsaturated fatty acids, can improve mitochondrial metabolism, biogenesis, and antioxidant capacity.

    High-intensity Interval Training Improves  Mitochondrial Function and Suppresses Thrombin Generation in Platelets undergoing Hypoxic Stress.   We conclude that the high-intensity interval training simultaneously improves mitochondrial bioenergetics and suppresses dynamic mitochondrial functionality and thrombin generation  in platelets undergoing hypoxia.

Endurance exercise rescues progeroid aging and  induces systemic mitochondrial rejuvenation in  mtDNA mutator mice.  The systemic mitochondrial rejuvenation through endurance exercise promises to be an effective therapeutic approach to mitigating mitochondrial dysfunction in aging and related comorbidities.

What’s that spell?
What’s that spell?
What’s that spell?
What’s that spell?
What’s that spell?

yeah, c’mon on all you big strong men
Uncle Sam needs your help again
he’s got himself in a terrible jam
way down yonder in Vietnam
so put down your books and pick up a gun
we’re gonna have a whole lot of fun

and it’s 1, 2, 3, what’re we fighting for?
don’t ask me, I don’t give a damn
next stop is vietnam
and it’s 5, 6, 7, open up the pearly gates
well there ain’t no time to wonder why
whoopee! we’re all gonna die

well c’mon generals, let’s move fast
your big chance has come at last
gotta go out and get those Reds
the only good Commie is one who’s dead
and you know that peace can only be won
when we’ve blown ‘em all to kingdom come

well c’mon on Wall Street
don’t be slow
why this is war a-go-go
there’s plenty good money to be made
by supplin’ the Army with the tools of the trade
just hope and pray that if we drop the bomb
they drop it on-the Vietcong

and it’s 1, 2, 3, what’re we fighting for?
don’t ask me, I don’t give a damn
next stop is vietnam
and it’s 5, 6, 7, open up the pearly gates
well there ain’t no time to wonder why
whoopee! we’re all gonna die

well c’mon mothers throughout this land
pack your boys off to Vietnam
c’mon pops, don’t hesitate
send ‘em off before it’s too late
be the first one on your block to have your boy come home in a box

and it’s 1, 2, 3, what’re we fighting for?
don’t ask me, I don’t give a damn.

There’s a giant doin’ cartwheels, a statue wearin’ high heels
Look at all the happy creatures dancin’ on the lawn
Dinosaur Victrola, listenin’ to Buck Owens
Doot, doot, doo, lookin’ out my back door

Tambourines and elephants are playin’ in the band
Won’t you take a ride on the flyin’ spoon? Doot, doo doo
Wondrous apparition, provided by magician
Doot, doot, doo, lookin’ out my back door
Tambourines and elephants are playin’ in the band
Won’t you take a ride on the flyin’ spoon? Doot, doo doo
Bother me tomorrow, today, I’ll buy no sorrows
Doot, doot, doo, lookin’ out my back door

Forward troubles Illinois, lock the front door, oh boy
Look at all the happy creatures dancin’ on the lawn
Bother me tomorrow, today, I’ll buy no sorrows
Doot, doot, doo, lookin’ out my back door

I was standing by my window
On a cold and cloudy day
When I saw the hearse come rolling
For to carry my mother away.

Will the circle be unbroken
By and by Lord, by and by
There’s a better home awaiting
In the sky Lord, in the sky.

Well, I went back home, home was lonely
For my mother she was gone
And all my family there was cryin’
For out home felt sad and alone.

Will the circle be unbroken
By and by Lord, by and by
There’s a better home awaiting
In the sky Lord, in the sky.

Undertaker, undertaker, undertaker
Won’t you please drive slow
For that lady you are haulin’
Lord, I hate to see her go.

Will the circle be unbroken
By and by Lord, by and by
There’s a better home awaiting
In the sky Lord, in the sky.

There’s a better home awaiting
In the sky Lord, in the sky…

SUMMARY: The extract of red yeast rice (RYR) is the most effective cholesterol-lowering nutraceutical on the market. In particular, its effectiveness is directly related to the amount of monacolin K within the extract (up to 10 mg/day). safe and effective. However, red rice is often mislabelled and misused, in which case it is dangerous.  See below DANGER FOR RED YEAST RICE.

Red Yeast Rice for Hypercholesterolemia – The extract of red yeast rice (RYR) is the most effective cholesterol-lowering nutraceutical on the market. In particular, its effectiveness is directly related to the amount of monacolin K within the extract (up to 10 mg/day). Consuming monacolin K on a daily basis reduces low-density lipoprotein (LDL) cholesterol plasma levels between 15% and 25% within 6 to 8 weeks. The monacolin K found in RYR is a safe and effective supplement for managing mild to moderate hypercholesterolemia in people with no additional cardiovascular risk factors.  The most recent, by Gerard et al., included 20 studies with RYR doses varying between 1,200 mg and 4,800 mg/day and containing from 4.8 mg to 24 mg of monacolin K. The meta-analysis demonstrated that RYR reduced LDL-C by an average of 1.02 mmol/L (39.4 mg/dL) after 2 to 24 months of treatment compared to placebo. This effect on LDL lowering was not different from moderate-intensity statins (0.03 mmol/L) such as pravastatin 40 mg and lovastatin 20 mg. Recent concerns have been voiced regarding the safety of RYR after publication of case reports that claimed toxicity.48 However, according to a recent meta-analysis of 53 RCTs with a total of 8,535 patients (4,437 in the RYR treatment arm and 4,303 in the control arm), use of monacolin K is not associated with an increased risk of muscular adverse events (OR 0.94, 95% CI, 0.53–1.65).49 Furthermore, the study demonstrated a reduced risk of nonmuscular adverse events (OR 0.59, 95% CI, 0.50–0.69) and serious adverse events (OR 0.54, 95% CI, 0.46–0.64) compared to the control group.

DANGER FOR RED YEAST RICE.

SUBtitle: cancer from drinking alcohol prevented by drinking less than 3 glasses daily

Links for new readers:  1) Instructions for new subscribers to use this newsletter and website 2) One Day in Roc’s Life: 46 resolutions to prolong health span   3) Recent important nutrition news.  4) A contribution to this newsletter is healthier and less expensive than your multivitamin. Donation link for Nutrition Newsletter .

SHORT NOTES:

1..Consumption of two or more servings per week of yogurt was tied to lower rates of proximal colorectal cancer

2..About 20,000 adults in the United States die from alcohol-associated cancers. Have less than three drinks daily.

3..Adults should get 300 minutes of moderate intensity exercise weekly.

4..US life expectancy vs healthcare costs are among the poorest on earth.

5..The Economist: Intermittent fasting may not help longevity.

6..The gut microbiome drives sugar cravings.

7..Sleep essential for brain waste clearance and healthier aging.

8..Lack of a sense of smell often leads to depression, anxiety and other health issues.

9..Sighing every 5 minutes or so helps prevent the collapse of alveoli in the lungs.

10..Great aging research website. Genomics of Ageing and Rejuvenation Lab.

11..Global average life expectancy has more than doubled from 32 in 1900. The average life expectancy is now 73 years.

LONG NOTES

Using data from studies that have followed participants for decades, researchers found that long-term consumption of two or more servings per week of yogurt was tied to lower rates of proximal colorectal cancer positive for Bifidobacterium, a bacterial species found in yogurt.

The Dietary Guidelines for Americans recommends that adults of legal drinking age (21 years or older) choose not to drink alcohol or to drink alcohol in moderation (2 drinks or fewer in a day for men, 1 drink or fewer in a day for women).  Each year, about 20,000 adults in the United States die from alcohol-associated cancers. It is estimated most of these deaths may have been avoided if all adults had followed the recommended limits on alcohol use in the Dietary Guidelines for Americans instead of drinking above them.  Breast cancer is the most common alcohol-associated cancer among women. Colorectal cancer is the most common alcohol-associated cancer among men.

Adults should get 300 minutes of moderate intensity exercise weekly. Nearly half of our participants in young adulthood had suboptimal levels of physical activity, which was significantly associated with the onset of hypertension. Achieving at least twice the current minimum adult [physical activity] guidelines may be more beneficial for the prevention of hypertension than simply meeting the minimum guidelines,” the researchers wrote in their paper.  And by age 60, between 80 to 90 percent of Black men and women had hypertension, compared with just below 70 percent for White men and around half of White women.

Life expectancy vs healthcare costs are among the poorest on earth.

The Economist: Intermittent fasting may not help longevity.

From Emily Silverman—how are gut microbiome drives sugar cravings; —the influence of sleep on brain waste clearance and aging; —the new findings of microplastics in the brain; —the surprise finding about doctors and A.I.

Targeting autoimmune diseases. (TY Nevet) Israel’s Pepticom (see here previously) is to accelerate the development of its oral IL-17 inhibitor program, targeting improved treatments for autoimmune diseases.

Can you smell the coffee? (TY Israel21c) Researchers at Israel’s Weizmann Institute found that lack of a sense of smell often leads to depression, anxiety and other health issues which link to a reduced lifespan. They also discovered that sighing every 5 minutes or so helps prevent the collapse of alveoli in the lungs.”

GRG Great aging research website of Prof. João Pedro de Magalhães. Genomics of Ageing and Rejuvenation Lab.

Global average life expectancy has more than doubled since 1900. We can expect to live more than twice as long as our friends in 1900. As the chart shows, global average life expectancy was just 32 years at the beginning of the 20th century. This was a short life by today’s standards: in 2023, the average life expectancy had increased to 73 years. That’s 41 years longer.

What are the worst foods for acid reflux?  Spicy foods, citrus, tomato sauces, and vinegar, which may intensify heartburn. Chocolate, caffeine, onions, peppermint, carbonated drinks, and alcohol, which are all common heartburn triggers.

Foods That Neutralize Stomach Acid

• Yogurt that is not too sour is also excellent for acid reflux, because of the probiotics that help normalize bowel function.
• Ginger. Research has shown that ginger contains compounds, such as gingerol and shogaol, which have anti-inflammatory effects. …
• Gum. Chewing gum in moderation can ease heartburn. …
• High-Fiber Foods. …
• Honey. …
• Lean Protein. …
• Low-Fat and Nonfat Dairy Products. …
• Non-Citrus Fruits. …
• Vegetables.

What settles acid reflux quickly? Taking an antacid can settle acid reflux quickly, typically providing relief from the burning feeling within seconds to minutes. Antacids are available over-the-counter in the form of chewables, dissolving tablets, liquids, and gummies.  I like Pepto-bismol. Pepto-Bismol’s active ingredient, bismuth subsalicylate, neutralizes stomach acid and protects the stomach lining and lower esophagus. It can also help with other gastrointestinal issues, such as heartburn, indigestion, diarrhea, and nausea.  Bismuth also kills Heliobacter pylori, which causes ulcers.

GERD diet: Foods to avoid to reduce acid reflux [Harvard essay]

• Fatty and fried foods, which linger longer in the stomach, making it more likely that stomach acid leaks back up into the esophagus, causing uncomfortable GERD symptoms.
• Spicy foods, citrus, tomato sauces, and vinegar, which may intensify heartburn.
• Chocolate, caffeine, onions, peppermint, carbonated drinks, and alcohol, which are all common heartburn trigge

Besides specific types of foods, changes to eating habits can also help to prevent repeated bouts of heartburn and acid reflux.

• Eat smaller, more frequent meals.
• Do not lie down after eating. This means no naps right after lunch. When you’re standing or sitting, gravity helps keeps acid in the stomach, where it belongs.
• Do not eat during the three to four hours before you go to bed. So, no late suppers or midnight snacks.
• Avoid vigorous exercise for a couple of hours after eating. A strenuous workout can send acid into your esophagus.
• If you’re taking medication to help control your symptoms, it’s probably okay to have a “trigger” food occasionally. But you should generally avoid foods that once caused heartburn.

From a GRG post: I am a chocoholic. I am glad to see large scale studies showing moderate health and life extension benefits. However, the heavy metal content has been a major concern. One person at LongeCity suggested that the heavy metals are tightly bound to the cocoa flavonoids/polyphenols and perhaps that somewhat prevents them (metals) from being absorbed into the body.